公开(公告)号：EP0957750A1

公开(公告)日：1999-11-24

申请号：EP96936827.0

申请日：1996-10-21

Applicant: Cytometrics, Inc.

Inventor： GRONER, Warren ,  NADEAU, Richard, G.

IPC: G01N33 ,  A61B5 ,  G01N15 ,  G01N21 ,  G06F19

CPC classification number: A61B5/1455 ,  A61B5/0261 ,  A61B5/14535 ,  A61B5/411 ,  G01N15/05 ,  G01N15/06 ,  G01N15/1475 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1497

Abstract: Reflected imaging is used to perform non-invasive, in vivo analysis of a subject's vascular system. A raw reflected image (110) is normalized with respect to the background to form a corrected reflected image (120). An analysis image (130) is segmented from the corrected reflected image to include a scene of interest for analysis. The method and apparatus can be used to determine such characteristics as the hemoglobin concentration per unit volume of blood, the number of white blood cells per unit volume of blood, a mean cell volume, the number of platelets per unit volume of blood, and the hematocrit. Cross-polarizers (1510 and 1520) can be used to improve visualization of the reflected image.

公开(公告)号：EP1217937A1

公开(公告)日：2002-07-03

申请号：EP00965386.6

申请日：2000-09-25

Applicant: Cytometrics, Inc.

Inventor： NADEAU, Richard, G., Jr. ,  SIMPSON, Ernel, O.

IPC: A61B1/00 ,  A61B5/00

CPC classification number: A61B1/00142 ,  A61B5/0075 ,  A61B5/0084 ,  A61B2090/0814

Abstract: A disposable protective cap (130) protects a probe (120) in a spectral imaging apparatus from direct contact with a subject's tissues. An optically transparent face (212), permits light to be transmitted from the probe through the closed end (210) of the cap (130) with minimal optical distortion. At the open end (230) of the cap (130) are components (132) which interact with the probe (120) to assure that the cap is not used more than one time. These components can use electrical interaction to assure only a single disposable use of the cap. Mechanically interaction components (1202, 1204) can also be used, either alone or in combination with electrically interacting components to assure only a single use of the cap.

公开(公告)号：EP1126780A1

公开(公告)日：2001-08-29

申请号：EP99961549.5

申请日：1999-11-01

Applicant: Cytometrics, Inc.

Inventor： COOK, Christopher, A. ,  MEYERS, Mark, M.

IPC: A61B5/00

CPC classification number: A61B5/14535 ,  A61B5/0059 ,  G01N15/0211

Abstract: An in vivo imaging device having an illumination system that creates a virtual source within a tissue region of a subject in a non-invasive manner. The illumination system transforms a maximum amount of illumination energy from a light source into a high contrast illumination pattern. The illumination pattern is projected onto the object plane in a manner that maximizes the depth to which clear images of sub-surface features can be obtained. The high intensity portion of the illumination pattern is directed onto the object plane outside the field of view of an image capturing device that detects the image. In this configuration, scattered light from within the tissue region interacts with the object being imaged. This illumination technique provides for a high contrast image of sub-surface phenomena such as vein structure, blood flow within veins, gland structure, etc.

Abstract translation: 一种具有照明系统的体内成像装置，其以非侵入性方式在受试者的组织区域内产生虚拟源。 照明系统将来自光源的最大量的照明能量变换为高对比度照明图案。 将照明图案以使得可以获得次表面特征的清晰图像的深度最大化的方式投影到物体平面上。 照明图案的高强度部分被引导到检测图像的图像捕获装置的视场外的物体平面上。 在这种构造中，来自组织区域的散射光与被成像的物体相互作用。 这种照明技术提供了诸如静脉结构，静脉内的血流，腺体结构等的亚表面现象的高对比度图像。

公开(公告)号：EP1169625A1

公开(公告)日：2002-01-09

申请号：EP00917906.0

申请日：2000-03-15

Applicant: Cytometrics, Inc.

Inventor： COOK, Christopher, A. ,  GRONER, Warren ,  NADEAU, Richard, G.

IPC: G01J3/28 ,  G01J3/42 ,  G01N21/27

CPC classification number: G01J3/28 ,  G01J3/0213 ,  G01J3/0224 ,  G01J3/0264 ,  G01J2003/2866

Abstract: The invention comprises a system and method of calibrating a reflected spectral imaging apparatus used for analysis of living tissue. In addition to the reflected spectral imaging apparatus itself, the calibration apparatus comprises an optical filter that is placed between the light source used in the imaging apparatus and the object under analysis, and a calibration module. The filter is fabricated such that when the light is passed through the filter, an image is projected onto the focal plane where imaging is to take place within the object. The image projected by the filter comprises a plurality of areas, each having a different known optical density. For each area, the calibration module measures the intensity of the light reflected from the area and maps the light intensity measurement to the optical density known to be present at the area. This correspondence of light intensity measurements and known optical densities is then used to calibrate the reflected spectral imaging apparatus.