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公开(公告)号：EP3625557A1
公开(公告)日：2020-03-25
申请号：EP18802717.1
申请日：2018-05-15
Applicant: Shachar, Yehoshua , Kornberg, Roger , Davis, Ralph , Sensor-Kinesis Corporation
Inventor： SHACHAR, Yehoshua , KORNBERG, Roger , DAVIS, Ralph
IPC: G01N29/02 , B82Y5/00 , B82Y15/00 , C12Q1/6809 , C12Q1/6825 , C12Q1/34 , H03H9/145
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2.发明授权METHOD AND APPARATUS FOR FORMING OF AN AUTOMATED SAMPLING DEVICE FOR THE DETECTION OF SALMONELLA ENTERICA UTILIZING AN ELECTROCHEMICAL APTAMER BIOSENSOR 有权用于利用电化学APTAMER生物检测器来检测沙门氏菌的自动采样装置的形成方法和设备
公开(公告)号：EP2561364B1
公开(公告)日：2017-07-12
申请号：EP11772655.4
申请日：2011-04-20
Applicant: Sensor-Kinesis Corporation , Wu, Winston , Chen, Thomas , Farkas, Leslie , Jordan, Brett , Luboff, Paladin , Chan, Herwin , Zimmerman, Kyle , Shachar, Yehoshua
Inventor： SHACHAR, Yehoshua , WU, Winston , CHEN, Thomas , FARKAS, Leslie , JORDAN, Brett , LUBOFF, Paladin , CHAN, Herwin , ZIMMERMAN, Kyle
IPC: G01N33/569 , G01N27/26 , C12Q1/04 , C12R1/42 , G01N33/543 , C12N15/115
CPC classification number: G01N33/5438 , G01N33/56916 , G01N2333/255
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3.发明授权
公开(公告)号：EP2490732B1
公开(公告)日：2015-06-17
申请号：EP10825505.0
申请日：2010-10-19
Applicant: Shachar, Yehoshua , Chen, Thomas , Farkas, Leslie , Jordan, Brett , Zimmerman, Kyle , Chan, Herwin , Pharmaco-Kinesis Corporation , Wu, Winston
Inventor： SHACHAR, Yehoshua , CHEN, Thomas , FARKAS, Leslie , JORDAN, Brett , ZIMMERMAN, Kyle , CHAN, Herwin , WU, Winston
CPC classification number: A61M37/00 , A61F2/4465 , A61F2002/2817 , A61F2002/3067 , A61F2002/30677 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/3092 , A61F2002/4475 , A61F2310/00023 , A61M5/14276 , A61M5/1452 , A61M2205/0294 , A61M2205/8243 , A61M2210/1003
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4.发明公开METHOD AND APPARATUS FOR MAGNETIC WAVEGUIDE FORMING A SHAPED FIELD EMPLOYING A MAGNETIC APERTURE FOR GUIDING AND CONTROLLING A MEDICAL DEVICE 审中-公开用磁性纤维SUCCESS端成型的方法和装置形领域具有磁性开幕，以保持和控制医疗设备的
公开(公告)号：EP2436098A4
公开(公告)日：2014-08-27
申请号：EP10781114
申请日：2010-05-26
Applicant: MAGNETECS INC , SHACHAR YEHOSHUA
Inventor： SHACHAR YEHOSHUA , FARKAS LASZLO , FARKAS LESLIE
CPC classification number: A61B1/00158 , A61B5/05 , A61B5/062 , A61B34/73 , A61B2034/731 , A61M25/0127
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5.发明公开ENHANCED METHOD FOR DELIVERING BEVACIZUMAB (AVASTIN) INTO A BRAIN TUMOR USING AN IMPLANTED MAGNETIC BREATHER PUMP 审中-公开先进的方法用于与植入的磁性排气泵IN脑癌贝伐单抗的递送（AVASTIN）
公开(公告)号：EP2490731A4
公开(公告)日：2013-11-20
申请号：EP10825493
申请日：2010-10-19
Applicant: SHACHAR YEHOSHUA , CHEN THOMAS , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LASZLO , PHARMACO KINESIS CORP
Inventor： SHACHAR YEHOSHUA , CHEN THOMAS , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LASZLO
CPC classification number: A61M5/14276 , A61K2039/54 , A61M5/14224 , A61M5/1723 , A61M2005/1726 , A61M2202/0464 , A61M2205/3507 , A61M2205/3523 , A61M2205/502 , A61M2210/0693 , C07K16/22
Abstract: A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
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Patent Agency Ranking6.发明公开METHOD AND APPARATUS FOR MAGNETIC WAVEGUIDE FORMING A SHAPED FIELD EMPLOYING A MAGNETIC APERTURE FOR GUIDING AND CONTROLLING A MEDICAL DEVICE 审中-公开用磁性纤维SUCCESS端成型的方法和装置形领域具有磁性开幕，以保持和控制医疗设备的
公开(公告)号：EP2436098A1
公开(公告)日：2012-04-04
申请号：EP10781114.3
申请日：2010-05-26
Applicant: MAGNETECS, INC , Shachar, Yehoshua
Inventor： SHACHAR, Yehoshua , FARKAS, Laszlo , FARKAS, Leslie
IPC: H02K1/00
CPC classification number: A61B1/00158 , A61B5/05 , A61B5/062 , A61B34/73 , A61B2034/731 , A61M25/0127
Abstract: A system that uses a magnetic aperture and electromagnets to configure a magnetic shaped field is described. In one embodiment, the system can be used for guiding a catheter or other devices through a patient's body. In further modification of the system, the waveguide field and field gradient is achieved by the use of varying the electromagnetic wave and its respective flux density axis. In one embodiment, one or more magnetic pole pieces (electromagnet cores) are configured with anisotropic permeability to control the shape of the resulting magnetic field. In one embodiment, the shape and permeability distribution in an electromagnet poleface is configured to produce the desired field distribution. In one embodiment, a number of electromagnets are arranged in a spherical pattern to produce a desired magnetic field in an enclosed spherical region.
