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    CRYSTALLINE 3',5'-CYCLIC DIGUANYLIC ACID
    1.
    发明公开
    CRYSTALLINE 3',5'-CYCLIC DIGUANYLIC ACID 审中-公开
    CRYSTALLINE 3'，5'-CYCLIC DIGUANYLIC ACID

    公开(公告)号：EP3121188A1

    公开(公告)日：2017-01-25

    申请号：EP15759144.7

    申请日：2015-02-27

    申请人： YAMASA CORPORATION

    发明人： TANAKA, Hisaki ,  ISHIGE, Kazuya

    IPC分类号： C07H19/213

    CPC分类号： C07H19/207 ,  C07H1/00 ,  C07H19/213

    摘要： A crystal of free acid of 3',5'-cyclic diguanylic acid containing no metal salt with cobalt, magnesium or the like is provided. A method is sought for obtaining said crystal in a large amount and with ease. By a manufacturing method comprising a step of adding acid to an aqueous solution of 3',5'-cyclic diguanylic acid so as to lower pH to 1 to 3, crystals of 3',5'-cyclic diguanylic acid can be obtained in a large amount with ease. Said crystals are free acid crystals which do not contain a metal salt with cobalt, magnesium or the like.

    摘要翻译： 提供不含金属盐与钴，镁等的3'，5'-环二
    十二烷酸的游离酸结晶。 寻求大量且容易地获得所述晶体的方法。 通过包括向3'，5'-环二甘氨酸的水溶液中加酸以降低pH至1至3的步骤的制造方法，可以得到3'，5'-环二腺苷酸的晶体 大量轻松。 所述晶体是游离酸结晶，其不含与钴，镁等金属盐。

    Method of enzymatically synthesizing 3'-phosphoadenosine-5'-phophosulfate
    3.
    发明公开
    Method of enzymatically synthesizing 3'-phosphoadenosine-5'-phophosulfate 审中-公开
    维生素Zur酶联免疫球蛋白3'-Phosphoadenosin-5'-磷磷酸

    公开(公告)号：EP2100956A1

    公开(公告)日：2009-09-16

    申请号：EP09004307.6

    申请日：2006-01-24

    申请人： YAMASA CORPORATION

    发明人： Ishige, Kazuya ,  Noguchi, Toshitada

    IPC分类号： C12N9/12 ,  C12P19/32

    CPC分类号： C12N9/1229 ,  C12N9/1205 ,  C12N9/1241 ,  C12P19/32

    摘要： A DNA fragment comprising a polynucleotide which is formed of nucleotides 101 to 1,171 in a nucleotide sequence of SEQ ID NO: 9, and which encodes polyphosphate-driven nucleoside 5'-diphosphate kinase (PNDK), wherein a nucleotide sequence corresponding to at least 72 N-terminal amino acid residues is deleted.

    摘要翻译： 一种DNA片段，其包含由SEQ ID NO：9的核苷酸序列中的核苷酸101-1,171形成并且编码多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）的多核苷酸，其中对应于至少72 缺失N-末端氨基酸残基。

    AGENT AGAINST PSYCHOSOCIAL STRESSES
    4.
    发明公开
    AGENT AGAINST PSYCHOSOCIAL STRESSES 审中-公开
    MITTEL GEGEN PSYCHOSOZIALEN STRESS

    公开(公告)号：EP2033647A1

    公开(公告)日：2009-03-11

    申请号：EP07790211.2

    申请日：2007-06-26

    申请人： YAMASA CORPORATION

    发明人： ENDO, Kazuki ,  ASHIDA, Noriyuki

    IPC分类号： A61K31/513 ,  A61K31/7072 ,  A61P25/00 ,  C07D239/54 ,  C07H19/067 ,  C07H21/02

    CPC分类号： C07H21/02 ,  A61K31/513 ,  A61K31/7072 ,  C07D239/54 ,  C07H19/067

    摘要： To provide a novel anti-psychosocial stress agent which is highly safety and can be continuously taken, more particularly, a novel anti-psychosocial stress agent which prevents or alleviates psychosocial stress.
    The invention provides an anti-psychosocial stress agent containing, as an active ingredient, uridylic acid, uridine, or uracil. Since uridylic acid, uridine, or uracil, which is an active ingredient of the anti-psychosocial stress agent of the present invention, is inexpensively available and is a biological component, the agent exhibits high safety and can be continuously taken. Therefore, the anti-psychosocial stress agent of the present invention is effective for mitigating, alleviating, or relieving psychosocial stress, which is an issue in modern society. When the anti-psychosocial stress agent is taken before development of symptoms associated with psychosocial stress, the symptoms can be prevented. The anti-stress effect of the agent is superior to that of GABA, which has become of interest and has been incorporated into, for example, foods.

