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    Serum protein profiling for the diagnosis of epithelial cancers
    2.
    发明公开
    Serum protein profiling for the diagnosis of epithelial cancers 审中-公开
    血清蛋白分析fürdie诊断von Epithelkrebs

    公开(公告)号：EP1477803A1

    公开(公告)日：2004-11-17

    申请号：EP03090153.2

    申请日：2003-05-23

    申请人： Europroteome AG

    发明人： Ebert, Matthias ,  Wiemar, Jan ,  Meuer, Jörn

    IPC分类号： G01N33/48 ,  G01N33/50

    CPC分类号： G01N33/57488 ,  G01N30/8655 ,  G01N33/48 ,  G01N33/50 ,  G01N2030/8813 ,  G01N2030/8831

    摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion, subjects having an epithelial cancer or a metastasised epithelial cancer or subjects having an acute and chronic inflammation of the epithelium. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium.

    摘要翻译： 本发明提供生物分子和这些生物分子用于上皮癌的鉴别诊断或上皮的急性和慢性炎症的用途。 特别地，本发明提供了用于检测测试样品内的生物分子的方法以及包含对于健康受试者，具有癌前病变的受试者，具有上皮癌或转移性上皮癌的受试者或具有转移上皮癌的受试者的生物分子的质量分布的数据库 急性和慢性炎症的上皮细胞。 此外，本发明提供了使用气相离子光谱法表征所述生物分子的方法。 此外，本发明提供鉴定所述生物分子的方法，只要它们是蛋白质或多肽即可。 本发明还提供了用于上皮癌鉴别诊断或上皮的急性和慢性炎症的试剂盒。

    Geotextile mat based soilless sod
    3.
    发明公开
    Geotextile mat based soilless sod 审中-公开
    地毯涂层磨砂Rasenbahnkultur

    公开(公告)号：EP1421839A1

    公开(公告)日：2004-05-26

    申请号：EP02090387.8

    申请日：2002-11-20

    申请人： Elmaliach, Daniel

    发明人： Elmaliach, Daniel

    IPC分类号： A01C1/04 ,  A01G1/00

    CPC分类号： A01C1/044 ,  A01G20/10 ,  A01G24/00 ,  Y02P60/216

    摘要： A soilless sod and a method of producing same are disclosed. The method comprises providing a growth mat with cotton and viscose fibers, providing grass seeds or grass sprigs to the growth mat, providing grass sprigs onto the growth mat, and providing a cover mat on top of the upper side of the growth mat. The soilless sod comprises a geo-textile mat being a growth mat, growing material consisting of any combination of grass seeds and grass sprigs, and a cover mat that is in touch with the upper side of the growth mat. The cover mat may be affixed to the growth mat by any of stitch bonding or punch needling or sewing or bonding.

    摘要翻译： 公开了一种无土棉纱及其制造方法。 该方法包括提供一种具有棉和粘胶纤维的生长垫，向生长垫提供草种子或草小枝，在生长垫上提供草丛，并在生长垫的上侧顶部提供覆盖垫。 无土豆包括作为生长垫的地毯织物垫，由草种子和草小枝的任何组合组成的生长材料，以及与生长垫的上侧接触的覆盖垫。 覆盖垫可以通过任何针迹结合或冲孔针刺或缝合或粘合固定到生长垫上。

    METHOD AND DEVICE FOR DIRECTED SORT COMBINATIONAL SYNTHESIS
    4.
    发明公开
    METHOD AND DEVICE FOR DIRECTED SORT COMBINATIONAL SYNTHESIS 审中-公开
    方法和设备组合合成的前瞻性分拣

    公开(公告)号：EP1417482A2

    公开(公告)日：2004-05-12

    申请号：EP02763336.1

    申请日：2002-07-24

    申请人： High Throughput Genomics, Inc.

    发明人： KRCHNAK, Viktor,High Throughput Genomics, Inc ,  VAGNER, Josef,High Throughput Genomics, Inc ,  SELIGMANN, Bruce A.,High Throughput Genomics, Inc

    IPC分类号： G01N31/00

    CPC分类号： B01J19/0046 ,  B01L3/02 ,  B01L3/502

    摘要： A sorting apparatus and method for directed sort combinatorial chemical synthesis is provided. This invention relates to a directed flexible, sorting apparatus and method for combinatorial chemical synthesis using a directed split and recombine process. The process utilizes one algorithm that is universal in directing and sorting a library of any size. This invention further provides a method of sorting solid supports for combinatorial chemical synthesis comprising delivering one or more supports which are organized in a one dimensional linear array in one or more reaction vessels, to an isolation and transfer chamber, transferring one or more support from each of said reaction vessels to one or more subsequent reaction vessels, in a patterned distribution; wherein the patterned distribution of supports in each subsequent transfer is identical and the position of each support in a reaction vessel codes for its previous synthesis history. In another aspect, the invention provides a directed sort apparatus wherein all members of a set at a given point in time are reacted with the same chemical building blocks throughout synthesis.

