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1.发明公开AN OPTICAL ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING (O-OFDM) SYSTEM WITH PULSE-WIDTH MODULATION (PWM) DIMMING 审中-公开OPTISCHES ORTHOGONALES FREQUENZMULTIPLEX（O-OFDM）-SYSTEM MIT PULSWEITENMODULATION（PWM）-DIMMUNG
公开(公告)号：EP3014798A4
公开(公告)日：2017-03-22
申请号：EP14847891
申请日：2014-06-24
申请人： UNIV BOSTON
发明人： ELGALA HANY , LITTLE THOMAS
IPC分类号： H04J11/00 , H04B10/116 , H04J14/00 , H04L25/49 , H04L27/26
CPC分类号： H04B10/116 , H04L25/4902 , H04L27/2627 , H04L27/2697
摘要： An optical orthogonal frequency division multiplexing (O-OFDM) system with pulse-width modulation (PWM) dimming includes a driver responsive to one or more predetermined dimming set points configured to generate PWM signals having a predetermined duty cycle and configured to supply current to one or more light emitting diodes (LEDs). An O-OFDM generator responsive to the one or more predetermined dimming set points and digital data is configured to generate digital inverted O-OFDM signals during on-states of the PWM signals and non-inverted O-OFDM signals during off-states of the PWM signals according to the predetermined duty cycle and convert the digital inverted O-OFDM signals and the digital non-inverted O-OFDM signals to analog output O-OFDM signals. A combiner circuit responsive to the current from the driver and the analog output O-OFDM signals is configured such that the analog output O-OFDM signals modulate the current to the one or more LEDs to provide a high capacity visible light communication link
摘要翻译： 具有脉冲宽度调制（PWM）调光的光学正交频分复用（O-OFDM）系统包括响应于一个或多个预定调光设定点的驱动器，其被配置为产生具有预定占空比的PWM信号，并且被配置为将电流提供给一个 或更多的发光二极管（LED）。 响应于所述一个或多个预定调光设定点和数字数据的O-OFDM发生器被配置为在所述PWM信号和非反相O-OFDM信号的导通状态期间在所述PWM信号和非反相O-OFDM信号的关闭状态期间产生数字反相O-OFDM信号 根据预定占空比的PWM信号，并将数字反相O-OFDM信号和数字非反相O-OFDM信号转换为模拟输出O-OFDM信号。 响应于来自驱动器的电流和模拟输出O-OFDM信号的组合器电路被配置为使得模拟输出O-OFDM信号调制到一个或多个LED的电流以提供高容量可见光通信链路
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公开(公告)号：EP3017039A4
公开(公告)日：2017-03-01
申请号：EP14819499
申请日：2014-07-01
CPC分类号： C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
摘要翻译： 本公开的各个方面和实施方案涉及在体内功能化内源性细菌的方法和组合物。 所述方法包括向内源细菌细胞递送重组噬菌体或被设计成含有至少一个遗传回路的噬菌粒。
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公开(公告)号：EP2909313A4
公开(公告)日：2016-06-15
申请号：EP13829847
申请日：2013-08-15
IPC分类号： C12N5/071
CPC分类号： A61K35/19 , A61K31/404 , A61K31/655 , A61K35/18 , A61K45/06 , A61K2035/124 , C12N5/0641 , C12N5/0644 , C12N5/0647 , C12N2501/60 , C12N2501/999 , C12N2506/03 , C12N2506/45 , G01N33/5044 , G01N2500/10
摘要： This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a stem cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR agonist are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs.