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7.发明公开METRONOMIC CONVECTION ENHANCED DELIVERY OF INTRATHECAL CHEMOTHERAPY USING AN IMPLANTED MAGNETIC BREATHER PUMP (MBP) FOR LEPTOMENINGEAL CARCINOMATOSIS 审中-公开BY节律对流增强的管理鞘内化疗使用植入式磁排气泵（MBP）FOR脑膜癌病
公开(公告)号：EP2490745A4
公开(公告)日：2015-12-30
申请号：EP10825502
申请日：2010-10-19
Applicant: SHACHAR YEHOSHUA , CHEN THOMAS , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LASZLO , PHARMACO KINESIS CORP
Inventor： SHACHAR YEHOSHUA , CHEN THOMAS , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LASZLO
IPC: A61F2/958 , A61M25/10 , A61M1/00 , A61M5/14 , A61M5/142 , A61M5/172 , A61M25/088 , A61M25/092 , A61M31/00
CPC classification number: A61M5/14276 , A61M5/1408 , A61M5/14224 , A61M5/148 , A61M5/1723 , A61M2005/14292 , A61M2005/14296 , A61M2005/1726 , A61M2202/0464 , A61M2202/049 , A61M2205/3523 , A61M2205/3569 , A61M2205/8243 , A61M2209/01 , A61M2210/0693 , A61M2230/005
Abstract: A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
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8.发明公开
公开(公告)号：EP2536329A4
公开(公告)日：2015-09-09
申请号：EP11745143
申请日：2011-02-16
Applicant: SHACHAR YEHOSHUA , MARX BRUCE , FARKAS LESLIE , GANG ELI , FARKAS LASZLO , MAGNETECS INC
Inventor： SHACHAR YEHOSHUA , MARX BRUCE , FARKAS LESLIE , GANG ELI , FARKAS LASZLO
IPC: A61B5/042 , A61B5/00 , A61B5/0402 , A61B5/0436 , A61B5/044 , A61B5/053 , A61B5/06 , A61B5/107
CPC classification number: A61B5/0538 , A61B5/0402 , A61B5/06 , A61B5/062 , A61B5/1075 , A61B5/6851 , A61B5/6852 , A61B5/6869 , A61B5/6885
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9.发明公开METHOD AND APPARATUS FOR FORMING OF AN AUTOMATED SAMPLING DEVICE FOR THE DETECTION OF SALMONELLA ENTERICA UTILIZING AN ELECTROCHEMICAL APTAMER BIOSENSOR 审中-公开方法和设备形成自动取样装置技术沙门氏菌的检测Microchip电化学APTAMERBIOSENSORS
公开(公告)号：EP2521917A2
公开(公告)日：2012-11-14
申请号：EP11732217.2
申请日：2011-01-07
Applicant: Pharmaco-Kinesis Corporation , Wu, Winston , Chen, Thomas , Farkas, Leslie , Jordan, Brett , Luboff, Paladin , Chan, Herwin , Zimmerman, Kyle , Shachar, Yehoshua
Inventor： SHACHAR, Yehoshua , WU, Winston , CHEN, Thomas , FARKAS, Leslie , JORDAN, Brett , LUBOFF, Paladin , CHAN, Herwin , Zimmerman, Kyle
IPC: G01N33/53 , G01N33/68 , G01N27/26 , G01N33/569
CPC classification number: G01N33/5308 , G01N33/5438 , G01N33/56916 , G01N2333/255
Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.
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10.发明授权METHOD AND APPARATUS FOR FORMING A HOMEOSTATIC LOOP EMPLOYING AN APTAMER BIOSENSOR 有权方法和设备形成稳态，循环从适体生物传感器
公开(公告)号：EP2417440B1
公开(公告)日：2016-12-07
申请号：EP10762472.8
申请日：2010-04-09
Applicant: Pharmaco-Kinesis Corporation , Shachar, Yehoshua , Wu, Winston , Farkas, Leslie , Chen, Thomas
Inventor： SHACHAR, Yehoshua , WU, Winston , FARKAS, Leslie , CHEN, Thomas
IPC: G01N27/26 , G01N27/403 , G01N27/327 , G01N33/53 , G01N27/00 , G01N33/542 , G01N33/543
CPC classification number: G01N33/54373 , G01N33/542
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