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1.发明公开METHOD OF INDUCING DIFFERENTIATION INTO MYOCARDIAL CELLS USING G-CSF 有权VERFAHREN ZUR EINLEITUNG VON DIFFERENZIERUNG在MYKARDIALE ZELLEN MITTELS G-CSF
公开(公告)号：EP2154242A1
公开(公告)日：2010-02-17
申请号：EP08765549.4
申请日：2008-06-06
申请人： Fukuda, Keiichi
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
摘要： A method for inducing differentiation of ES cells into cardiomyocytes, which comprises contacting the ES cells with an agonist for G-CSF receptor.
摘要翻译： 一种诱导ES细胞分化为心肌细胞的方法，其包括将ES细胞与G-CSF受体的激动剂接触。
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2.发明公开REMEDY FOR ANGIOGENESIS-RELATED DISEASE COMPRISING CHONDROMODULIN-I AS THE ACTIVE INGREDIENT 审中-公开MEANS血管生成有关的疾病与软骨调节，我积极治疗
公开(公告)号：EP1946765A4
公开(公告)日：2009-10-21
申请号：EP06810198
申请日：2006-09-15
申请人： FUKUDA KEIICHI , HIRAKI YUJI
发明人： FUKUDA KEIICHI , HIRAKI YUJI
IPC分类号： A61K38/00 , A01K67/027 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P27/02 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： A61K48/005 , A01K2217/075 , A01K2267/03 , A61K31/7088 , A61K38/00 , C07K14/51 , G01N33/502 , G01N2800/32
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公开(公告)号：EP2641609A4
公开(公告)日：2014-07-23
申请号：EP11841477
申请日：2011-11-17
申请人： FUKUDA KEIICHI
发明人： FUKUDA KEIICHI , YUASA SHINSUKE
CPC分类号： A61K38/193
摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.
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公开(公告)号：EP2641609A1
公开(公告)日：2013-09-25
申请号：EP11841477.0
申请日：2011-11-17
申请人： Fukuda, Keiichi
发明人： FUKUDA, Keiichi. , YUASA, Shinsuke.
CPC分类号： A61K38/193
摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.
摘要翻译： 本发明提供了与骨骼肌变性相关的疾病的治疗剂，其包含粒细胞集落刺激因子（G-CSF）作为活性成分。 本发明的治疗剂作为肌营养不良症的治疗剂是特别有效的。
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5.发明公开REMEDY FOR ANGIOGENESIS-RELATED DISEASE COMPRISING CHONDROMODULIN-I AS THE ACTIVE INGREDIENT 审中-公开MITTEL ZUR BEHANDLUNG VON ANGIOGENESE-BEDINGTEN ERKRANKUNGEN MIT CHONDROMODULIN-I ALS WIRKSTOFF
公开(公告)号：EP1946765A1
公开(公告)日：2008-07-23
申请号：EP06810198.9
申请日：2006-09-15
申请人： Fukuda, Keiichi , Hiraki, Yuji
发明人： Fukuda, Keiichi , Hiraki, Yuji
IPC分类号： A61K38/00 , A01K67/027 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P27/02 , A61P43/00 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , C12N15/09
CPC分类号： A61K48/005 , A01K2217/075 , A01K2267/03 , A61K31/7088 , A61K38/00 , C07K14/51 , G01N33/502 , G01N2800/32
摘要： An objective of the present invention is to analyze the function of anti-angiogenic factors in cardiac valves or such to elucidate the developmental mechanism of angiogenesis-induced diseases. A more specific objective is to provide therapeutic agents for angiogenesis-induced diseases such as valvular heart disease, and methods of efficiently screening for the therapeutic agents. The present inventors discovered that chondromodulin-I was markedly expressed in cardiac valves, and plays an important role in maintaining normal functions of the valves by preventing angiogenesis, thickening, and calcification which lead to valvular heart diseases. Chondromodulin-I proteins and substances that activate the expression or function of the proteins are expected to have therapeutic effects against angiogenesis-induced diseases.
