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153 条记录 (耗时 0.016 秒)

    COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER DISORDERS ASSOCIATED WITH METABOLIC SYNDROME
    3.
    发明公开
    COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER DISORDERS ASSOCIATED WITH METABOLIC SYNDROME 有权
    治疗和预防高脂血症的组合物和方法，脂肪肝，动脉硬化等疾病与代谢综合征

    公开(公告)号：EP2763688A4

    公开(公告)日：2015-04-29

    申请号：EP12838976

    申请日：2012-10-05

    申请人： UNIV VANDERBILT

    发明人： HAWIGER JACK J ,  VEACH RUTH ANN ,  ZIENKIEWICZ JOZEF ,  LIU YAN ,  COLLINS ROBERT D ,  MAJOR AMY

    IPC分类号： A61K38/12 ,  A61K38/00 ,  A61P3/06 ,  A61P3/10

    CPC分类号： A61K38/16 ,  A61K31/397 ,  A61K38/08 ,  A61K38/12 ,  A61K45/06

    摘要： The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.

    摘要翻译： 本发明涉及组合物和方法用于治疗与血脂异常相关的疾病，包括高胆固醇血症，高甘油三酯血症，脂肪性肝炎，动脉粥样硬化，肥胖症，高血糖症，代谢综合征和相关的方面，并与代谢综合征相关的病症。 游离缺失中的组合物和方法盘可用于调节受试者中的脂平衡（脂质稳态）是有用的。 组合物和方法，包括核运输调节剂可给予受调控的转录因子的运输，核进口适配器介导到细胞中胆固醇和甘油三酯水平在血液和肝脏中，减少所得的核 降低动脉粥样硬化病变的大小，体重和高血糖的降低，减少了脂肪肝的炎症，以及肝功能的改善。

    METHODS AND COMPOSITIONS FOR TREATMENT FOR CORONARY AND ARTERIAL ANEURYSMAL SUBARACHNOID HEMORRHAGE
    4.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATMENT FOR CORONARY AND ARTERIAL ANEURYSMAL SUBARACHNOID HEMORRHAGE 审中-公开
    方法和组合物治疗和冠脉动脉瘤性蛛网膜下腔出血

    公开(公告)号：EP2240170A4

    公开(公告)日：2014-10-29

    申请号：EP09708687

    申请日：2009-02-02

    申请人： UNIV VANDERBILT

    发明人： SUMMAR MARSHALL L ,  BARR FREDERICK E ,  THOMPSON REID CARLETON

    IPC分类号： A61K31/198 ,  A61P9/08 ,  A61P9/10

    CPC分类号： A61K31/198

    摘要： Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.

    摘要翻译： 方法和组合物用于治疗与动脉瘤性蛛网膜下腔出血（SAH）相关联的并发症，所述方法包括有效量的一氧化氮前体给药于需要其的受试者。 方法和组合物治疗血管痉挛，所述方法包括有效量的一氧化氮前体给药于需要其的受试者。

    SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS
    7.
    发明公开
    SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS 审中-公开
    取代6-METHYLNIKOTINAMIDE ALS MGLUR5阳性甲状旁腺调节因子

    公开(公告)号：EP2575461A4

    公开(公告)日：2013-12-18

    申请号：EP11787265

    申请日：2011-05-24

    申请人： UNIV VANDERBILT

    发明人： CONN P JEFFREY ,  LINDSLEY CRAIG W ,  STAUFFER SHAUN R ,  ZHOU YA ,  MANKA JASON ,  MACDONALD GREGOR JAMES ,  BARTOLOME-NEBREDA JOSE MANUEL

    IPC分类号： A01N43/40 ,  A61K31/44

    CPC分类号： A61K31/44

    摘要： In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    摘要翻译： 在一个方面，本发明涉及取代的6-甲基烟酰胺类似物，其衍生物和相关化合物，其可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂; 用于制备该化合物的合成方法; 包含该化合物的药物组合物 以及使用所述化合物和组合物治疗与谷氨酸功能障碍有关的神经和精神障碍的方法。 该摘要旨在作为用于在特定领域中进行搜索的目的的扫描工具，并且不旨在限制本发明。