公开(公告)号：EP2776086B1

公开(公告)日：2018-12-26

申请号：EP12847108.3

申请日：2012-11-07

申请人： Delcath Systems, Inc.

发明人： JOHNSTON, Daniel, S. ,  CHAMMAS, Jacques ,  APPLING, William M. ,  BARTON, Samantha

IPC分类号： A61M1/34 ,  A61M1/36 ,  B01J20/28 ,  B01J20/20 ,  B01J20/26 ,  B01J20/30 ,  B01J20/32 ,  C01B32/354 ,  C01B32/372

CPC分类号： A61M1/34 ,  A61M1/3406 ,  A61M1/3615 ,  A61M1/3687 ,  A61M2205/3306 ,  A61M2205/50 ,  B01J20/20 ,  B01J20/261 ,  B01J20/28011 ,  B01J20/28066 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/3078 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3293 ,  C01B32/354 ,  C01B32/372

摘要： A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

公开(公告)号：EP1940463A2

公开(公告)日：2008-07-09

申请号：EP06825089.3

申请日：2006-09-22

申请人： Cytologic, Inc.

发明人： HOWELL, Mark Douglas

IPC分类号： A61K39/385 ,  A61K38/19

CPC分类号： A61M1/3621 ,  A61K38/00 ,  A61M1/3615 ,  A61M1/38 ,  C07K14/525

摘要： Provided is a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partners such as TNF&agr; muteins capable of binding to and, thus, depleting the targeted immune system inhibitors from the biological fluids. Particularly useful is an adsorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNF&agr; mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor.

摘要翻译： 本发明提供了增强哺乳动物免疫应答以促进消除慢性病理学的方法。 该方法涉及从哺乳动物的循环中除去免疫系统抑制剂如可溶性TNF受体，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除是通过使哺乳动物的生物流体与一种或多种结合配偶体（例如TNFα突变蛋白）结合并从而从生物流体中消除靶向的免疫系统抑制剂而实现的。 在本发明中特别有用的是一种吸收性基质，其由与能够特异性结合靶向免疫系统抑制剂例如可溶性TNF受体的结合配偶体诸如TNFα突变蛋白共价连接的惰性生物相容底物组成。

公开(公告)号：EP1119389B1

公开(公告)日：2005-12-28

申请号：EP99953060.3

申请日：1999-10-05

申请人： Corgentech, Inc.

发明人： Mann, Michael J.

IPC分类号： A61M31/00

CPC分类号： A61M1/3687 ,  A61B90/39 ,  A61B2090/3954 ,  A61M1/3615 ,  A61M2025/0057

摘要： The invention relates to use of pulmonary catheters in methods for delivering a composition to the lung in a non-surgical, percutaneous approach by utilizing the pulmonary vasculature (i.e., the pulmonary arteries and veins). The invention also relates to methods allowing for the lung-specific delivery of a composition, as well as a catheter that includes a deployable arm.

公开(公告)号：EP1032453A1

公开(公告)日：2000-09-06

申请号：EP98944574.7

申请日：1998-08-26

申请人： Delcath Systems, Inc.

发明人： GLICKMAN, Morton, G.

IPC分类号： A61M31/00

CPC分类号： A61M25/1011 ,  A61M1/1698 ,  A61M1/3615

摘要： An apparatus, a kit and a method for treating a tumor in an extremity of a patient. The method first includes: providing a first catheter (9) designed, sized and dimensioned for percutaneous insertion into the specific vein or portion of vein of the extremity receiving the blood from the tumor, including a plastic tube having a cranial end and a caudale end. The plastic tube defines a main lumen for outflow blood, two balloons (11, 12) spaced apart about the plastic tube and bonded thereto for inflation thereabout. One balloon is contiguous to the cranial end wherein the balloons (11, 12) are sized and spaced on the plastic tube sufficient that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in the vein and to substantially isolate outflow from the tumor to other portions of the vein; fenestration (104) in the plastic tube between the balloons (11, 12) to the main lumen; second, and third lumina within the plastic tube. The second lumen connects to one of the balloons, the third lumen connects to the other of the balloons for effecting inflation or deflation of the balloons; the cranial end of the plastic tube being closed to substantially all inflow of blood.

