公开(公告)号：EP1502602A2

公开(公告)日：2005-02-02

申请号：EP04076709.7

申请日：1999-10-05

申请人： Pharmexa A/S

发明人： Steinaa, Lucilla ,  Mouritsen, Soren ,  Nielsen, Klaus Gregorius ,  Haaning, Jesper ,  Leach, Dana ,  Dalum, Iben ,  Gautam, Anand ,  Rasmussen, Peter Birk ,  Karlsson, Gunilla

IPC分类号： A61K39/39 ,  A61K38/17 ,  A61K38/18 ,  C07K14/50 ,  C07K14/705 ,  C07K14/71 ,  C12N15/63 ,  C12N5/16 ,  C12N15/12

CPC分类号： C07K16/3069 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/6081 ,  C07K2317/34 ,  Y02A50/412

摘要： A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells aer disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.

摘要翻译： 公开了诱导针对细胞抗原的细胞介导的免疫的方法。 更具体地，本发明提供了针对弱抗原，特别是自身蛋白诱导细胞毒性T淋巴细胞免疫的方法。 该方法要求诱导抗原呈递细胞呈现弱抗原的至少一个CTL表位，同时呈现至少一种外源性T辅助淋巴细胞表位。 在优选的实施方案中，抗原是癌特异性抗原，例如， PSM，Her2或FGF8b。 该方法可以通过使用传统的多肽疫苗接种，也可以通过使用活减毒疫苗或核酸接种来进行。 本发明还提供PSM，Her2和FGF8b的免疫原性类似物以及编码这些类似物的核酸分子。 还公开了载体和转化细胞。 本发明还提供了用于鉴定弱或非免疫原性抗原的免疫原性类似物的方法。

公开(公告)号：EP1259251A2

公开(公告)日：2002-11-27

申请号：EP01905632.4

申请日：2001-02-19

申请人： Pharmexa A/S

发明人： BIRK, PeterPharmexa A/S ,  JENSEN, Martin, RolandPharmexa A/S ,  NIELSEN, Klaus, GregoriusPharmexa A/S

IPC分类号： A61K38/17 ,  A61K39/00 ,  C07K14/435 ,  C07K19/00

CPC分类号： G01N33/6896 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/19 ,  A61K39/00 ,  A61K39/0007 ,  A61K39/385 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  C07K14/4711 ,  C07K2319/00 ,  G01N2333/4709 ,  G01N2500/04 ,  Y02A50/412 ,  A61K2300/00

摘要： Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloidogenic proteins (proteins contributing to formation of amyloid) such as beta amyloid (A²). Immunization is preferably effected by administration of analogues of autologous amyloidogenic polypeptides, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A² which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the majority of A²'s B-cell epitopes. Also disclosed are nucleic acid vaccination against amyloidogenic polypeptides and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic analogues of the amyloidogenic proteins, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

公开(公告)号：EP2358388A1

公开(公告)日：2011-08-24

申请号：EP09784029.2

申请日：2009-10-15

申请人： ALK-Abelló A/S

发明人： JACOBI, Henrik Hugo ,  WÜSTENBERG, Eike Gunther ,  MÆRKEDAHL, Lise Lund

IPC分类号： A61K39/35 ,  A61K39/39 ,  A61P37/08

CPC分类号： A61K39/35 ,  A61K39/39

摘要： This invention relates to the use of a pharmaceutical product comprising allergen and optionally an adjuvant for fast up-dosing in connection with allergy vaccination wherein a reduced number of injections are used. The invention also relates to the pharmaceutical product as such.

公开(公告)号：EP1320377B1

公开(公告)日：2011-03-23

申请号：EP00961444.7

申请日：2000-09-01

申请人： Epimmune Inc.

发明人： SETTE, Alessandro ,  SIDNEY, John ,  SOUTHWOOD, Scott

IPC分类号： C07K7/04 ,  A61K38/00

CPC分类号： C07K14/005 ,  C07K14/445 ,  C07K14/4746 ,  C07K14/4748 ,  C07K14/71 ,  C12N2730/10122 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2770/24222 ,  Y02A50/412

摘要： The present invention provides peptide compositions capable of binding glycoproteins encoded by HLA, HLA-B, and HLA-C alleles and inducing T cell activation in T cells restricted by the HLA allele. The peptides are useful to elicit an immune response against a desired antigen.

公开(公告)号：EP1805969A1

公开(公告)日：2007-07-11

申请号：EP05796435.5

申请日：2005-10-21

申请人： Inflow ApS

发明人： MØRCK, Christian ,  HALVER, Lars ,  KRAP, Svenne

IPC分类号： H04L29/08

CPC分类号： G06F17/30873 ,  G06F2216/07 ,  H04L29/08

摘要： A method and a computer network for two computers to communicate, where one computer generates an instruction set for the second computer to carry out, the instruction set including an instruction for reloading the instruction set, and at least one instruction set comprising an instruction for the second computer to request further data from the first computer, a third computer, or a website

公开(公告)号：EP1328297B1

公开(公告)日：2009-09-30

申请号：EP01978210.1

申请日：2001-10-12

申请人： Cytoguide ApS

发明人： MOESTRUP, Soren ,  MOLLER, Holger, J.

