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1.发明授权Amiloride analogues for use in a method of modulating ion channel functional activity and treating HIV infection 有权用于调节离子通道的功能活性的方法中使用和用于治疗HIV感染的阿米洛利类似物
公开(公告)号：EP1121128B1
公开(公告)日：2013-04-17
申请号：EP99970324.2
申请日：1999-10-12
申请人： Biotron Limited
发明人： COX, Graeme , EWART, Gary , GAGE, Peter
IPC分类号： A61K31/495 , A61K31/4965 , A61P31/18
CPC分类号： A61K31/4965 , A61K31/00
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公开(公告)号：EP4436576A1
公开(公告)日：2024-10-02
申请号：EP22896871.5
申请日：2022-11-24
申请人： Biotron Limited
IPC分类号： A61K31/415 , A61P31/14
CPC分类号： A61K31/415 , A61P31/14
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3.发明授权Hepatitis C antiviral compositions comprising 5-(1-methylpyrazol-4-yl)2-naphthoylguanidine and 2'-C-methyladenosine or 2'-C-methylcytidine 有权与5-（1-甲基吡唑-4-基）抗病毒丙型肝炎的组合物2-Naphthoylguanidine和2'-C-甲基腺苷或2'-C-甲基胞苷
公开(公告)号：EP2194976B1
公开(公告)日：2015-12-09
申请号：EP08782880.2
申请日：2008-08-04
申请人： Biotron Limited
IPC分类号： A61K31/155 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/435 , A61P31/14 , A61K31/7064 , A61K31/7068 , A61K45/06 , A61K31/7056 , A61K38/21
CPC分类号： C07C279/22 , A61K31/155 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/435 , A61K31/4418 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K38/212 , A61K45/06 , C07C311/08 , C07D213/69 , C07D231/12 , C07D307/54 , C07D333/24 , A61K2300/00
摘要： The present invention relates to novel compositions having anti-viral activity and in particular it relates to synergistic compositions active against Hepatitis C virus (HCV). The invention also relates to methods for retarding, reducing or otherwise inhibiting HCV growth and/or functional activity.
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公开(公告)号：EP1902017A1
公开(公告)日：2008-03-26
申请号：EP06741271.8
申请日：2006-06-23
申请人： Biotron Limited
IPC分类号： C07C279/22 , A61K31/415 , C07D231/12 , A61K31/155 , A61K31/435 , C07D307/54 , A61K31/341 , A61P31/12 , C07D317/60 , A61K31/36 , A61P31/18 , C07D333/24 , A61K31/381 , C07D213/69
CPC分类号： C07C279/22 , A61K31/155 , A61K31/381 , A61K31/415 , A61K31/4412 , A61K45/06 , C07D213/69 , C07D231/06 , C07D231/12 , C07D307/54 , C07D333/22 , Y02A50/385 , A61K2300/00
摘要： The present invention relates to novel compounds and compositions having antiviral activity. The invention also relates to methods for the therapeutic or prophylactic treatment of viral infections in mammals.
摘要翻译： 本发明涉及具有抗病毒活性的新化合物和组合物。 本发明还涉及用于哺乳动物中病毒感染的治疗或预防性治疗的方法。
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公开(公告)号：EP2659885B1
公开(公告)日：2016-11-09
申请号：EP13178966.1
申请日：2008-08-04
申请人： Biotron Limited
IPC分类号： A61K31/155 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/435 , A61P31/14 , A61K31/7064 , A61K31/7068 , A61K45/06 , A61K31/7056 , A61K38/21 , A61P1/16 , A61P31/12
CPC分类号： C07C279/22 , A61K31/155 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/435 , A61K31/4418 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K38/212 , A61K45/06 , C07C311/08 , C07D213/69 , C07D231/12 , C07D307/54 , C07D333/24 , A61K2300/00
摘要： The present invention relates to novel compositions having anti-viral activity and in particular it relates to synergistic compositions active against Hepatitis C virus (HCV). The invention also relates to methods for retarding, reducing or otherwise inhibiting HCV growth and/or functional activity.
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公开(公告)号：EP1646371A2
公开(公告)日：2006-04-19
申请号：EP04737487.1
申请日：2004-06-26
申请人： Biotron Limited
发明人： GAGE, Peter, William , EWART, Gary, Dinneen , WILSON, Lauren, Elizabeth , BEST, Wayne , PREMKUMAR, Anita
IPC分类号： A61K31/00
CPC分类号： C07D241/34 , A61K31/15 , A61K31/165 , A61K31/381 , A61K31/4406 , A61K31/47 , A61K31/4965 , A61K31/55 , A61K45/06 , C07C279/22
摘要： The invention relates to compounds having antiviral activity and methods utilising the compounds to treat viral infections.
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公开(公告)号：EP1425575A1
公开(公告)日：2004-06-09
申请号：EP02752896.7
申请日：2002-08-05
申请人： Biotron Limited
IPC分类号： G01N30/72 , G01N33/574 , G01N33/92
CPC分类号： G01N33/6848 , G01N30/7233 , G01N33/574 , G01N33/57484 , G01N33/57488 , G01N33/6851 , G01N2405/06
摘要： Provided are novel cancer markers for the diagnosis of cancer in humans and non-human mammalian subjects, specifically a cancer marker comprising a negatively-charged molecule with a mass/charge (m/z) ratio of about 991. The cancer marker of the invention may be used to determine the presence of one or more cancerous cells or tumors in a biological sample by assaying the sample for a reduced level of said cancer marker.
摘要翻译： 提供了用于诊断人类和非人类哺乳动物受试者中的癌症的新型癌症标志物，特别是包含具有约991的质量/电荷（m / z）比例的带负电荷的分子的癌症标志物。本发明的癌症标志物 可用于通过测定样品中降低水平的所述癌症标志物来确定生物样品中一种或多种癌细胞或肿瘤的存在。
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公开(公告)号：EP4065106A1
公开(公告)日：2022-10-05
申请号：EP20892907.5
申请日：2020-11-25
申请人： Biotron Limited
发明人： LUSCOMBE, Carolyn , EWART, Gary , MILLER, Michelle
IPC分类号： A61K31/415 , A61K31/536 , A61K31/675 , A61K31/513 , A61P31/18
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公开(公告)号：EP3579833A1
公开(公告)日：2019-12-18
申请号：EP18751710.7
申请日：2018-02-07
申请人： Biotron Limited
发明人： EWART, Gary , LUSCOMBE, Carolyn
IPC分类号： A61K31/415 , A61K31/155 , A61P31/16
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公开(公告)号：EP1902017B1
公开(公告)日：2014-03-26
申请号：EP06741271.8
申请日：2006-06-23
申请人： Biotron Limited
IPC分类号： C07C279/22 , A61K31/415 , C07D231/12 , A61K31/155 , A61K31/435 , C07D307/54 , A61K31/341 , A61P31/12 , C07D317/60 , A61K31/36 , A61P31/18 , C07D213/69 , C07D333/22
CPC分类号： C07C279/22 , A61K31/155 , A61K31/381 , A61K31/415 , A61K31/4412 , A61K45/06 , C07D213/69 , C07D231/06 , C07D231/12 , C07D307/54 , C07D333/22 , Y02A50/385 , A61K2300/00
摘要： The present invention relates to novel compounds and compositions having antiviral activity. The invention also relates to methods for the therapeutic or prophylactic treatment of viral infections in mammals.
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