    摘要翻译： 提供一种高度安全，可持续服用的新型抗心理应激药，更具体地说，是一种防止或缓解心理社会压力的新型抗心理应激药。 本发明提供一种抗心理应激剂，其包含尿苷酸，尿苷或尿嘧啶作为活性成分。 由于作为本发明的抗心理应激药物的有效成分的尿苷酸，尿苷或尿嘧啶是廉价可得的并且是生物成分，所以该试剂表现出高安全性并且可以连续服用。 因此，本发明的抗心理应激药对减轻，减轻或缓解心理社会压力是有效的，这是现代社会的一个问题。 在心理社会压力症状发展前采取抗心理应激药物时，可以预防症状。 该试剂的抗应激作用优于已经成为感兴趣且已被掺入到例如食品中的GABA的抗应激作用。

    METHOD OF STABILIZING PULMONARY SURFACTANT PROTEIN
    6.
    发明公开
    METHOD OF STABILIZING PULMONARY SURFACTANT PROTEIN 有权
    VERFAHREN ZUR STABILISIERUNG EINESOBERFLÄCHENAKTIVENLUNGENPROTEINS

    公开(公告)号：EP1881323A1

    公开(公告)日：2008-01-23

    申请号：EP06746191.3

    申请日：2006-05-10

    申请人： YAMASA CORPORATION

    发明人： TANAKA, Seiji, c/o Yamasa Corporation ,  HAMAOKI, Masaru, c/o Yamasa Corporation

    IPC分类号： G01N33/531 ,  G01N33/53

    CPC分类号： G01N33/6884 ,  C07K14/785 ,  G01N2333/785

    摘要： The present invention relates to a method for long-term stabilizing a pulmonary surfactant protein, to a stabilized aqueous solution containing a pulmonary surfactant protein, and to a kit for assaying a pulmonary surfactant protein which kit contains, as a component reagent, a stabilized aqueous solution containing a pulmonary surfactant protein.
    The invention provides a method for stabilizing a pulmonary surfactant protein, the method including causing the pulmonary surfactant protein to be present with a calcium ion and an oxidizing/reducing substance.
    The invention also provides an aqueous solution containing a pulmonary surfactant protein which has been stabilized by use of a calcium ion and an oxidizing/reducing substance in combination.
    The invention also provides a kit for assaying a pulmonary surfactant protein present in a sample through an immunological technique employing antigen-antibody reaction, the kit containing, as a standard solution of pulmonary surfactant protein, an aqueous solution containing a pulmonary surfactant protein which has been stabilized by use of a calcium ion and an oxidizing/reducing substance in combination.

    摘要翻译： 本发明涉及一种用于长期稳定肺表面活性蛋白的方法，含有肺表面活性蛋白的稳定化水溶液，以及用于测定肺表面活性蛋白的试剂盒，该试剂盒含有作为组分试剂的稳定水溶液 含有肺表面活性蛋白的溶液。 本发明提供了一种稳定肺表面活性蛋白的方法，该方法包括使肺表面活性蛋白与钙离子和氧化还原物质一起存在。 本发明还提供含有通过使用钙离子和氧化还原物质组合而稳定的肺表面活性蛋白质的水溶液。 本发明还提供了一种用于通过使用抗原 - 抗体反应的免疫技术测定样品中存在的肺表面活性蛋白的试剂盒，该试剂盒含有作为肺表面活性蛋白的标准溶液的含有肺表面活性蛋白的水溶液 通过组合使用钙离子和氧化还原物质来稳定。

    METHOD OF ENZYMATICALLY SYNTHESIZING 3'-PHOSPHOADENOSINE-5'-PHOSPHOSULFATE
    7.
    发明公开
    METHOD OF ENZYMATICALLY SYNTHESIZING 3'-PHOSPHOADENOSINE-5'-PHOSPHOSULFATE 审中-公开
    VERFAHREN ZUR ENZYMATISCHEN SYNTHESE EINES 3'-磷脂酰-5'-磷脂

    公开(公告)号：EP1842910A1

    公开(公告)日：2007-10-10

    申请号：EP06712278.8

    申请日：2006-01-24

    申请人： YAMASA CORPORATION

    发明人： ISHIGE, Kazuya, c/o Yamasa Corporation ,  NOGUCHI, Toshitada, c/o Yamasa Corporation

    IPC分类号： C12N15/00 ,  C12N9/12 ,  C12N15/09

    CPC分类号： C12N9/1229 ,  C12N9/1205 ,  C12N9/1241 ,  C12P19/32

    摘要： The invention provides a method for producing 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5'-triphosphate sulfurylase (ATPS) and adenosine 5'-phosphosulfate kinase (APSK), wherein an adenosine 5'-triphosphate (ATP) supply/regeneration system including adenosine 5'-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5'-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5'-triphosphate (ATP) supply/regeneration system including adenosine 5'-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5'-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP.

