-
1.发明公开ORALLY ADMINISTRABLE PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRY EYE SYNDROME, COMPRISING REBAMIPIDE OR PRODRUG THEREOF 审中-公开可口服给药的药物组合物，瑞巴派特或任何IT前药的预防和治疗干眼病
公开(公告)号：EP2987491A4
公开(公告)日：2016-12-28
申请号：EP14785310
申请日：2014-04-17
申请人： SAMJIN PHARM CO LTD , ASTECH CO LTD
发明人： CHO EUI-HWAN , CHOI SUNG JU , LEE SUNG WOO , SHIN HEE JONG , YOON JONG BAE , PARK KI SEOK , NAM HO TAE
IPC分类号： A61K31/4704 , A61K9/00 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61P27/02
CPC分类号： A61K9/0053 , A61K31/4704 , A61K31/496 , A61K31/5377
摘要： Disclosed is an oral pharmaceutical composition for preventing or treating dry eye syndrome, which comprises rebamipide or a prodrug thereof, or a pharmaceutically acceptable salt thereof, as an active ingredient. The compounds can treat dry eye syndrome via oral route, and can be thus employed safely and conveniently compared to conventional eye drops.
摘要翻译： 公开了一种用于预防或治疗干眼症，其包含瑞巴派特或其前体药物，或其药学上可接受的盐，如活性成分的口服药物组合物。 所述化合物可通过口服途径治疗干眼综合征，并能安全，方便。因此采用比传统的眼药水。
-
公开(公告)号：EP2987491B1
公开(公告)日：2020-06-03
申请号：EP14785310.5
申请日：2014-04-17
发明人： CHO, Eui-Hwan , CHOI, Sung Ju , LEE, Sung Woo , SHIN, Hee Jong , YOON, Jong Bae , PARK, Ki Seok , NAM, Ho Tae
IPC分类号： A61K31/4704 , A61K31/5375 , A61P27/02 , A61K31/496 , A61K31/5377 , A61K9/00
-
3.发明公开NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF 审中-公开新型瑞巴派特的前体药物，方法用于其和使用其制造
公开(公告)号：EP2865669A4
公开(公告)日：2015-12-02
申请号：EP13809037
申请日：2013-06-26
申请人： SAMJIN PHARM CO LTD , ASTECH CO LTD
发明人： CHO EUI-HWAN , CHOI SUNG JU , LEE SUNG WOO , SHIN HEE JONG , KWON HO SEOK , LEE JAE WOONG , JOO JEONG HO , KIM HYUN TAE , SONG WOO HEON , YOON JONG BAE , PARK KI SEOK , PARK HO JOON , NAM HO TAE
IPC分类号： C07D215/227 , A61K31/4704 , A61P1/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D417/12 , A61K31/4704 , C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
-
4.发明公开ORALLY ADMINISTRABLE PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRY EYE SYNDROME, COMPRISING REBAMIPIDE OR PRODRUG THEREOF 审中-公开用于预防或治疗干眼症的口服药物组合物，包含利巴派酯或其制剂
公开(公告)号：EP2987491A1
公开(公告)日：2016-02-24
申请号：EP14785310.5
申请日：2014-04-17
发明人： CHO, Eui-Hwan , CHOI, Sung Ju , LEE, Sung Woo , SHIN, Hee Jong , YOON, Jong Bae , PARK, Ki Seok , NAM, Ho Tae
IPC分类号： A61K31/4704 , A61K31/5375 , A61P27/02
CPC分类号： A61K9/0053 , A61K31/4704 , A61K31/496 , A61K31/5377
摘要： Disclosed is an oral pharmaceutical composition for preventing or treating dry eye syndrome, which comprises rebamipide or a prodrug thereof, or a pharmaceutically acceptable salt thereof, as an active ingredient. The compounds can treat dry eye syndrome via oral route, and can be thus employed safely and conveniently compared to conventional eye drops.
