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公开(公告)号：EP4230288A2
公开(公告)日：2023-08-23
申请号：EP23178106.3
申请日：2012-10-24
申请人： Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University , Engineering Arts LLC
发明人： WIKTOR, Peter , LABAER, Joshua , KAHN, Peter , TAKULAPALLI, Bharath , QIU, Ji , BRUNNER, All , MAGEE, Mitch
摘要： Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography.
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公开(公告)号：EP3002744B1
公开(公告)日：2018-10-24
申请号：EP15188968.0
申请日：2014-03-12
发明人： KOZICKI, Michael, N.
IPC分类号： G09C1/00 , H04L9/32 , G06K9/62 , G06K9/46 , G01N21/21 , G02B21/06 , G02B21/36 , G02B27/28 , G09C5/00
CPC分类号： G06K7/1099 , G02B21/06 , G02B21/365 , G02B27/286 , G06F17/3028 , G06F17/30879 , G06K9/00147 , G06K9/00577 , G06K9/2027 , G06K9/46 , G06K9/4671 , G06K9/6202 , G06K19/06046 , G06K19/07749 , G06K19/086 , G06T7/0012 , G06T7/12 , G06T2207/10056 , G06T2207/30024 , G09C5/00 , H04L9/3278 , H04L2209/12
摘要： The disclosure features dendritic tags, and methods and systems for fabricating and using such tags. The methods can include obtaining at least one image of a dendritic tag attached to an article, analyzing the at least one image to identify a set of features associated with the dendritic tag, and comparing the set of features to stored information to identify the article.
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公开(公告)号：EP2998949B1
公开(公告)日：2018-10-24
申请号：EP15188964.9
申请日：2014-03-12
发明人： KOZICKI, Michael, N.
CPC分类号： G06K7/1099 , G02B21/06 , G02B21/365 , G02B27/286 , G06F17/3028 , G06F17/30879 , G06K9/00147 , G06K9/00577 , G06K9/2027 , G06K9/46 , G06K9/4671 , G06K9/6202 , G06K19/06046 , G06K19/07749 , G06K19/086 , G06T7/0012 , G06T7/12 , G06T2207/10056 , G06T2207/30024 , G09C5/00 , H04L9/3278 , H04L2209/12
摘要： The disclosure features dendritic tags, and methods and systems for fabricating and using such tags. The methods can include obtaining at least one image of a dendritic tag attached to an article, analyzing the at least one image to identify a set of features associated with the dendritic tag, and comparing the set of features to stored information to identify the article.
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公开(公告)号：EP2694478B1
公开(公告)日：2018-08-22
申请号：EP12713835.2
申请日：2012-04-04
IPC分类号： C07D213/74 , A61K31/64 , A61P39/06
CPC分类号： C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
摘要： The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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5.发明公开1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE DERIVATIVES USEFUL AS RXR MODULATORS FOR TREATING ALZHEIMER'S DISEASE AND CANCER 审中-公开1,2,3,4-四氢-1,1,4,4-四甲基苯基乙酸酯ALR RXR-MODULATOREN ZUR BEHANDLUNG VON ALZHEIMER-KRANKHEIT UND KREBS
公开(公告)号：EP2910549A1
公开(公告)日：2015-08-26
申请号：EP15154401.2
申请日：2012-09-13
IPC分类号： C07D239/28 , A61K31/505 , A61P35/00 , A61P25/00
CPC分类号： A61K31/505 , C07C57/50 , C07C57/62 , C07C59/54 , C07C2602/10 , C07D213/55 , C07D213/80 , C07D239/28
摘要： The invention provides compounds of formula II:
and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.摘要翻译： 本发明提供式II化合物及其盐，以及包含这些化合物的药物组合物。 该化合物可用于治疗癌症和阿尔茨海默病。
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6.发明公开NANOSCALE PROCESS TO GENERATE REAGENTS SELECTIVE FOR INDIVIDUAL PROTEIN VARIANTS 审中-公开纳米工艺用于生产蛋白对于个别选项选择性试剂
公开(公告)号：EP2831310A1
公开(公告)日：2015-02-04
申请号：EP13768129.2
申请日：2013-03-12
发明人： SIERKS, Michael , HAYES, Mark
CPC分类号： C07K14/4711 , B01L3/5027 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N27/447
摘要： The present invention provides devices and methods to separate and concentrate target protein species at a microliter scale and to generate reagents to those variants with exquisite selectivity for specific protein isoforms using only picograms of target material.
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公开(公告)号：EP2755942A2
公开(公告)日：2014-07-23
申请号：EP12772840.0
申请日：2012-09-13
IPC分类号： C07C57/50 , C07C57/62 , C07C59/48 , C07D213/55 , C07D239/28 , A61P25/28 , A61P35/00 , A61K31/192 , A61K31/435 , A61K31/4965
CPC分类号： A61K31/505 , C07C57/50 , C07C57/62 , C07C59/54 , C07C2602/10 , C07D213/55 , C07D213/80 , C07D239/28
摘要： The invention provides compounds of formula II: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.
摘要翻译： 本发明提供了式（I），（II），（III）和（IV）的化合物及其盐，以及包含这些化合物的药物组合物。 这些化合物可用于治疗癌症和阿尔茨海默病。
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公开(公告)号：EP2268489A1
公开(公告)日：2011-01-05
申请号：EP09729233.8
申请日：2009-03-25
IPC分类号： B32B43/00
CPC分类号： B32B43/006 , B32B38/0004 , B32B38/162 , B32B38/1875 , B32B2038/0044 , B32B2310/028 , B32B2457/202 , Y10T83/041 , Y10T83/0443 , Y10T83/242 , Y10T83/263 , Y10T83/293 , Y10T83/654 , Y10T83/8798 , Y10T156/1132 , Y10T156/1184 , Y10T156/1944 , Y10T156/1961 , Y10T156/1967
摘要： The present invention provides a debonding apparatus, a system comprising such apparatus, and methods for using such apparatus or system for the removal of flexible substrates (14) post-processing without damage to fabricated devices.
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公开(公告)号：EP2802602B1
公开(公告)日：2019-03-27
申请号：EP13700443.8
申请日：2013-01-10
发明人： SIERKS, Michael , SHEN, Yong
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公开(公告)号：EP2973209B1
公开(公告)日：2018-11-21
申请号：EP14779748.4
申请日：2014-03-12
发明人： KOZICKI, Michael N.
CPC分类号： G06K7/1099 , G02B21/06 , G02B21/365 , G02B27/286 , G06F17/3028 , G06F17/30879 , G06K9/00147 , G06K9/00577 , G06K9/2027 , G06K9/46 , G06K9/4671 , G06K9/6202 , G06K19/06046 , G06K19/07749 , G06K19/086 , G06T7/0012 , G06T7/12 , G06T2207/10056 , G06T2207/30024 , G09C5/00 , H04L9/3278 , H04L2209/12
摘要： The disclosure features dendritic tags, and methods and systems for fabricating and using such tags. The methods can include obtaining at least one image of a dendritic tag attached to an article, analyzing the at least one image to identify a set of features associated with the dendritic tag, and comparing the set of features to stored information to identify the article.
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