摘要翻译： 一种用于治疗患者肢体中的肿瘤的设备，试剂盒和方法。 该方法首先包括：提供第一导管（9），其被设计，确定尺寸和尺寸以用于经皮插入到从肿瘤接收血液的肢体的特定静脉或部分静脉中，包括具有头端和尾端的塑料管 。 塑料管限定了用于流出血液的主腔，两个在塑料管周围间隔开并结合在其上以便在其周围充气的气球（11,12）。 一个球囊邻接颅端，其中球囊（11,12）的尺寸和间隔设置在塑料管上，足以在充气时它们之间具有足够的尺寸和间距以基本上阻塞静脉中血液的流动并基本上隔离 从肿瘤流出到静脉的其他部分; 在球囊（11,12）与主腔之间的塑料管中开窗（104） 第二个和第三个腔室在塑料管内。 第二管腔连接到一个气球，第三管腔连接到另一个气球，以实现气球的充气或放气; 塑料管的头端几乎全部流入血液。

公开(公告)号：EP2531251A4

公开(公告)日：2016-03-02

申请号：EP11740297

申请日：2011-02-02

申请人： NIRVA MEDICAL LLC

发明人： HOCHAREON PRAMOTE

IPC分类号： A61M25/10 ,  A61M1/36

CPC分类号： A61M25/007 ,  A61M1/36 ,  A61M1/3604 ,  A61M1/3613 ,  A61M1/3615 ,  A61M1/3666 ,  A61M1/369 ,  A61M5/142 ,  A61M25/0071 ,  A61M25/04 ,  A61M25/10 ,  A61M2025/0004 ,  A61M2025/0031 ,  A61M2025/0037 ,  A61M2025/1052 ,  A61M2025/1095 ,  A61M2205/36

摘要： A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.

公开(公告)号：EP2819736A1

公开(公告)日：2015-01-07

申请号：EP13707005.8

申请日：2013-03-01

申请人： Medical Device Works NV

发明人： FIERENS, Joop ,  NACKARD, Kevin Jason ,  MARCOUX, Eric Thierry Jean ,  BARTHOLOME, Emmanuel J.

IPC分类号： A61M25/00

CPC分类号： A61M1/34 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00893 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61M1/32 ,  A61M1/3455 ,  A61M1/3615 ,  A61M1/3621 ,  A61M1/367 ,  A61M5/142 ,  A61M25/007 ,  A61M25/0074 ,  A61M25/0075 ,  A61M25/10 ,  A61M25/1018 ,  A61M25/10183 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2205/3303 ,  A61M2205/3344 ,  A61N5/1002

摘要： The present application provides a device for the simultaneous or the separate perfusion and occlusion of a vessel comprising a body having a distal end, a proximal end, a single lumen (66, 80) extending between the proximal end and the distal end, and at least one opening (63,72) which is in fluid communication with the lumen for delivering a therapeutic treatment to a vessel; and at least one expandable balloon (65,70,81) coupled with the body of the device, said balloon is provided with an interior which is in fluid communication with the lumen of the device through at least one opening (68, 69, 70), said opening is provided with at least one valve (71) which is movable from a closed position, in which fluid communication of the lumen with the interior of the balloon is prevented, to an open position in which the lumen is in fluid communication with the interior of the balloon.

摘要翻译： 本申请提供了用于同时或分开灌注和闭塞血管的装置，该装置包括具有远端，近端，在近端和远端之间延伸的单个内腔（66,80）的主体，以及在 至少一个开口（63,72），其与所述腔流体连通以将治疗处理输送至血管; 和至少一个与所述装置的主体连接的可扩张球囊（65,70,81），所述球囊设置有内部，所述内部通过至少一个开口（68,69,70）与所述装置的内腔流体连通， ），所述开口设置有至少一个阀（71），所述至少一个阀（71）能够从关闭位置移动到关闭位置，在所述关闭位置，所述内腔与所述气囊的内部的流体连通被阻止到所述内腔流体连通的打开位置 与气球的内部。

公开(公告)号：EP1967222A3

公开(公告)日：2010-02-24

申请号：EP08009230.7

申请日：2000-01-13

申请人： Rand S.r.l.

