公开(公告)号：EP2034985A1

公开(公告)日：2009-03-18

申请号：EP07803849.4

申请日：2007-07-05

申请人： Université de la Méditerranée - Aix-Marseille II ,  Association Francaise Contre Les Myopathies (AFM) ,  Assistance Publique Hopitaux de Marseille ,  Universidad De Oviedo

发明人： LEVY, Nicolas ,  CAU, Pierre ,  LOPEZ-OTIN, Carlos

IPC分类号： A61K31/22 ,  A61K31/663 ,  A61P17/00 ,  A61P43/00

CPC分类号： A61K31/675 ,  A61K8/4913 ,  A61K8/498 ,  A61K8/55 ,  A61K31/215 ,  A61K31/22 ,  A61K31/663 ,  A61Q19/08 ,  A61K2300/00

摘要： The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.

公开(公告)号：EP0998945A1

公开(公告)日：2000-05-10

申请号：EP98402424.0

申请日：1998-09-30

申请人： TRANSGENE S.A. ,  ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES

发明人： Braun, Serge

IPC分类号： A61K48/00

CPC分类号： A61K48/00

摘要： Described is the use of magnesium (Mg 2+ ) for the preparation of a therapeutic composition for the introduction of a polynucleotide into a cell in vivo.

摘要翻译： 描述了镁（Mg 2+）用于制备用于在体内将多核苷酸引入细胞的治疗组合物的用途。

公开(公告)号：EP0980263A1

公开(公告)日：2000-02-23

申请号：EP98928391.6

申请日：1998-05-29

申请人： TRANSGENE S.A. ,  ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES

发明人： BRAUN, Serge

IPC分类号： A61K48/00

CPC分类号： A61K48/00 ,  C12N15/87

摘要： The invention concerns a combined product comprising at least a substance breaking up a cell extracellular matrix and at least a nucleic acid of interest, to be administered simultaneously, consecutively or spread over time, said nucleic acid being carried by an infectious viral particle or in the form of a synthetic vector. The invention also concerns the use of said product for therapeutic or vaccine purposes to prepare a medicine for treating the human or animal body using gene therapy and the use of a substance breaking up the extracellular matrix to improve the transfer and/or the expression of said nucleic acid of interest in a host cell or organism.

公开(公告)号：EP2921172B1

公开(公告)日：2018-09-12

申请号：EP15160222.4

申请日：2007-07-05

申请人： Université d'Aix-Marseille ,  Association Francaise Contre Les Myopathies (AFM) ,  Assistance Publique Hôpitaux de Marseille ,  Universidad de Oviedo

发明人： Levy, Nicolas ,  Cau, Pierre ,  Lopez-Otin, Carlos

IPC分类号： A61K31/215 ,  A61K31/22 ,  A61K31/663 ,  A61K31/675 ,  A61P17/00 ,  A61P19/00 ,  A61P43/00

CPC分类号： A61K31/675 ,  A61K8/4913 ,  A61K8/498 ,  A61K8/55 ,  A61K31/215 ,  A61K31/22 ,  A61K31/663 ,  A61Q19/08 ,  A61K2300/00

公开(公告)号：EP3244909A1

公开(公告)日：2017-11-22

申请号：EP16700619.6

申请日：2016-01-14

申请人： Université d'Aix Marseille ,  Assistance Publique Hôpitaux de Marseille ,  INSERM - Institut National de la Santé et de la Recherche Médicale ,  Association Francaise Contre Les Myopathies ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- ,  Progelife

发明人： LEVY, Nicolas ,  CAU, Pierre ,  DE SANDRE-GIOVANNOLI, Annachiara ,  HARHOURI, Karim ,  PERRIN, Sophie ,  NAVARRO, Claire ,  CHARTIER, Aymeric ,  SIMONELIG, Martine

IPC分类号： A61K38/06 ,  A61K8/64 ,  A61P43/00

CPC分类号： A61K38/06 ,  A61K8/64 ,  A61Q19/08

摘要： The invention relates to a proteasome inhibitor for use for treating and/or preventing a disorder related to an accumulation of a non-degraded abnormal protein, particularly a premature ageing disorder. The invention also relates to the use of proteasome inhibitors for attenuating physiological ageing. The invention also relates to the use of proteasome inhibitors in the treatment and/or prevention of age-related disorders and their metabolic consequences. The invention also relates to the dermato logical, dermo cosmetic or cosmetic use of a proteasome inhibitor for preventing and/or attenuating skin ageing. The invention also relates to the use of proteasome inhibitors in the treatment of cancer.

