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公开(公告)号：EP0820512A1
公开(公告)日：1998-01-28
申请号：EP96912728.0
申请日：1996-04-12
发明人： BANDMAN, Olga , COLEMAN, Roger , STUART, Susan, G. , BRAXTON, Scott, Michael , RHODES, Eric, T. , COCKS, Benjamin, Graem
CPC分类号： C07K14/523 , A61K38/00
摘要： The present invention relates to novel nucleotide and amino acid sequences for a novel C-C chemokine initially found in a cDNA library from blood cells of an individual having Hypereosinophilic Syndrome. The present invention also provides for antisense molecules to the nucleotide sequences which encode EEC, expression vectors for the production of purified EEC, antibodies capable of binding specifically to EEC, hybridization probes or oligonucleotides for the detection of EEC-encoding nucleotide sequences EEC, diagnostic tests for chemokine activation based on EEC-encoding nucleic acid molecules and antibodies capable of binding specifically to EEC.
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公开(公告)号：EP0646017A1
公开(公告)日：1995-04-05
申请号：EP91909691.0
申请日：1991-04-26
发明人： BECK, Lee, R. , STOLLE, Ralph, J.
摘要： An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and/or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are non reactive in animals and humans as allergens. Said factor(s), however, are highly effective in preventing or alleviating allergic reactions.
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公开(公告)号：EP0569578A1
公开(公告)日：1993-11-18
申请号：EP92925273.0
申请日：1992-11-16
申请人： AMOCO CORPORATION
发明人： MCKENZIE, R., Scott
IPC分类号： C12Q1
CPC分类号： C12Q1/6832 , Y02A50/451
摘要： A method for enhancing the hybridization signal of a nucleic acid hybridization assay for the DNA or RNA of a Salmonella in a sample by adding the sample to a RV growth medium under conditions sufficient to allow any Salmonella in the sample to propagate, propagating Salmonella, if any, in the medium for a time sufficient to allow the number of Salmonella to reach a predetermined titer, removing trace minerals from the medium, adding a nucleic acid probe to the medium under stringency conditions sufficient to allow the probe to preferentially hybridize with the Salmonella, if any, to form hybridization products that emit an enhanced signal, and assaying the medium to detect the enhanced signal. The method is especially suited for detecting Salmonella in food samples.
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4.发明公开
公开(公告)号：EP0568530A1
公开(公告)日：1993-11-10
申请号：EP91909551.0
申请日：1991-05-17
IPC分类号： A23L1
摘要： L'invention se rapporte à un produit alimentaire préparé par fermentation et pratiquement à base de son de céréales, contenant des micro-organismes vivants et présentant des qualités nutritionnelles utiles à la santé ainsi qu'un goût agréable. L'invention se rapporte également à un procédé de fabrication de produits alimentaires riches en fibres, faciles à utiliser et au goût agréable. D'après le procédé, on peut préparer des produits alimentaires non périssables, présentant un contenu élevé en fibres diététiques, un goût agréable et des qualités nutritionnelles, par fermentation régulée au moyen de micro-organismes pourvus de propriétés utiles par rapport à la technologie, la santé ou le produit. De plus, on améliore les possibilités de fonctionnement des micro-organismes sains et bénéfiques utilisés, étant donné que les composants de la fibre diététique protègent le micro-organisme quand ils passent dans le système digestif.
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公开(公告)号：EP0561960A1
公开(公告)日：1993-09-29
申请号：EP92901653.0
申请日：1991-12-05
申请人： IMMUNEX CORPORATION
CPC分类号： C07K16/2869 , A61K38/00 , C07K14/705 , C07K14/715
摘要： Sont décrits des protéines réceptrices du facteur inhibiteur de la leucémie (LIF-R), des ADN et des vecteurs d'expression encodant LIF-R, ainsi que des procédés pour produire LIF-R sous forme de produits de culture cellulaire de recombinaison.
