摘要:
Oviedomycin derivatives, method for obtaining same and use thereof. This invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce the oviedomycin derivatives. The invention further relates to bacterial strains that can be used to produce oviedomycin derivatives. Finally, said oviedomycin derivatives are applicable in the field of the human health, specifically to produce drugs for the treatment of tumour diseases.
摘要:
Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms ( Streptomyces spp .) . Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus , achieving production of rebeccamycin and derivatives. To be applied in the pharmaceutical field.
摘要:
Production of the structural antigen (VP60) of the virus of the hemorrhagic disease of the rabbits, RHDV, and its use as a vaccine against said disease. The production of the antigen and the method of vaccination comprise the following stages: a) isolation of the gene that code the structural protein (VP60) of the RHDV; b) cloning of said gene in the baculovirus transfer vector pAcYM1; c) obtention and isolation of the recombinant baculovirus AcVP60; d) infection of Sf9 insect cells with the recombinant baculovirus AcVP60; e) obtention and isolation of the protein VP60 produced by the recombinant baculovirus AcVP60; f) inoculation of the rabbits with the antigen.
摘要:
Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.
摘要:
The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).
摘要:
The invention relates to the quantification of organic compounds originating from a chromatographic system that does not involve the use of patterns, comprising the continuous conversion of the carbon of said compounds into carbon dioxide (CO2) involving a chemical reaction and the mixing of same, before or after separation, with a known, constant flow of a carbon compound, preferably CO2, which is enriched with carbon isotope-13 ( 13 C). The mixture is introduced into a mass spectrometer in which the isotopic ratio 12 C/ 13 C is continuously measured either in the carbon or in any characteristic ion originating from same. Said isotopic ratio is converted into a carbon mass flow measurement using in-line isotopic dilution.
摘要翻译:本发明涉及来自不涉及图案使用的色谱系统的有机化合物的定量,其包括将所述化合物的碳连续转化为涉及化学反应的二氧化碳(CO 2),并将其混合,然后 或分离后,用已知的恒定流量的碳化合物,优选富含碳同位素-13(13C)的CO 2。 将混合物引入质谱仪中,其中在碳或任何来自其的特征离子中连续测量同位素比12 C / 13 C。 使用在线同位素稀释将所述同位素比转化为碳质量流量测量。
摘要:
The present invention is directed to methods for the preparation of 3' 0 and 5' 0- levulinyl nucleosides from common precursors using an enzymatic approach.