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1.发明公开Corticospinal upper motor neurons, methods and compositions for differentiating neural stem cells by modulating CB1 cannabinoid receptor signaling and uses thereof 有权由CB1大麻素受体信号传导的调节上金字塔运动神经元，方法和组合物用于神经干细胞的分化及其用途
公开(公告)号：EP2733205A1
公开(公告)日：2014-05-21
申请号：EP12382455.9
申请日：2012-11-20
申请人： Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned , Universidad Complutense De Madrid
IPC分类号： C12N5/079 , C07D487/00 , A61K31/352 , A61K31/4355 , C07D401/12
CPC分类号： C12N5/0619 , A61K31/343 , A61K31/352 , A61K31/4439 , A61K35/30 , C12N2501/80
摘要： The present invention relates to compositions and methods for obtaining a corticospinal upper motor neuron from a neural stem cell comprising the use of a CB 1 cannabinoid receptor agonist, or the use of an inhibitor of an endocannabinoid-degrading enzyme, or the modification of a neural stem cell to decrease the expression of an endocannabinoid-degrading enzyme under basal levels or to increase the expression of the CB 1 cannabinoid receptor above basal levels. The invention also relates to the corticospinal upper motor neurons obtained and uses thereof.
摘要翻译： 本发明涉及组合物和方法，用于从神经干细胞，其包含使用CB 1种大麻素受体激动剂的，或使用内源性大麻素降解酶的抑制剂，或神经的修改获得一个皮质上运动神经元 干细胞以降低内源性大麻素降解酶的表达下基础水平或增加基础水平以上的CB1大麻素受体的表达。 因此，本发明涉及获得皮质上运动神经元和其用途。
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公开(公告)号：EP3713568A1
公开(公告)日：2020-09-30
申请号：EP18796407.7
申请日：2018-10-26
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Universidad Autónoma de Madrid , Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned , BlumenTech S.L. , Institut Recerca Hospital de la Santa Creu I Sant Pau
IPC分类号： A61K31/4045 , A61K45/06 , A61P25/00
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公开(公告)号：EP2733205B1
公开(公告)日：2018-01-10
申请号：EP12382455
申请日：2012-11-20
申请人： CENTRO DE INVESTIGACÍON BIOMÉDICA EN RED DE ENFERMEDADES NEURODEGENERATIVAS CIBERNED , UNIV MADRID COMPLUTENSE
发明人： GALVE-ROPERH ISMAEL , GUZMÁN PASTOR MANUEL , DÍAZ-ALONSO JAVIER , AGUADO SANCHEZ TANIA , PARAÍSO LUNA JUAN
IPC分类号： A61K31/4439 , A61K31/343 , A61K31/352 , A61K35/30 , C12N5/0793
CPC分类号： C12N5/0619 , A61K31/343 , A61K31/352 , A61K31/4439 , A61K35/30 , C12N2501/80
摘要： The present invention relates to compositions and methods for obtaining a corticospinal upper motor neuron from a neural stem cell comprising the use of a CB 1 cannabinoid receptor agonist, or the use of an inhibitor of an endocannabinoid-degrading enzyme, or the modification of a neural stem cell to decrease the expression of an endocannabinoid-degrading enzyme under basal levels or to increase the expression of the CB 1 cannabinoid receptor above basal levels. The invention also relates to the corticospinal upper motor neurons obtained and uses thereof.
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公开(公告)号：EP3163303A1
公开(公告)日：2017-05-03
申请号：EP15382537
申请日：2015-11-02
申请人： BIOCROSS S L , INST DE SALUD CARLOS III , CENTRO DE INVESTIGACÍON BIOMÉDICA EN RED DE ENFERMEDADES NEURODEGENERATIVAS CIBERNED
CPC分类号： G01N33/6896 , G01N33/54393 , G01N33/92 , G01N2333/775 , G01N2800/2814 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835
摘要： The present invention relates to methods for the detection and quantification of apolipoproteins and isoforms thereof in a sample, as well as to predictive methods of the probability of neurodegenerative or cardiovascular disease development based on apolipoprotein levels as determined by the detection methods of the invention.