    STABILIZATION OF RADIONUCLIDE-CONTAINING COMPOSITIONS
    5.
    发明公开
    STABILIZATION OF RADIONUCLIDE-CONTAINING COMPOSITIONS 有权
    稳定价格含放射性核素组合物

    公开(公告)号：EP1401507A2

    公开(公告)日：2004-03-31

    申请号：EP02726875.4

    申请日：2002-05-16

    申请人： SCHERING AKTIENGESELLSCHAFT

    发明人： MANCHANDA, Rajesh

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K51/08 ,  A61K51/04

    摘要： Described are methods for stabilizing radionuclide-containing compositions against degradation caused by free radicals generated from the radionuclide. Iodide ions stabilize the radionuclide-containing compositions by acting as scavengers to generated free radicals, thus, preventing or lessening degradation therefrom. Among the preferred radionuclide-containing compositions to be stabilized are complexes of a complexing agent with a radionuclide complexed therewith, such as a diagnostic agent having a specific binding peptide linked to a metal ion-complexing moiety which is complexed with a radionuclide, such as technetium-99m (Tc-99m). Also included in the invention are compositions of radionuclide-containing compounds or complexes with iodide or an iodide ion-providing component, compositions of compounds or complexing agents that will be associated with a radionuclide and kits containing any combination of radionuclides, radionuclide generators, complexing agents or compounds which are associated with or will be associated with radionuclides and iodide or iodide-providing components.

    METHOD OF MEASURING CONCENTRATION OF SILANOL GROUP AND CELL FOR MEASUREMENT
    7.
    发明公开
    METHOD OF MEASURING CONCENTRATION OF SILANOL GROUP AND CELL FOR MEASUREMENT 有权
    VERFAHREN ZUR MESSUNG EINER SILANOLGRUPPE

    公开(公告)号：EP1530038A1

    公开(公告)日：2005-05-11

    申请号：EP03784604.5

    申请日：2003-08-08

    申请人： TOAGOSEI CO., LTD.

    发明人： KIMATA, Yoshinori, Toagosei Co., Ltd.,

    IPC分类号： G01N21/35 ,  G01N21/03

    CPC分类号： G01N21/3504 ,  G01N21/0317 ,  G01N21/05 ,  G01N2021/115

    摘要： The object of the present invention is to measure the silanol group concentration in silicon compound, rapidly and at a high accuracy by infrared spectrophotometry. A silicon compound, when comes in contact with, for example, water in the air, reacts therewith immediately, forming a silanol group. Therefore, in measurement of the silanol group concentration in silicon compound, it is necessary that the sample to be measured is not contacted with the air and that the very small amount of water adhering to the inside of a sample cell is removed completely.
    In the present invention, the removal of water inside the cell in a short time has been made possible by use of a pressure-resistant cell.
    The first aspect of the present invention lies in:

    a method for measurement of silanol group concentration in silicon compound by infrared spectrophotometry, which comprises:

    conducting, prior to filling of a silicon compound in a cell, at least twice each of a step of keeping the cell inside at 20 Pa or lower and a step of keeping the cell inside at 0.2 to 1 MPa,
    then, introducing the silicon compound into the cell and measuring the infrared absorption spectrum thereof, to measure the concentration of the silanol group in the silicon compound.


    The second aspect of the present invention lies in:

    a cell used for measurement of infrared absorption spectrum, which can withstand a reduced pressure of 20 Pa or lower and a pressure of 0.2 to 1 MPa.

    摘要翻译： 本发明的目的是通过红外分光光度法快速且高精度地测量硅化合物中的硅烷醇基浓度。 硅化合物当与例如空气中的水接触时立即与其反应，形成硅烷醇基团。 因此，在测定硅化合物中的硅烷醇基浓度时，被测定体不必与空气接触，并且完全除去附着在样品池内部的极少量的水。 在本发明中，通过使用耐压池，可以在短时间内除去电池内的水。 本发明的第一方面在于：通过红外分光光度法测定硅化合物中的硅烷醇基浓度的方法，其包括：在将硅化合物填充到电池中之前进行至少两次 将电池内部保持在20Pa以下的步骤和将电池内部保持在0.2〜1MPa的步骤，然后将硅化合物引入电池并测量其红外吸收光谱，测量硅烷醇的浓度 在硅化合物中。 本发明的第二方面在于：用于测量红外吸收光谱的电池，其能够承受20Pa以下的压力和0.2〜1MPa的压力。