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1.发明授权BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF 有权双环取代吡唑酮衍生物AZO，PROCESS FOR THEIR和医药用途
公开(公告)号：EP2236500B1
公开(公告)日：2014-12-24
申请号：EP09703490.4
申请日：2009-01-04
发明人： TANG, Peng Cho , LÜ, Hejun , ZHENG, Hao , CHEN, Yiqian , FEI, Hongbo , WANG, Shenglan , WANG, Li
IPC分类号： C07D231/22 , C07D231/38 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/4152 , A61K31/4155 , A61K31/427 , A61P7/00
CPC分类号： C07D417/12 , C07D231/08 , C07D231/22 , C07D231/38 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/12
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2.发明公开BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF 有权双环取代吡唑酮衍生物AZO，PROCESS FOR THEIR和医药用途
公开(公告)号：EP2236500A1
公开(公告)日：2010-10-06
申请号：EP09703490.4
申请日：2009-01-04
发明人： TANG, Peng Cho , LÜ, Hejun , ZHENG, Hao , CHEN, Yiqian , FEI, Hongbo , WANG, Shenglan , WANG, Li
IPC分类号： C07D231/20 , C07D307/79 , C07D311/04 , A61K31/4152 , A61K31/343 , A61K31/352 , A61K31/655 , A61P7/00
CPC分类号： C07D417/12 , C07D231/08 , C07D231/22 , C07D231/38 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/12
摘要： The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.
摘要翻译： 所述双环substituiertem式（I）或药物上可接受的盐，水合物的吡唑啉酮偶氮衍生物或溶剂化物，它们的制备方法，药物组合物包含相同和它们作为治疗剂使用，爱特别是作为血小板生成素（TPO）模拟物和它们的 使用作为血小板生成素受体的激动剂是游离缺失盘。 在式（I）的取代基的定义如在说明书中所定义的相同。
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3.发明公开DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF 有权DIHYDROPTERIDINONDERIVATE，HERSTELLUNGSVERFAHRENDAFÜRUND PHARMAZEUTISCHE ANWENDUNG DAVON
公开(公告)号：EP2481739A1
公开(公告)日：2012-08-01
申请号：EP10818228.8
申请日：2010-09-14
发明人： TANG, Peng Cho , ZHANG, Nong , ZHANG, Baolei , WANG, Weimin , ZHENG, Hao , WU, Lin
IPC分类号： C07D475/00 , C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61P35/00 , A61P31/00 , A61P29/00 , A61P37/00
CPC分类号： C07D475/00 , C07D519/00
摘要： Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.
摘要翻译： 公开了二氢哌啶酮衍生物，其制备方法和药物用途。 特别地，由通式（I）表示的新的二氢哌啶酮衍生物，其中通式（I）的每个取代基如说明书中所定义，其制备方法，包含所述衍生物的药物组合物及其作为治疗剂的用途，特别是作为Plk激酶 公开了抑制剂。
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