公开(公告)号：EP3204380A1

公开(公告)日：2017-08-16

申请号：EP15775223.9

申请日：2015-10-07

申请人： Institut National de la Santé et de la Recherche Médicale ,  Association Francaise Contre Les Myopathies ,  Universite d'Evry Val d'Essonne

发明人： PESCHANSKI, Marc ,  BLONDEL, Sophie ,  NISSAN, Xavier

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D401/02 ,  A61K31/506 ,  A61P25/00 ,  A61P3/00 ,  A61P35/00 ,  A61P9/00 ,  A61P31/12

CPC分类号： C07D409/14 ,  C07D401/02 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14

摘要： group. Also disclosed are novel compounds of formulae (I) and (II).

摘要翻译： 本发明涉及用于治疗和/或预防其中需要抑制蛋白质异戊烯化的疾病或病症的化合物，其可选地选自式（I）和（II），其中R 1是2-吡啶基 ，3-吡啶基或4-吡啶基; R2代表式（III），（IV）和（V）; 并且其中R5和R6代表氢原子或（C1-4）烷基; R7表示芳基羰基，杂芳基羰基，杂芳基乙酰基，（C1-C4）烷氧基羰基甲基，式（VI）基。 还公开了新的式（I）和（II）的化合物。

公开(公告)号：EP2780457A1

公开(公告)日：2014-09-24

申请号：EP12787764.5

申请日：2012-10-15

申请人： Association Francaise Contre les Myopathies

发明人： KICHLER, Antoine ,  SCHERMAN, Daniel

IPC分类号： C12N15/12 ,  C07K14/47 ,  A61K38/17 ,  A61K38/18

CPC分类号： C07K14/4725 ,  A61K38/10 ,  A61K38/1709 ,  A61K38/177 ,  C07K7/08 ,  C07K9/00 ,  C07K14/705

摘要： The invention relates to the use of fibromodulin and lumican, in particular the active fragments thereof, for increasing muscle mass, in particular in the treatment of muscular dystrophy.

摘要翻译： 本发明涉及纤维调节蛋白和lumican，尤其是其活性片段在增加肌肉质量，特别是在治疗肌营养不良中的用途。

公开(公告)号：EP2408469A1

公开(公告)日：2012-01-25

申请号：EP10715955.0

申请日：2010-03-18

申请人： Association Francaise Contre les Myopathies

发明人： KICHLER, Antoine ,  SCHERMAN, Daniel

IPC分类号： A61K38/17 ,  A61K48/00 ,  A61P21/00 ,  A23L1/29

CPC分类号： A61K38/1709 ,  A61K45/06

摘要： The invention relates to decorin for increasing muscle mass, in particular in the treatment of muscular dystrophies.

公开(公告)号：EP1292671B9

公开(公告)日：2010-05-19

申请号：EP01943584.1

申请日：2001-06-07

申请人： ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES

发明人： VILQUIN, Jean-Thomas ,  MAROLLEAU, Jean-Pierre ,  TREMBLAY, Jacques ,  ROBERT, Isabelle ,  TERNAUX, Brigitte

IPC分类号： C12N5/08 ,  C12N5/10 ,  A61K48/00 ,  A61P9/00 ,  A61P19/00 ,  A61P21/00

CPC分类号： C12N5/0658 ,  A61K35/12 ,  A61K48/00 ,  C12N2501/115

摘要： The invention concerns a method for obtaining cell populations derived from the muscular tissue and their use for preparing cell therapy products. It consists in particular in culturing cells previously removed by biopsy from skeletal muscular tissues, identifying the different types of cells present at different stages of culture, selecting the culture stage on the basis of the required cell population and collecting the selected culture stage for preparing a cell therapy product. The invention also concerns cell populations derived from muscular tissue obtained by implementing said method whereof the dominant cell type is CD34+, CD15+ or CD56+ or Class 1+ HLA, or comprises a doubly negative CD56-/CD15- cell type or may comprise more minority CD10+, Stro-1+ and CD117+ cell types.

公开(公告)号：EP0792364B1

公开(公告)日：2005-09-21

申请号：EP95938456.1

申请日：1995-11-21

申请人： ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES

发明人： BECKMANN, Jacques ,  RICHARD, Isabelle

IPC分类号： C12N15/57 ,  C12N9/64 ,  A61K38/48 ,  G01N33/50 ,  C12Q1/68 ,  C12N5/10 ,  A61K48/00

CPC分类号： C12N9/6472 ,  A61K38/00

摘要： A nucleic acid sequence comprising: 1) the sequence represented in figure 8; or 2) the sequence represented in figure 2; or 3) a part of the sequence of figure 2 with the proviso that it is able to code for a protein having a calcium dependant protease activity involved in a LGMD2; or 4) a sequence derived from a sequence defined in 1), 2) or 3) by substitution, deletion or addition of one or more nucleotides with the proviso that said sequences still codes for said protease.