IPC分类号： A61K47/48 ,  G01N33/566 ,  C07K19/00 ,  C07K14/805 ,  C07K14/47 ,  C07K14/705

CPC分类号： G01N33/721 ,  A61K38/00 ,  A61K47/6445 ,  C07K14/70596 ,  C07K14/805 ,  Y02A50/411 ,  Y02A50/58

摘要： The present invention relates to haptoglobin-haemoglobin (Hp-Hb) complex or a part thereof or a mimic thereof being operably linked to a substance and capable of binding a CD163 receptor. Furthermore, the invention relates to a CD163 variant, membrane bound or soluble, capable of binding at least one haptoglobin-haemoglobin (Hp-Hb) complex, and the use of the Hp-Hb complex and the CD163 receptor for therapy.

公开(公告)号：EP1173573A1

公开(公告)日：2002-01-23

申请号：EP00920423.1

申请日：2000-04-19

申请人： Pharmexa A/S

发明人： KLYSNER, Steen

IPC分类号： C12N15/24 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K31/70 ,  A61K48/00 ,  C07K14/54 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  C12N15/70 ,  C12N15/86 ,  G01N33/68 ,  A61P37/00

CPC分类号： C07K14/5409 ,  A61K39/00 ,  A61K39/0005 ,  A61K2039/51 ,  A61K2039/53 ,  C07K2319/55

摘要： The present invention relates to improvements in therapy and prevention of conditions characterized by an elevated level of eosinophil leukocytes, i.e. conditions such as asthma and other chronic allergic diseases. A method is provided for down-regulating interleukin 5 (IL5) by enabling the production of antibodies against IL5 thereby reducing the level of activity of eosinophils. The invention also provides for methods of producing modified IL5 useful in this method as well as for the modified IL5 as such. Also encompassed by the present invention are nucleic acid fragments encoding modified IL5 as well as vectors incorporating these nucleic acid fragments and host cells and cell lines transformed therewith. The invention also provides for a method for the identification of IL5 analogues which are useful in the method of the invention as well as for compositions comprising modified IL5 or comprising nucleic acids encoding the IL5 analogues. The preferred embodiment of the present invention entails the use of variants of IL5, where foreign T helper epitopes are introduced so as to induce production of cross-reactive antibodies capable of binding to autologous IL5.

摘要翻译： 本发明涉及改善治疗和预防以嗜酸性粒细胞白细胞水平升高为特征的病症，即诸如哮喘和其它慢性过敏性疾病的病症。 提供了一种通过使IL5产生抗体来降低白细胞介素5（IL5）的下调方法，从而降低嗜酸性粒细胞的活性水平。 本发明还提供了用于该方法以及修饰的IL5本身的生产修饰的IL5的方法。 本发明还包括编码修饰的IL5的核酸片段以及掺入这些核酸片段和宿主细胞的载体以及由其转化的细胞系。 本发明还提供了用于鉴定IL5类似物的方法，其可用于本发明的方法以及包含修饰的IL5或包含编码IL5类似物的核酸的组合物。 本发明的优选实施方案需要使用IL5的变体，其中引入外源T辅助表位，以便诱导能够结合自体IL5的交叉反应性抗体的产生。

公开(公告)号：EP1114166A1

公开(公告)日：2001-07-11

申请号：EP99942778.4

申请日：1999-09-13

申请人： M & E Biotech A/S

发明人： HALKIER, Torben ,  HAANING, Jesper

IPC分类号： C12N15/62 ,  C12N15/86 ,  C12N15/12 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C07K14/705 ,  A61K39/00 ,  A61K31/713 ,  G01N33/50

CPC分类号： C07K14/70575 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/02 ,  C12N2799/021 ,  Y02A50/412

摘要： The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment/amelioration of diseases characterized by excessive loss of bone mass, e.g. osteoporosis. Down-regulation is effected by inducing an immune response against OPGL in an individual in need thereof. Immune responses can be raised by classical immunization with immunogenic variants of OPGL or by nucleic acid immunization where the nucleic acids encode the OPGL variant. The invention also pertains to compositions, polypeptides and nucleic acids useful in the invention, as well as to vectors and transformed host cells useful in the preparation thereof.

公开(公告)号：EP1335938B1

公开(公告)日：2010-09-22

申请号：EP01982197.4

申请日：2001-11-09

申请人： F. Hoffmann-La Roche Ltd.

发明人： GRAVERSEN, Jonas ,  MOESTRUP, S ren

IPC分类号： C07K14/775 ,  C07K19/00 ,  A61K38/17

CPC分类号： C07K14/775 ,  A61K38/47 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/73 ,  C12N15/62

摘要： The invention relates to an apolipoprotein construct, an apolipoprotein construct for use as a medicament, a nucleic acid sequence encoding the apolipoprotein construct, a vector comprising the nucleic acid sequence, a method for producing the apolipoprotein construct, and use of the apolipoprotein construct for the preparation of apharmaceutical composition. The presented data document that the constructs according to the invention are capable of binding lipids, are capable of binding cubilin, which is a strong Apo Al receptor, stronger than native Apo A-I and that the plasma half life of the constructs is at least tripled compared to native Apo A-I. Together these data document that the constructs according to the invention are strong candidates for treatment of cardiovascular diseases.

公开(公告)号：EP0986753B2

公开(公告)日：2005-08-10

申请号：EP98913541.3

申请日：1998-04-07

申请人： BioImage A/S

发明人： Thastrup, Ole ,  Bjorn, Sara Petersen ,  Tullin, Soren ,  Kasper, Almholt ,  Scudder, Kurt ,  Terry, Bernard Robert ,  Arkhammar, Per Olof Gunnar

IPC分类号： G01N33/53

CPC分类号： G01N33/5041 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5035 ,  G01N33/533 ,  G01N33/582 ,  G01N2333/43595 ,  G01N2333/9121