公开(公告)号：EP3474822A1

公开(公告)日：2019-05-01

申请号：EP17737695.1

申请日：2017-06-28

申请人： Chimerix, Inc.

发明人： WARE, Roy Wendell ,  KABIR, Mohammed Anowrul ,  NADERER, Odin Johann ,  GROSSI, Irma Marisa

IPC分类号： A61K9/08 ,  A61K9/19 ,  A61K47/18 ,  A61K47/26 ,  A61K31/685

公开(公告)号：EP2999476B1

公开(公告)日：2018-08-08

申请号：EP14861700.4

申请日：2014-10-10

申请人： Chimerix, Inc.

发明人： WARE, Roy Wendell ,  DOWNEY, Aaron Leigh

IPC分类号： A61K31/675 ,  C07F9/6512 ,  C07D239/47

CPC分类号： C07D239/47 ,  C07F9/53 ,  C07F9/6512

摘要： The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

公开(公告)号：EP2534150B1

公开(公告)日：2017-04-05

申请号：EP11742971.2

申请日：2011-02-14

申请人： Chimerix, Inc.

发明人： ALMOND, Merrick ,  LAMPERT, Bernhard ,  LANIER, Ernest, Randall ,  WARE, Roy

IPC分类号： C07D473/34 ,  A61K45/06 ,  A61K31/52 ,  A61P31/12

CPC分类号： C07F9/65616 ,  A61K31/52 ,  A61K45/06 ,  C07D473/34 ,  A61K2300/00

公开(公告)号：EP3085377A1

公开(公告)日：2016-10-26

申请号：EP16151475.7

申请日：2009-01-23

申请人： Chimerix, Inc.

发明人： LANIER, Ernest Randall ,  ALMOND, Merrick R. ,  PAINTER, George R.

IPC分类号： A61K31/706 ,  A61K31/675 ,  A61K9/00 ,  A61P31/14 ,  A61P31/18

CPC分类号： A61K31/675 ,  A61K9/0014 ,  A61K31/706 ,  A61K2300/00 ,  Y02A50/411

摘要： The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective treat the HIV and/or HBV infection and at least substantially inhibit the development of resistance to said antiviral compounds in the subject. Pharmaceutical compositions are also provided.

摘要翻译： 本发明提供了治疗人类免疫缺陷病毒（HIV）和/或乙型肝炎病毒（HBV）感染的方法，包括以有效治疗HIV和/或HBV感染的量施用本发明中描述的化合物，并至少基本上抑制 发展对受试者中所述抗病毒化合物的抗性。 还提供药物组合物。

公开(公告)号：EP2462152A4

公开(公告)日：2013-02-13

申请号：EP10806986

申请日：2010-08-02

申请人： CHIMERIX INC

发明人： LANIER ERNEST R ,  PAINTER GEORGE R

IPC分类号： C07F9/6512 ,  C07F9/6558 ,  C07F9/6561 ,  C07F9/6571

CPC分类号： C07F9/65121 ,  C07F9/65586 ,  C07F9/65616 ,  C07F9/657181

公开(公告)号：EP1865967A2

公开(公告)日：2007-12-19

申请号：EP06749663.8

申请日：2006-04-10

申请人： Chimerix, Inc.

发明人： ALMOND, Merrick, R. ,  PAINTER, George, R.

IPC分类号： A61K31/675

CPC分类号： A61K31/675 ,  A61K47/543 ,  A61K47/544 ,  A61K2300/00

摘要： The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes.

公开(公告)号：EP0350287B1

公开(公告)日：2000-09-27

申请号：EP89306815.5

申请日：1989-07-05

申请人： Chimerix, Inc.

发明人： Hostetler, Karl Y. ,  Kumar, Raj ,  Stuhmiller, Louise M.

IPC分类号： C07H19/073 ,  C07F9/6558 ,  C07F9/6561 ,  C07H19/173 ,  A61K9/127 ,  A61K31/70

CPC分类号： C07H15/04 ,  A01N43/40 ,  A61K9/127 ,  A61K47/542 ,  A61K47/544 ,  A61K47/548 ,  C07C17/093 ,  C07C25/13 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07H19/04 ,  C07H19/06 ,  C07H19/16

公开(公告)号：EP3020720A1

公开(公告)日：2016-05-18

申请号：EP15193479.1

申请日：2011-08-31

申请人： Chimerix, Inc.

发明人： WARE, Roy ,  ALMOND, Merrick ,  LAMPERT, Bernhard

IPC分类号： C07F9/38 ,  C07F9/40 ,  A61K31/675 ,  A61K47/48 ,  A61P31/12 ,  C07F9/6571 ,  C07F9/6512

CPC分类号： C07F9/4021 ,  A61K31/675 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/6512 ,  C07F9/657181 ,  Y02A50/467 ,  Y02P20/55

摘要： The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

摘要翻译： 本公开描述了膦酸酯衍生物的合成方法。 根据本公开的优选方法允许大规模制备具有高纯度的膦酸酯化合物。 在一些实施方案中，根据本公开内容的优选方法还允许制备膦酸酯衍生物而不使用色谱纯化方法并且以比先前使用的制备此类化合物的方法更好的收率。 还公开了膦酸酯衍生物的变体形式。

公开(公告)号：EP2841162A4

公开(公告)日：2016-02-24

申请号：EP13781493

申请日：2013-04-26

申请人： CHIMERIX INC

发明人： PAINTER GEORGE R ,  LANIER ERNEST RANDALL ,  MARGOLSKEE DOROTHY ,  PAINTER GWENDOLYN POWELL ,  WARE ROY

IPC分类号： A61P31/20 ,  A61K31/662

CPC分类号： A61K31/675 ,  A61K9/2027 ,  A61K31/522 ,  A61K31/662 ,  A61K2300/00

摘要： The present application provides methods and compositions for treatment or reducing risk of dsDNA virus infection in post-hematopoietic cell transplant (HCT or HSCT) patients. This application also provides methods and composition for reducing the incidence of BK virus associated hematuria and/or renal impairment. The invention also relates to a method of lowering BK viral load in post-hematopoietic cell transplant (HCT or HSCT) patients with HDP-CDV (HDP-CDV) or compound of Formula II, or a pharmaceutically acceptable salt thereof, thereby delaying onset of or reducing risk of end organ disease in these patients.

公开(公告)号：EP2842559A3

公开(公告)日：2015-03-18

申请号：EP14185444.8

申请日：2006-04-10

申请人： Chimerix, Inc.

发明人： Almond, Merrick R. ,  Painter, George R

IPC分类号： A61K31/675 ,  A61K47/48 ,  A61P31/12

CPC分类号： A61K31/675 ,  A61K47/543 ,  A61K47/544 ,  A61K2300/00

摘要： The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes.