公开(公告)号：EP4386008A1

公开(公告)日：2024-06-19

申请号：EP22855400.2

申请日：2022-08-08

申请人： Changchun Intellicrown Pharmaceutical Co., Ltd. ,  Shanghai Intellicrown Biotechnology Co., Ltd.

发明人： ZHANG, Xin ,  SONG, Gongming ,  JIA, Wei ,  ZHANG, Xitian

IPC分类号： C07K19/00 ,  A61K38/16 ,  A61P35/00

CPC分类号： A61P35/00 ,  A61K38/16 ,  C07K19/00 ,  C12N15/63 ,  C07K14/375 ,  C07K2319/0020130101 ,  C07K2319/0220130101 ,  C12R2001/64520210501

摘要： The present application relates to a recombinant protein comprising a spacer peptide and a recombinant Ganoderma lucidum immunomodulatory protein mutant (rLZ-8 mutant), wherein an amino acid sequence of the rLZ-8 mutant comprises at least one amino acid mutation as compared with an amino acid sequence as shown in SEQ ID NO: 10. The present application further relates to use of the recombinant protein for treating diseases.

公开(公告)号：EP4050004A1

公开(公告)日：2022-08-31

申请号：EP20892802.8

申请日：2020-09-15

申请人： INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES ,  Changchun Intellicrown Pharmaceutical Co., Ltd.

发明人： WU, Song ,  SUN, Hua ,  ZHANG, Jinlan ,  ZHANG, Wenxuan ,  WANG, Zhe ,  YANG, Qingyun ,  JIANG, Lin ,  CHEN, Zihan ,  SHEN, Jing ,  ZHANG, Jie ,  ZHANG, Chi ,  HAN, Zunsheng ,  QIN, Tong ,  ZHANG, Yuanyuan

IPC分类号： C07D317/68 ,  A61K31/5377 ,  A61P1/16 ,  A61P31/14 ,  A61P31/20 ,  A61P37/02

摘要： The invention relates to the field of pharmaceutical chemistry, and it particularly relates to a left-handed bicyclic morpholine and a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and use thereof in the preparation of medicaments for preventing and/or treating liver diseases and the like.