摘要翻译： 公开了一种用于预防或治疗干眼症的口服药物组合物，其包含瑞巴派特或其前药或其药学上可接受的盐作为活性成分。 该化合物可以通过口服途径治疗干眼综合征，因此与传统滴眼液相比，可以安全且方便地使用该化合物。
-
5.发明公开
公开(公告)号：EP2865669A1
公开(公告)日：2015-04-29
申请号：EP13809037.8
申请日：2013-06-26
发明人： CHO, Eui-Hwan , CHOI, Sung Ju , LEE, Sung Woo , SHIN, Hee Jong , KWON, Ho Seok , LEE, Jae Woong , JOO, Jeong Ho , KIM, Hyun Tae , SONG, Woo Heon , YOON, Jong Bae , PARK, Ki Seok , PARK, Ho Joon , NAM, Ho Tae
IPC分类号： C07D215/227 , C07D413/12 , A61K31/4704 , A61P1/04
CPC分类号： C07D417/12 , A61K31/4704 , C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Disclosed are a novel rebamipide prodrug, a method for preparing the same, and use thereof. Also, a pharmaceutical composition comprising the novel rebamipide prodrug as an active ingredient is provided. The rebamipide prodrug is increased 25-fold in absorption rate compared to rebamipide itself, and can be applied to the prophylaxis or therapy of gastric ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, or obesity.
摘要翻译： 公开了一种新型瑞巴派特前药，其制备方法及其用途。 而且，提供了包含作为活性成分的新型瑞巴派特前药的药物组合物。 与瑞巴派特本身相比，瑞巴派特前药的吸收速率增加了25倍，并且可用于预防或治疗胃溃疡，急性胃炎，慢性胃炎，干眼症，癌症，骨关节炎，类风湿性关节炎或肥胖症。
-
6.发明公开SPHERICAL PARTICLES OF CLOPIDOGREL BISULFATE, PHARMACEUTICAL COMPOSITION INCLUDING SAME, AND METHOD FOR MANUFACTURING SAME 审中-公开FOR这样就产生硫酸氢氯吡格雷，药物组合物过程的球形颗粒
公开(公告)号：EP2732810A1
公开(公告)日：2014-05-21
申请号：EP11869405.8
申请日：2011-10-27
发明人： CHO, Eui Hwan , SHIN, Hee Jong , SONG, Woo Heon , LEE, Sun Hwan , YOON, Jong Bae , PARK, Jong Sung
IPC分类号： A61K9/16 , A61K9/20 , C07D495/04 , A61K31/4365
CPC分类号： A61K9/14 , A61K9/20 , A61K9/2018 , A61K9/2054 , A61K9/2095 , A61K31/4365 , C07D495/04 , Y10T428/2982
摘要： The present invention relates to spherical particles of clopidogrel bisulfate and a pharmaceutical composition containing the same. The inventive spherical particles can be used for preparing a tablet having sufficient hardness through direct compression, by improving unformulable properties of clopidogrel bisulfate such as compressibility, flowability and strong surface electrostatic charges, reduce a problem in compressing tablets such as weight variation, sticking, etc., and the risk of form conversion, and improve physiochemical stability. Therefore, the spherical particles of the present invention may be used as therapeutics for arteriosclerosis, stroke, myocardial infarction and atherosclerosis.
摘要翻译： 本发明涉及一种氯吡格雷硫酸氢盐和含有它们的药物组合物的球形颗粒。 本发明的球形颗粒可用于制备片剂具有通过直接压缩足够的硬度，通过提高硫酸氢氯吡格雷的unformulable属性：例如可压缩性，流动性和强的表面的静电荷，在压缩片剂减少了一个问题：如重量变化，粘着等 ，和晶型转化的风险，并提高生理化学稳定性。 因此，本发明的球形颗粒可以用作治疗动脉硬化，中风，心肌梗死和动脉粥样硬化。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.012 秒)