    摘要翻译： 本发明提供了制备3'-磷酸腺苷5'-磷酸硫酸（PAPS）的方法，该方法包括使用腺苷5'-三磷酸硫酸化酶（ATPS）和腺苷5'-磷酸硫酸激酶（APSK）对ATP进行硫酸化和磷酸化， 其中包括腺苷5'-单磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和多磷酸盐：AMP磷酸转移酶（PAP）的腺苷5'-三磷酸（ATP）供应/再生系统，或 使用包括腺苷5'-磷酸（AMP），多磷酸盐，多磷酸盐驱动的核苷5'-二磷酸激酶（PNDK）和腺苷酸激酶（ADK）的腺苷5'-三磷酸（ATP）供应/再生系统代替ATP。

    4'-C-Substituted-2-Haloadenosine derivative
    9.
    发明公开
    4'-C-Substituted-2-Haloadenosine derivative 有权
    4'-C-取代物2-卤代腺嘌呤

    公开(公告)号：EP1589026A1

    公开(公告)日：2005-10-26

    申请号：EP05006326.2

    申请日：2005-03-23

    申请人： YAMASA CORPORATION

    发明人： Kohgo, Satoru ,  Ohrui, Hiroshi ,  Kodama, Eiichi c/o Institute for Virus Research ,  Matsuoka, Masao ,  Mitsuya, Hiroaki

    IPC分类号： C07H19/16 ,  C07H19/173 ,  C07H19/20 ,  A61K31/7076 ,  A61P31/18

    CPC分类号： C07H19/16

    摘要： The present invention provides a 4'-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]:
    (wherein X represents a halogen atom, R 1 represents an ethynyl group or a cyano group, and R 2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor.

    摘要翻译： 本发明提供由下式表示的4'-C-取代-2-卤代腺苷衍生物：ÄIÜ，ÄIIÜ或ÄIIIÜ：（其中X表示卤素原子，R 1表示乙炔基或氰基 基团，R 2表示氢，磷酸酯残基或磷酸酯衍生物残基）。 本发明还提供含有该衍生物和其药学上可接受的载体的药物组合物。

    PROCESS FOR PRODUCING 2 -DEOXYGUANOSINE
    10.
    发明公开
    PROCESS FOR PRODUCING 2 -DEOXYGUANOSINE 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON 2-DESOXYGUANOSIN

    公开(公告)号：EP1457568A1

    公开(公告)日：2004-09-15

    申请号：EP02786164.0

    申请日：2002-12-20

    申请人： YAMASA CORPORATION

    发明人： NOGUCHI, Toshitada ,  HAMAMOTO, Tomoki ,  OKUYAMA, Kiyoshi ,  SHIBUYA, Susumu

    IPC分类号： C12P19/40

    CPC分类号： C12P19/40

    摘要： The invention provides a process for producing 2'-deoxyguanosine, characterized in that the process includes reacting one compound selected from the group consisting of guanosine, guanosine 5'-monophosphate, and 2-amino-6-substituted purine with 2'-deoxynucleoside in the presence of nucleoside deoxyribosyl transferase and a hydrolase.
    According to the process of the present invention, 2'-deoxyguanosine can be synthesized efficiently from inexpensive and easily available starting materials. Since no guanosine, which disturbs purification, is virtually present in a reaction mixture, isolation and purification of 2'-deoxyguanosine can be performed in a very simple manner. Thus, the process for producing 2'-deoxyguanosine is practical.

    摘要翻译： 本发明提供了一种生产2'-脱氧鸟苷的方法，其特征在于该方法包括使选自鸟苷，鸟苷5'-单磷酸和2-氨基-6-取代嘌呤的一种化合物与2'-脱氧核苷在 核苷脱氧核糖基转移酶和水解酶的存在。 根据本发明的方法，可以从廉价且易于获得的起始原料中有效地合成2'-脱氧鸟苷。 由于没有干扰纯化的鸟苷实际上存在于反应混合物中，所以可以以非常简单的方式进行2'-脱氧鸟苷的分离和纯化。 因此，生产2'-脱氧鸟苷的方法是实用的。