摘要翻译： 本发明的目的是分析心脏瓣膜中的抗血管生成因子的功能，以阐明血管生成诱发的疾病的发展机制。 更具体的目的是提供血管生成诱导的疾病如瓣膜性心脏病的治疗剂和有效筛选治疗剂的方法。 本发明人发现软骨调节蛋白-1在心脏瓣膜中显着表达，并且通过预防血管生成，增厚和钙化导致瓣膜性心脏病的维持瓣膜的正常功能起重要作用。 软骨调节蛋白-1蛋白质和激活蛋白质表达或功能的物质预期具有对血管生成诱导的疾病的治疗作用。
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6.发明授权METHOD OF INDUCING DIFFERENTIATION INTO MYOCARDIAL CELLS USING G-CSF 有权METHOD FOR引言差分在心肌细胞中的使用的G-CSF
公开(公告)号：EP2154242B1
公开(公告)日：2016-01-06
申请号：EP08765549.4
申请日：2008-06-06
申请人： Fukuda, Keiichi
IPC分类号： A61K35/12 , C12N5/0735 , C12N5/077
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
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7.发明公开METHOD OF INDUCING DIFFERENTIATION INTO MYOCARDIAL CELLS USING G-CSF 有权METHOD FOR引言差分在心肌细胞中的使用的G-CSF
公开(公告)号：EP2154242A4
公开(公告)日：2011-08-10
申请号：EP08765549
申请日：2008-06-06
申请人： FUKUDA KEIICHI
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
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8.发明公开
公开(公告)号：EP1674562A4
公开(公告)日：2007-04-11
申请号：EP04792009
申请日：2004-10-04
申请人： FUKUDA KEIICHI
发明人： FUKUDA KEIICHI , YUASA SHINSUKE , OKANO HIDEYUKI , SHIMAZAKI TAKUYA , KOSHIMIZU UICHI , TANAKA TOMOFUMI , SUGIMURA KEIJIRO
IPC分类号： C12N5/077 , C12N15/06 , C12N5/071 , C12N5/0735 , C12N5/074 , C12N5/0789
CPC分类号： C12N5/0657 , C12N2501/155 , C12N2506/03
摘要： It is intended to provide a method of inducing the differentiation of stem cells into myocardial cells characterized in that the induction of the differentiation of stem cells into myocardial cells is carried out by culturing the stem cells in the presence of a substance inhibiting the BMP signal transfer to thereby efficiently and selectively induce the differentiation into myocardial cells.
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公开(公告)号：EP1734112A4
公开(公告)日：2007-09-05
申请号：EP05727500
申请日：2005-03-23
IPC分类号： C12N5/0789 , C07K14/47 , C12N5/071 , C12N15/09
CPC分类号： C12N5/0606 , C12N2533/50
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10.发明公开METHOD OF INDUCING THE DIFFERENTIATION OF STEM CELLS INTO MYOCARDIAL CELLS 审中-公开VERFAHREN ZUR INDUZIERUNG DER DIFFERENZIERUNG VON STAMMZELLEN ZU MYOKARDZELLEN
公开(公告)号：EP1674562A1
公开(公告)日：2006-06-28
申请号：EP04792009.5
申请日：2004-10-04
申请人： Fukuda, Keiichi
发明人： FUKUDA, Keiichi , YUASA, Shinsuke , OKANO, Hideyuki , SHIMAZAKI, Takuya , KOSHIMIZU, Uichi , TANAKA, Tomofumi , SUGIMURA, Keijiro
CPC分类号： C12N5/0657 , C12N2501/155 , C12N2506/03
摘要： For a method of inducing differentiation of cardiomyocytes from stem cells, a method is provided to induce efficiently and selectively differentiation of cardiomyocytes by such a method in which the stem cells are cultured to induce differentiation into cardiomyocytes in the presence of a substance that inihibits BMP signaling.
摘要翻译： 为了诱导心肌细胞从干细胞分化的方法，提供了一种通过这样一种方法诱导心肌细胞的有效和选择性分化的方法，其中在存在抑制BMP信号的物质的情况下培养干细胞以诱导分化成心肌细胞 。
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