公开(公告)号：EP2521917A4

公开(公告)日：2013-07-10

申请号：EP11732217

申请日：2011-01-07

Applicant: PHARMACO KINESIS CORP ,  WU WINSTON ,  CHEN THOMAS ,  FARKAS LESLIE ,  JORDAN BRETT ,  LUBOFF PALADIN ,  CHAN HERWIN ,  ZIMMERMAN KYLE ,  SHACHAR YEHOSHUA

Inventor： SHACHAR YEHOSHUA ,  WU WINSTON ,  CHEN THOMAS ,  FARKAS LESLIE ,  JORDAN BRETT ,  LUBOFF PALADIN ,  CHAN HERWIN ,  ZIMMERMAN KYLE

IPC: G01N33/53 ,  C12Q1/10 ,  G01N27/26 ,  G01N29/24 ,  G01N33/569 ,  G01N33/68

CPC classification number: G01N33/5308 ,  G01N33/5438 ,  G01N33/56916 ,  G01N2333/255

Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

Abstract translation: 一种基于适配子的固态电化学生物传感器，用于利用固定化适配子无标记检测肠道沙门氏菌血清型。 该器件通过形成并联电容器的矩阵阵列来实现，从而允许实现低成本，便携式，完全集成的器件。 蛋白质 - 适体结合调节电路的阈值电压，改变电路的阻抗（电容）。 该电路的特征还在于用p-Si底物编码的电极，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和力。 适配器嵌入的检测板配置在测试盖装置内，该装置适合标准的市售聚合物标本罐。 将样品与肉汤混合以培养和培养任何现有的沙门氏菌以获得可接受浓度的用于测试的病原体。 所获得的信息可以通过无线网络传输。

公开(公告)号：EP2521917A2

公开(公告)日：2012-11-14

申请号：EP11732217.2

申请日：2011-01-07

Applicant: Pharmaco-Kinesis Corporation ,  Wu, Winston ,  Chen, Thomas ,  Farkas, Leslie ,  Jordan, Brett ,  Luboff, Paladin ,  Chan, Herwin ,  Zimmerman, Kyle ,  Shachar, Yehoshua

Inventor： SHACHAR, Yehoshua ,  WU, Winston ,  CHEN, Thomas ,  FARKAS, Leslie ,  JORDAN, Brett ,  LUBOFF, Paladin ,  CHAN, Herwin ,  Zimmerman, Kyle

IPC: G01N33/53 ,  G01N33/68 ,  G01N27/26 ,  G01N33/569

CPC classification number: G01N33/5308 ,  G01N33/5438 ,  G01N33/56916 ,  G01N2333/255

Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

公开(公告)号：EP2561364A4

公开(公告)日：2013-09-04

申请号：EP11772655

申请日：2011-04-20

Applicant: PHARMACO KINESIS CORP ,  WU WINSTON ,  CHEN THOMAS ,  FARKAS LESLIE ,  JORDAN BRETT ,  LUBOFF PALADIN ,  CHAN HERWIN ,  ZIMMERMAN KYLE ,  SHACHAR YEHOSHUA

Inventor： SHACHAR YEHOSHUA ,  WU WINSTON ,  CHEN THOMAS ,  FARKAS LESLIE ,  JORDAN BRETT ,  LUBOFF PALADIN ,  CHAN HERWIN ,  ZIMMERMAN KYLE

IPC: G01N33/569 ,  C12N15/115 ,  C12Q1/04 ,  C12R1/42 ,  G01N27/26 ,  G01N33/543

CPC classification number: G01N33/5438 ,  G01N33/56916 ,  G01N2333/255

Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

Abstract translation: 一种基于适体的固态电化学生物传感器用于肠道沙门氏菌血清型的固定化利用适体的无标记检测。 该装置由形成并联电容器的矩阵阵列，从而允许实现低成本，便携，完全集成的装置的实现。 蛋白结合适体调制电路的阈值电压，改变电路的阻抗（电容）。 该电路是通过在电极与p Si衬底编码进一步的特征在于，增强了沙门氏菌外膜蛋白（OMP）和适体之间的亲和性。 适体嵌入式检测板被测试装置盖内配置的DID嵌合的标准，可商购的聚合物样品广口瓶中。 样品用肉汤对于任意出现的沙门氏菌的温育和栽培，以获得可接受的病原体进行检测的浓度混合。 该信息然后可以通过无线网络获得跨mitted。