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公开(公告)号：EP2895500A4
公开(公告)日：2016-04-13
申请号：EP13837551
申请日：2013-09-12
申请人： UNIV DUKE , LOS ALAMOS NAT SECURITY LLC , UNIV PENNSYLVANIA , UNIV BOSTON , US GOV HEALTH & HUMAN SERV , UNIV LELAND STANFORD JUNIOR
发明人： HAYNES BARTON F , LIAO HUA-XIN , LYNCH REBECCA M , ZHOU TONGQING , GAO FENG , BOYD SCOTT , SHAW GEORGE M , HAHN BEATRICE H , KEPLER THOMAS B , KORBER BETTE T , KWONG PETER , MASCOLA JOHN
IPC分类号： C07K14/155 , A61K39/12 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
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5.发明公开
公开(公告)号：EP2028936A4
公开(公告)日：2014-02-26
申请号：EP07750529
申请日：2007-02-13
发明人： COTTAREL GUILLAUME , WIERZBOWSKI JAMEY , PAL KOLLOL , KOHANSKI MICHAEL , DWYER DANIEL , COLLINS JAMES , ALMSTETTER MICHAEL , THORMANN MICHAEL , TREML ANDREAS
CPC分类号： A61K45/06 , A61K38/12 , C12Q1/18 , G01N33/5023 , A61K2300/00
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6.发明公开SYSTEM FOR ASSESSING THE EFFICACY OF STORED RED BLOOD CELLS USING MICROVASCULAR NETWORKS 审中-公开系统进行测试RECORDED红细胞使用微血管网络的有效性
公开(公告)号：EP2419862A4
公开(公告)日：2013-10-09
申请号：EP10765101
申请日：2010-04-14
申请人： UNIV BOSTON
IPC分类号： G06K9/00
CPC分类号： B01D63/088 , B01L3/5027 , B01L2200/0647 , B01L2300/0861 , B01L2300/123 , B01L2400/0439 , G01N11/08 , G01N33/80 , Y10S707/99945 , Y10S707/99948
摘要： A system for assessing the microvascular fitness of a sample of stored red blood cells. The system has a network device having at least one network unit. The network unit has a single inlet and a single outlet for the sample and a plurality of microchannels. The plurality of microchannels receive the sample from the single inlet and drain the sample into the single outlet. The network unit includes an aspiration pressure means for providing movement of liquid sample through the at least one network unit. The system further includes an analysis unit that receives the network device therein. The analysis unit includes a sensor for capturing measurements related to the sample and a processor capable of comparing the captured measurements to measurements stored in a database of healthy red blood cells to determine the microvascular fitness of the stored red blood cells.
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7.发明公开
公开(公告)号：EP2410915A4
公开(公告)日：2013-07-03
申请号：EP10756879
申请日：2010-03-25
申请人： UNIV BOSTON
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418 , A61B5/7267 , G06K9/00147 , G06K9/6256 , G06K9/6269 , G06N99/00
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公开(公告)号：EP2507266A4
公开(公告)日：2013-05-29
申请号：EP10835042
申请日：2010-12-01
发明人： GANLEY-LEAL LISA , CONNOR JOHN H
IPC分类号： C07K19/00 , A61K38/17 , A61P37/08 , C07K14/705
CPC分类号： C07K14/7056 , A61K31/56 , A61K38/00 , A61K38/17 , A61K39/0005 , A61K45/06 , C07K14/195 , A61K2300/00
摘要： The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased IgE levels such as e.g., allergy, anaphylaxis, inflammation, lymphoma, and certain cancers.
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9.发明公开PRE-OR POST-EXPOSURE TREATMENT FOR FILOVIRUS OR ARENAVIRUS INFECTION 审中-公开治疗FILOVIRUS-或病毒的侵染之前或ARENA 在中止
公开(公告)号：EP2245154A4
公开(公告)日：2012-12-05
申请号：EP08873458
申请日：2008-12-17
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N2760/10034 , C12N2760/14134 , C12N2760/14171 , C12N2760/14234 , C12N2760/14271 , C12N2760/20243
摘要： The compositions and methods of the invention described herein provide pre- or post-exposure treatments against filovirus or arenavirus infection by expressing one or more genes (e.g., two ore more genes) from filoviruses or arenaviruses in a delivery vehicle (e.g., a recombinant viral vector or a liposome).
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公开(公告)号：EP2061797A4
公开(公告)日：2010-07-28
申请号：EP07814547
申请日：2007-08-29
申请人： UNIV BOSTON , HARVARD COLLEGE
发明人： GILCHREST BARBARA A , ELLER MARK S , KOEHLER ANGELA N , MCPHERSON OLIVIA M , NEUMANN CHRISTOPHER S , LEWIS TIMOTHY A
IPC分类号： C07D498/04 , A61K31/5383 , A61K31/5386
CPC分类号： C07D498/04
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