摘要翻译： 本发明涉及用于检测和定量样品中载脂蛋白及其同种型的方法，以及根据本发明的检测方法确定的基于载脂蛋白水平的神经变性或心血管疾病发展概率的预测方法。
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公开(公告)号：EP3274725B1
公开(公告)日：2019-01-09
申请号：EP16794966.8
申请日：2016-11-02
申请人： Biocross, S.L. , Instituto de Salud Carlos III , Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned
IPC分类号： G01N33/92 , G01N33/543 , G01N33/68
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6.发明公开CORTICOSPINAL UPPER MOTOR NEURONS, METHODS AND COMPOSITIONS FOR DIFFERENTIATING NEURAL STEM CELLS BY MODULATING CB1 CANNABINOID RECEPTOR SIGNALING AND USES THEREOF 审中-公开通过调节CB1大麻素受体信号转导来分化神经干细胞的皮质上皮运动神经元，方法和组合物及其用途
公开(公告)号：EP3279316A1
公开(公告)日：2018-02-07
申请号：EP17192973.0
申请日：2012-11-20
申请人： Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned , Universidad Complutense de Madrid
发明人： GALVE-ROPERH, Ismael , GUZMÁN PASTOR, Manuel , DÍAZ-ALONSO, Javier , AGUADO SANCHEZ, Tania , PARAÍSO LUNA, Juan
IPC分类号： C12N5/079 , C07D487/00 , A61K31/352 , A61K31/4355 , C07D401/12 , A61K31/343 , A61K35/30 , C12N5/0793 , A61K31/4439
CPC分类号： C12N5/0619 , A61K31/343 , A61K31/352 , A61K31/4439 , A61K35/30 , C12N2501/80
摘要： The present invention relates to compositions and methods for obtaining a corticospinal upper motor neuron from a neural stem cell comprising the use of a CB 1 cannabinoid receptor agonist, or the use of an inhibitor of an endocannabinoid-degrading enzyme, or the modification of a neural stem cell to decrease the expression of an endocannabinoid-degrading enzyme under basal levels or to increase the expression of the CB 1 cannabinoid receptor above basal levels. The invention also relates to the corticospinal upper motor neurons obtained and uses thereof.
摘要翻译： 本发明涉及用于从神经干细胞获得皮质脊髓上运动神经元的组合物和方法，其包括使用CB1大麻素受体激动剂或使用内源性大麻素降解酶抑制剂或修饰神经干 细胞在基础水平下降低内源性大麻素降解酶的表达或增加CB1大麻素受体高于基础水平的表达。 本发明还涉及获得的皮质脊髓上运动神经元及其应用。
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公开(公告)号：EP3457140A1
公开(公告)日：2019-03-20
申请号：EP18201037.1
申请日：2016-11-02
申请人： Biocross, S.L. , Instituto de Salud Carlos III , Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned
IPC分类号： G01N33/68 , G01N33/92 , G01N33/543
摘要： The present invention relates to methods for the detection and quantification of apolipoproteins and isoforms thereof in a sample, as well as to predictive methods of the probability of neurodegenerative or cardiovascular disease development based on apolipoprotein levels as determined by the detection methods of the invention.
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公开(公告)号：EP3274725A2
公开(公告)日：2018-01-31
申请号：EP16794966.8
申请日：2016-11-02
申请人： Biocross, S.L. , Instituto de Salud Carlos III , Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned
IPC分类号： G01N33/92 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/54393 , G01N33/6842 , G01N33/6893 , G01N33/92 , G01N2333/775 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835 , G01N2800/32 , G01N2800/50
摘要： The present invention relates to methods for the detection and quantification of apolipoproteins and isoforms thereof in a sample, as well as to predictive methods of the probability of neurodegenerative or cardiovascular disease development based on apolipoprotein levels as determined by the detection methods of the invention.
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9.发明公开METHOD FOR THE DIAGNOSIS AND/OR PROGNOSIS OF NEURODEGENERATIVE DISEASES 审中-公开VERFAHREN ZUR DIAGNOSE UND / ODER PROGNOSE VON NEURODEGENERATIVEN ERKRANKUNGEN
公开(公告)号：EP2924124A1
公开(公告)日：2015-09-30
申请号：EP13856389.5
申请日：2013-10-17
申请人： Consejo Superior De Investigaciones Científicas (CSIC) , Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： The invention relates to the use of mitochondrial DNA as a quantitative biomarker of neurodegenerative diseases, preferably of Alzheimer disease. The invention also relates to a method and to a kit for the diagnosis and/or prognosis of said diseases using said biomarker.
摘要翻译： 本发明涉及线粒体DNA作为神经变性疾病，优选阿尔茨海默病的定量生物标志物的用途。 本发明还涉及使用所述生物标志物诊断和/或预测所述疾病的方法和试剂盒。
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