公开(公告)号：EP2575615A2

公开(公告)日：2013-04-10

申请号：EP11787195.4

申请日：2011-05-23

Applicant: Shachar, Yehoshua ,  Chen, Thomas ,  Wu, Winston ,  Jordan, Brett ,  Chan, Herwin ,  Luboff, Paladin ,  Zimmerman, Kyle ,  Pharmaco-Kinesis Corporation

Inventor： SHACHAR, Yehoshua ,  CHEN, Thomas ,  WU, Winston ,  JORDAN, Brett ,  CHAN, Herwin ,  LUBOFF, Paladin ,  ZIMMERMANN, Kyle

IPC: A61B5/103 ,  A61B17/70 ,  A61B17/56 ,  A61B19/00 ,  A61F2/44

CPC classification number: A61B5/1114 ,  A61B5/413 ,  A61B5/45 ,  A61B5/6878 ,  A61B17/7074 ,  A61B2505/05 ,  A61B2560/0219 ,  A61B2562/043 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/4657

Abstract: A vertebral processor designed to collect and interpret data from multiple surgically implanted accelerometers. Each accelerometer is surgically implanted into a vertebra of a patient utilizing a bone screw. Additional accelerometers are implanted in adjacent vertebrae. The data from the accelerometers is compared by an algorithm to determine the relative movement of the accelerometers implanted in adjacent vertebrae. Data is generated via the algorithm and compared against the expected behavior of the surgically implanted accelerometers as if they were connected to a rigid body, thus determining the level of success of a spinal fusion procedure for those adjacent segments. The apparatus may be utilized with or without spinal stabilization hardware, and with or without fusion cages or artificial discs. The vertebral processor is supplemented by an external system worn by the patient, which provides for an inductive charging power source and for data transfer.

公开(公告)号：EP2561364B1

公开(公告)日：2017-07-12

申请号：EP11772655.4

申请日：2011-04-20

Applicant: Sensor-Kinesis Corporation ,  Wu, Winston ,  Chen, Thomas ,  Farkas, Leslie ,  Jordan, Brett ,  Luboff, Paladin ,  Chan, Herwin ,  Zimmerman, Kyle ,  Shachar, Yehoshua

Inventor： SHACHAR, Yehoshua ,  WU, Winston ,  CHEN, Thomas ,  FARKAS, Leslie ,  JORDAN, Brett ,  LUBOFF, Paladin ,  CHAN, Herwin ,  ZIMMERMAN, Kyle

IPC: G01N33/569 ,  G01N27/26 ,  C12Q1/04 ,  C12R1/42 ,  G01N33/543 ,  C12N15/115

CPC classification number: G01N33/5438 ,  G01N33/56916 ,  G01N2333/255

公开(公告)号：EP2490732B1

公开(公告)日：2015-06-17

申请号：EP10825505.0

申请日：2010-10-19

Applicant: Shachar, Yehoshua ,  Chen, Thomas ,  Farkas, Leslie ,  Jordan, Brett ,  Zimmerman, Kyle ,  Chan, Herwin ,  Pharmaco-Kinesis Corporation ,  Wu, Winston

Inventor： SHACHAR, Yehoshua ,  CHEN, Thomas ,  FARKAS, Leslie ,  JORDAN, Brett ,  ZIMMERMAN, Kyle ,  CHAN, Herwin ,  WU, Winston

IPC: A61M5/142 ,  A61F2/44 ,  A61B17/70 ,  A61M37/00 ,  A61M5/145 ,  A61F2/28 ,  A61F2/30

CPC classification number: A61M37/00 ,  A61F2/4465 ,  A61F2002/2817 ,  A61F2002/3067 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30841 ,  A61F2002/3092 ,  A61F2002/4475 ,  A61F2310/00023 ,  A61M5/14276 ,  A61M5/1452 ,  A61M2205/0294 ,  A61M2205/8243 ,  A61M2210/1003