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6.发明公开CLONING AND EXPRESSING VARIOUS RESTRICTION ENDONUCLEASES AND MODIFICATION METHYLASES FROM $i(NEISSERIA) 失效克隆和各类RESTRICTED核酸内切酶和-I（奈瑟）的甲基化酶的修改文稿。
公开(公告)号：EP0532655A1
公开(公告)日：1993-03-24
申请号：EP91911666.0
申请日：1991-06-07
CPC分类号： C12N9/1007 , C12N9/22 , Y10S435/871
摘要： Hôtes recombinés contenant et exprimant divers gènes d'endonucléase de restriction de type II et/ou de méthylase de modification. L'invention concerne notamment les endonucléases de restriction clonées, NgoAIII et NgoAI, qui reconnaissent et clivent dans ou à proximité de la séquence d'ADN bicaténaire, 5' CCGCGG 3' et 5' PuGCGCPy 3', respectivement. L'invention concerne également des gènes de méthylase de modification clonés correspondant auxdites endonucléases de restriction. De plus, l'invention concerne une méthylase de modification clonée, M.NgoAII. Une source de ces enzymes est constituée par Neisseria gonorrhoeae, bien qu'on puisse utiliser d'autres microorganismes afin d'isoler les isoschizomères d'endonucléases de restriction et les isoschizomères de méthylases de modification de l'invention.
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7.发明公开SOLVENT VEHICLES FOR REAGENT DELIVERY IN OLIGONUCLEOTIDE SYNTHESIS USING AUTOMATED PULSE JETTING DEVICES 失效注射用反应堆溶剂车辆寡核苷酸与自动脉冲注射装置合成
公开(公告)号：EP0946582A1
公开(公告)日：1999-10-06
申请号：EP97951738.0
申请日：1997-12-12
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： Solvent vehicles and methods of their use in the pulse jet delivery of reagents in automated oligonucleotide synthesis by the solid-phase phosphoramidite method are provided. For pulse jet delivery of the activated monomer, acetonitrile in combination with at least one stabilizer co-solvent is employed as the solvent vehicle, where the stabilizer co-solvent is an inert, organic solvent having a boiling point of at least 100 °C. For pulse jet delivery of the detritylation reagent, a mono- or disubstituted methane is employed as the solvent vehicle, where substituents have a molecular weight greater than 36 daltons. Use of the solvent vehicles according to the subject invention provides for reduced reagent precipitation in the pulse jet tubes and improved results.
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公开(公告)号：EP0840788A1
公开(公告)日：1998-05-13
申请号：EP96921564.0
申请日：1996-06-04
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel serpin (CAPE) expressed in human hypothalamus. The present invention also provides for antisense molecules to the nucleotide sequences which encode CAPE, expression vectors for the production of purified CAPE, antibodies capable for binding specifically to CAPE, hybridization probes or oligonucleotides for the detection of CAPE-encoding nucleotide sequences, genetically engineered host cells for the expression of CAPE, a pharmaceutical composition containing biologically active CAPE, a diagnostic test based on CAPE-encoding nucleic acid molecules, and treatment methods comprising administration of biologically active CAPE.
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公开(公告)号：EP0832282A1
公开(公告)日：1998-04-01
申请号：EP96917035.0
申请日：1996-06-03
发明人： GUEGLER, Karl, J.
CPC分类号： C12N15/1096 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N9/6472 , C12Q1/686 , C12Q2531/131
摘要： A method for obtaining longer cDNA sequences is provided. The method utilizes a known genomic DNA sequence or a partial cDNA sequence, such as can be obtained from GenBank partial cDNAs. Two PCR primers are designed to correspond to the ends of the known partial sequence and to anneal to DNA in a cDNA library so as to initiate extension away from the known cDNA and the other primer. The primers are added to a cDNA library with appropriate enzymes and extend through additional DNA sequence to produce PCR products, which are subsequently purified and sequenced to provide new sequences. The new sequences are then compared with the known partial cDNA sequence for areas of overlap, and the sequence is extended beyond the overlapping areas to provide longer DNA sequence.
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公开(公告)号：EP0781336A1
公开(公告)日：1997-07-02
申请号：EP96923586.0
申请日：1996-06-28
IPC分类号： G01N33 , A61K31 , A61K38 , A61K39 , A61K48 , A61P29 , C07K14 , C07K16 , C12N5 , C12N9 , C12N15 , C12P21
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
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