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    METHOD OF PROLIFERATING PLURIPOTENT STEM CELL
    2.
    发明公开
    METHOD OF PROLIFERATING PLURIPOTENT STEM CELL 有权
    VERFAHREN ZUR PROLIFEATION EINER PLURPOTENTEN STAMMZELLE

    公开(公告)号：EP1734112A1

    公开(公告)日：2006-12-20

    申请号：EP05727500.0

    申请日：2005-03-23

    申请人： Daiichi Asubio Pharma Co., Ltd. ,  Fukuda, Keiichi ,  Akaike, Toshihiro

    发明人： AKAIKE, Toshihiro ,  FUKUDA, Keiichi ,  NAGAOKA, Masato ,  KOSHIMIZU, Uichi;

    IPC分类号： C12N5/06 ,  C12N5/08 ,  C07K14/47 ,  C12N15/09

    CPC分类号： C12N5/0606 ,  C12N2533/50

    摘要： A novel growth method is provided for pluripotent stem cells such as ES cells. The method of the invention is a pluripotent stem cell growing method and gene transfer method in which pluripotent stem cells are cultured under conditions that maintain their undifferentiated state and pluripotency, the method being characterized by using a liquid medium and a culturing vessel having immobilized or coated on a substrate solid phase surface a molecule which is adhesive to the pluripotent stem cells in a fixed concentration, to grow the pluripotent stem cells in a dispersed state while maintaining their undifferentiated state and pluripotency, without using feeder cells, or to transfer and express a gene therein.

    摘要翻译： 为多能干细胞如ES细胞提供了一种新的生长方法。 本发明的方法是多能干细胞生长方法和基因转移方法，其中多能干细胞在保持其未分化状态和多能性的条件下培养，该方法的特征在于使用液体培养基和具有固定或涂覆的培养容器 在底物固相表面上以固定浓度与多能干细胞粘合的分子，以分散状态生长多能干细胞，同时保持其未分化状态和多能性，而不使用饲养细胞，或转移和表达 基因。

    MRI CONTRAST MEDIA RECOGNIZING MINOR ENVIRONMENTAL CHANGES
    4.
    发明公开
    MRI CONTRAST MEDIA RECOGNIZING MINOR ENVIRONMENTAL CHANGES 失效
    MRI-KONTRASTMITTELNZUR ERKENNUNG VON MINEURE

    公开(公告)号：EP1034796A1

    公开(公告)日：2000-09-13

    申请号：EP98907246.7

    申请日：1998-03-16

    申请人： NIHON SCHERING K. K. ,  Akaike, Toshihiro

    发明人： AKAIKE, Toshihiro ,  MIKAWA, Masahito ,  MARUYAMA, Atsushi ,  MIWA, Naoto

    IPC分类号： A61K49/00

    CPC分类号： A61K49/085 ,  A61K49/12 ,  A61K49/128

    摘要： This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in response to environmental changes, particularly, pH, light or temperature, to develop a different water solubility, and a method for imaging by the use of this contrast medium. By binding a polymer responsive to microenvironmental changes with a Gd type MRI contrast agent, on-off switching of MRI imaging capability is enabled, wherein imaging occurs only on the target sites. Consequently, a highly specific MRI contrast medium can be obtained, whereby a highly specific MRI diagnosis is made possible, wherein only the target sites such as a tumor and a particular site are imaged and otherwise at the site where imaging is not necessary.

    摘要翻译： 这涉及含有钆（Gd）型造影剂和聚合物的复合物的造影剂。 更具体地，其中响应于环境变化，特别是pH，光或温度相变转移以形成不同水溶性的聚合物的造影剂，以及通过使用该造影剂进行成像的方法。 通过用Gd型MRI造影剂结合响应于微环境变化的聚合物，能够进行MRI成像能力的开 - 关切换，其中成像仅在靶位点上发生。 因此，可以获得高度特异性的MRI造影剂，由此可以进行高度特异性的MRI诊断，其中只有目标部位如肿瘤和特定部位成像，否则在不需要成像的部位进行成像。