公开(公告)号：EP2585818A4

公开(公告)日：2014-03-26

申请号：EP11798814

申请日：2011-06-22

Applicant: SHACHAR YEHOSHUA ,  CHEN THOMAS ,  WU WINSTON ,  JORDAN BRETT ,  CHAN HERWIN ,  LUBOFF PALADIN ,  ZIMMERMAN KYLE ,  PHARMACO KINESIS CORP

Inventor： SHACHAR YEHOSHUA ,  CHEN THOMAS ,  WU WINSTON ,  JORDAN BRETT ,  CHAN HERWIN ,  LUBOFF PALADIN ,  ZIMMERMAN KYLE

IPC: G01N27/327 ,  G01N27/26 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/74

CPC classification number: G01N33/48 ,  G01N33/5438 ,  G01N33/74 ,  G01N2333/475

公开(公告)号：EP2490732A4

公开(公告)日：2013-08-14

申请号：EP10825505

申请日：2010-10-19

Applicant: SHACHAR YEHOSHUA ,  CHEN THOMAS ,  FARKAS LESLIE ,  JORDAN BRETT ,  ZIMMERMAN KYLE ,  CHAN HERWIN ,  PHARMACO KINESIS CORP ,  WU WINSTON

Inventor： SHACHAR YEHOSHUA ,  CHEN THOMAS ,  FARKAS LESLIE ,  JORDAN BRETT ,  ZIMMERMAN KYLE ,  CHAN HERWIN ,  WU WINSTON

IPC: A61M5/142 ,  A61B17/70 ,  A61F2/28 ,  A61F2/30 ,  A61F2/44 ,  A61M5/145 ,  A61M37/00

CPC classification number: A61M37/00 ,  A61F2/4465 ,  A61F2002/2817 ,  A61F2002/3067 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30841 ,  A61F2002/3092 ,  A61F2002/4475 ,  A61F2310/00023 ,  A61M5/14276 ,  A61M5/1452 ,  A61M2205/0294 ,  A61M2205/8243 ,  A61M2210/1003

公开(公告)号：EP2585818A2

公开(公告)日：2013-05-01

申请号：EP11798814.7

申请日：2011-06-22

Applicant: Shachar, Yehoshua ,  Chen, Thomas ,  Wu, Winston ,  Jordan, Brett ,  Chan, Herwin ,  Luboff, Paladin ,  Zimmerman, Kyle ,  Pharmaco-Kinesis Corporation

Inventor： SHACHAR, Yehoshua ,  CHEN, Thomas ,  WU, Winston ,  JORDAN, Brett ,  CHAN, Herwin ,  LUBOFF, Paladin ,  ZIMMERMAN, Kyle

IPC: G01N27/327 ,  G01N33/50 ,  G01N33/53 ,  G01N27/26

CPC classification number: G01N33/48 ,  G01N33/5438 ,  G01N33/74 ,  G01N2333/475

Abstract: A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a
homeostatic
loop for chemotherapy.

公开(公告)号：EP2561364A2

公开(公告)日：2013-02-27

申请号：EP11772655.4

申请日：2011-04-20

Applicant: Pharmaco-Kinesis Corporation ,  Wu, Winston ,  Chen, Thomas ,  Farkas, Leslie ,  Jordan, Brett ,  Luboff, Paladin ,  Chan, Herwin ,  Zimmerman, Kyle ,  Shachar, Yehoshua

Inventor： SHACHAR, Yehoshua ,  WU, Winston ,  CHEN, Thomas ,  FARKAS, Leslie ,  JORDAN, Brett ,  LUBOFF, Paladin ,  CHAN, Herwin ,  ZIMMERMAN, Kyle

IPC: G01N33/569 ,  G01N27/26 ,  C12Q1/04 ,  C12R1/42

CPC classification number: G01N33/5438 ,  G01N33/56916 ,  G01N2333/255

Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.