公开(公告)号：EP1904069B1

公开(公告)日：2018-06-13

申请号：EP06787476.8

申请日：2006-07-17

申请人： Albany Molecular Research, Inc. ,  Bristol-Myers Squibb Company

发明人： MOLINO, Bruce, F. ,  LIU, Shuang ,  SAMBANDAM, Aruna ,  GUZZO, Peter, R. ,  HU, Min ,  ZHA, Congxiang ,  NACRO, Kassoum ,  MANNING, David, D. ,  ISHERWOOD, Matthew, L. ,  FLEMING, Kristen, N. ,  CUI, Wenge ,  OLSON, Richard, E.

IPC分类号： A61P25/00 ,  A61K31/55 ,  C07D223/16

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.

公开(公告)号：EP1689395B1

公开(公告)日：2016-02-17

申请号：EP04813012.4

申请日：2004-12-03

申请人： Albany Molecular Research, Inc.

发明人： SCOTT, Ian, L. ,  RALPH, Jeffrey, M. ,  VOSS, Matthew, E.

IPC分类号： A61K31/44 ,  A61P35/00 ,  C07D487/00

CPC分类号： C07D519/04

公开(公告)号：EP2668191A2

公开(公告)日：2013-12-04

申请号：EP12736835.5

申请日：2012-01-18

申请人： Albany Molecular Research, Inc.

发明人： GUZZO, Peter, R. ,  HENDERSON, Alan, J. ,  ISHERWOOD, Matthew ,  LEE, Chong, Yew ,  GHOSH, Animesh ,  ZHAO, He, River

IPC分类号： C07D491/04 ,  C07D307/91 ,  A61K31/4741 ,  A61P25/00

CPC分类号： C07D491/048 ,  C07D307/91 ,  C07D491/08 ,  C07D491/18

摘要： The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

公开(公告)号：EP2586778A2

公开(公告)日：2013-05-01

申请号：EP12196756.6

申请日：2008-03-12

申请人： Merck Sharp & Dohme Corp. ,  Albany Molecular Research, Inc.

发明人： Ting, Pauline, C. ,  Aslanian, Robert, G. ,  Cao, Jainhua ,  Kim, David, Won-Shik ,  Kuang, Rongze ,  Zhou, Gang ,  Herr, Robert, Jason ,  Zych, Andrew, John ,  Yang, Jinhai ,  Wu, Heping ,  Zorn, Nicolas

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D515/22 ,  A61K31/501 ,  A61P31/00

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D515/22

摘要： In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了作为葡聚糖合酶抑制剂的取代的哒嗪酮化合物，制备此类化合物的方法，包括一种或多种此类化合物的药物，制备包含一种或多种此类化合物或一种或多种此类化合物 以及其他抗真菌剂，以及使用此类化合物或药物组合物治疗，预防，抑制或改善与葡聚糖合酶相关的一种或多种真菌感染的方法。

公开(公告)号：EP2280956A2

公开(公告)日：2011-02-09

申请号：EP09759418.8

申请日：2009-06-04

申请人： Bristol-Myers Squibb Company ,  Albany Molecular Research, Inc.

发明人： LOBBEN, Paul ,  ZHAO, Rulin ,  WANG, Bei ,  CHEN, Bang-chi ,  LIU, Shuang ,  HU, Min ,  YANG, Yuh-Lin, Allen ,  ISHERWOOD, Matthew ,  AMIN, Rasidul ,  CUI, Wenge

IPC分类号： C07D401/04

CPC分类号： C07F5/04 ,  C07C215/20 ,  C07C217/58 ,  C07C223/02 ,  C07D217/04 ,  C07D237/20 ,  C07D401/04 ,  C07D413/10 ,  C07F5/022 ,  C07F5/025

摘要： Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.

公开(公告)号：EP2125826A1

公开(公告)日：2009-12-02

申请号：EP08727467.6

申请日：2008-01-09

申请人： Albany Molecular Research, Inc.

发明人： GUZZO, Peter ,  SURMAN, Matthew David

IPC分类号： C07D491/048 ,  A61K31/4355 ,  A61P3/04 ,  A61P25/22 ,  A61P25/24

CPC分类号： C07D491/048

摘要： Compounds are disclosed. The compounds act as MCH1 modulators. Other embodiments are also disclosed.

摘要翻译： 公开了化合物。 这些化合物充当MCH1调节剂。 其他实施例也被公开。

公开(公告)号：EP2121654A1

公开(公告)日：2009-11-25

申请号：EP08713668.5

申请日：2008-01-09

申请人： Albany Molecular Research, Inc.

发明人： GUZZO, Peter ,  SURMAN, Matthew David ,  HENDERSON, Alan John ,  HADDEN, Mark ,  JIANG, May Xiaowu

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D498/08 ,  A61K31/4439 ,  A61P3/04 ,  A61P25/22 ,  A61P25/24

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D498/08

摘要： Various 5-substituted 1-substituted indazoles are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.

公开(公告)号：EP2027088A2

公开(公告)日：2009-02-25

申请号：EP07753404.8

申请日：2007-03-16

申请人： The Government of the United States of America, as repres. by the Secretary of Health and Human Services, Nat. Inst. of Health ,  Albany Molecular Research, Inc. ,  SCIENCE APPLICATIONS INTERNATIONAL CORPORATION

发明人： HEEMSKERK, Jill ,  BARNES, Keith, D. ,  MCCALL, John, M. ,  JOHNSON, Graham ,  FAIRFAX, David ,  JOHNSON, Matthew, Robert

IPC分类号： C07D209/46 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

CPC分类号： C07D209/46 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

摘要： Compounds of Formula (I) or (Il) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.

公开(公告)号：EP1603512A2

公开(公告)日：2005-12-14

申请号：EP04757551.9

申请日：2004-03-16

申请人： Albany Molecular Research, Inc.

发明人： MOLINO, Bruce, F. ,  HAYDAR, Simon, N. ,  YANG, Zhicai ,  MICHELS, Peter, C. ,  HEMENWAY, Michael, S. ,  RICH, Joseph, O. ,  KHMELNITSKY, Yuri

IPC分类号： A61K6/00

CPC分类号： C07K7/645

摘要： The compounds of the present invention are represented by the chemical structure found in Formula I: where A is an amino acid of Formula II: or a pharmaceutically acceptable salt thereof, with R0, R1, B, C, D, E, F, G, H, I, J, and K defined herein.

公开(公告)号：EP0723958A1

公开(公告)日：1996-07-31

申请号：EP96200338.0

申请日：1994-06-21

申请人： ALBANY MOLECULAR RESEARCH, INC.

发明人： D'Ambra, Thomas E.

IPC分类号： C07D211/22 ,  C07D211/32 ,  C07D221/20 ,  C07C59/86 ,  C07C69/738

CPC分类号： C07D211/20 ,  C07C59/86 ,  C07C69/738 ,  C07D211/22 ,  C07D211/32

摘要： The present invention relates to substantially pure piperidine derivative compounds of formulae (I) or (II)

wherein R 1 is hydrogen or hydroxy; R 2 is hydrogen; or R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 ; R 3 is -COOH or -COOR 4 ; R 4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents.

摘要翻译： 本发明涉及式（I）或（II）基本上纯的哌啶衍生物化合物，其中R 1是氢或羟基; R2是氢; 或者R 1和R 2一起形成带有R 1和R 2的碳原子之间的第二个键; R3是-COOH或-COOR4; R4具有1至6个碳原子; A，B和D是它们各自的环的取代基，其各自可以是不同的或相同的，并且是氢，卤素，烷基，羟基，烷氧基或其它取代基。