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公开(公告)号：EP0935664B1
公开(公告)日：2009-06-24
申请号：EP97944777.8
申请日：1997-08-21
申请人： EVAX Technologies AG
CPC分类号： C12N15/73
摘要： The present invention concerns a process for selecting new PR- or PL-operator sequences of lambdoid phages which, compared to wild-type sequences, have a different thermostability for the binding of a repressor. In addition, the invention discloses new mutated PR- or PL- operator sequences and their use for temperature-regulated expression of genes and for producing improved vaccines.
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公开(公告)号：EP0935664A2
公开(公告)日：1999-08-18
申请号：EP97944777.0
申请日：1997-08-21
申请人： EVAX Technologies AG
CPC分类号： C12N15/73
摘要： The present invention concerns a process for selecting new PR- or PL-operator sequences of lambdoid phages which, compared to wild-type sequences, have a different thermostability for the binding of a repressor. In addition, the invention discloses new mutated PR- or PL- operator sequences and their use for temperature-regulated expression of genes and for producing improved vaccines.
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公开(公告)号：EP0540525B1
公开(公告)日：1999-09-22
申请号：EP91909986.1
申请日：1991-05-24
申请人： EVAX Technologies AG
CPC分类号： C07K14/005 , A61K39/00 , A61K39/39 , A61K2039/523 , A61K2039/55594 , C07K16/1203 , C12N1/06 , C12N2795/10022
摘要： The invention concerns a modified bacterium obtained by transformation of a Gram-negative bacterium with the gene of a lytically active membrane protein from bacteriophages or with the gene of a lytically active toxin-release gene or with genes which contain sequences which code for lytic proteins, cultivation of the bacterium, expression of this lysis gene and isolation of the bacterium modified in this way from a culture medium for use as a vaccine or adjuvant.
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