发明人： Benatti, Luigi

IPC分类号： A61M1/36 ,  A61M5/142

CPC分类号： A61M1/3621 ,  A61M1/1698 ,  A61M1/28 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3451 ,  A61M1/3613 ,  A61M1/3615 ,  A61M2205/3331 ,  A61M2209/082

摘要： The multipurpose machine for monitoring an control of therapies comprises a head (2) which has a box-like structure, a base (3) to support said head (2) and modifying means (4) for modifying its dimensions.

摘要翻译： 用于监测和控制肿瘤学局部治疗的多用途机器包括具有盒状结构的头部（2），由设置有用于修改其尺寸的手推车（8）的基座（3）支撑，并且具有 吸附剂和/或过滤装置（6）和用于控制和调节沿着容纳在头部（2）中的第一组管道（104）的电路布置的化学和化学过滤的对照（7）。 第一组电路（104）被分成至少两个环（104a，104b），每个环具有其自己的泵（105,106）; 循环是相互交互的或可分离的，并且提供第一循环（104a）用于输注化学治疗剂（C），并且提供第二环（104b）用于化学治疗剂的过滤; 为了检测泵（105,106）的故障并在功能上恢复至少输液回路（104a），紧急电子电路（109）插入在两个回路（104a，104b）之间。 头部（2）还容纳第二主要电路组（110），其可相对于第一主电路（104）交替激活，并且意在进行腹膜内超热灌注治疗。

公开(公告)号：EP1119389A1

公开(公告)日：2001-08-01

申请号：EP99953060.3

申请日：1999-10-05

申请人： Mann, Michael J.

发明人： Mann, Michael J.

IPC分类号： A61M31/00

CPC分类号： A61M1/3687 ,  A61B90/39 ,  A61B2090/3954 ,  A61M1/3615 ,  A61M2025/0057

摘要： The invention relates to use of pulmonary catheters in methods for delivering a composition to the lung in a non-surgical, percutaneous approach by utilizing the pulmonary vasculature (i.e., the pulmonary arteries and veins). The invention also relates to methods allowing for the lung-specific delivery of a composition, as well as a catheter that includes a deployable arm.

公开(公告)号：EP1032453A4

公开(公告)日：2000-11-02

申请号：EP98944574

申请日：1998-08-26

申请人： DELCATH SYSTEMS INC

发明人： GLICKMAN MORTON G

IPC分类号： A61F2/958 ,  A61M1/16 ,  A61M1/36 ,  A61M31/00 ,  A61M25/10

CPC分类号： A61M25/1011 ,  A61M1/1698 ,  A61M1/3615

公开(公告)号：EP0331710B1

公开(公告)日：1994-04-27

申请号：EP88908482.8

申请日：1988-08-08

申请人： CANOPY EDGE, INC.

发明人： Calderon, Reynaldo

IPC分类号： A61M25/00

CPC分类号： A61M25/00 ,  A61M1/3615 ,  A61M25/0026 ,  A61M25/1011 ,  A61M37/00 ,  A61M2025/09183 ,  A61M2025/1015

摘要： Tumors in the body of a patient are studied in situ by a monitor (12), such as computer assisted tomography, X-ray or the like, while optimal flow paths through the tumor area are established. A catheter (52) with a suction lumen (50) and an infusion lumen (25), with seals (22, 56) associated with each, is placed in the patient's vein near the tumor. Flow is then sealed in the vein with the infusion seal (56). A carrier medium dye is injected into the tumor at selected flow rates and differential pressures. Flow of the dye through the tumor is observed on the monitor (12) to determine optimal retrograde perfusion paths through the tumor for the selected flow rates and differential pressures. Once the optimal perfusion paths are noted, microspheres with active ingredients, such as chemotherapy, can be selectively perfused through each of the paths in the tumor at desired flow rates, pressures and active ingredient dosages.