公开(公告)号：EP2096164A1

公开(公告)日：2009-09-02

申请号：EP07739894.9

申请日：2007-03-27

申请人： National University Corporation Kagawa University ,  Rare Sugar Production Technical Research Laboratories, LLC ,  Fushimi Pharmaceutical Company, Limited ,  Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo ,  Matsutani Chemical Industry Co., Ltd.

发明人： IZUMORI, Ken ,  MORIMOTO, Kenji ,  TAKATA, Goro ,  TOKUDA, Masaaki ,  TSUJISAKA, Yoshio ,  TAKESHITA, Kei ,  TSUSAKI, Keiji ,  OKUMA, Kazuhiro

IPC分类号： C12N1/20 ,  A61K8/60 ,  C12N9/04 ,  C12P7/18 ,  C12P19/02

CPC分类号： C12R1/01 ,  A61K8/60 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/0006 ,  C12P19/02

摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.
Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.

摘要翻译： 问题：在生产脱氧多元醇脱氢酶的能力提供了一个微生物与。 用于解决方法：一种微生物，属于肠杆菌属的与在位置C2和C3象核糖醇或L-艾杜糖醇的以产生用于相同的结构的多元醇脱氧脱氢酶的能力。 肠杆菌属（保藏号NITE P-271）的细菌细胞IK7。 一种生产脱氧酮糖包括允许培养含有由本发明的微生物的培养或允许脱氧多元醇脱氢酶与在位置C2和C3为含有相同的结构的脱氧多羟基化合物的溶液中反应而获得的脱氧多元醇脱氢酶方法 确实核糖醇或L-艾杜糖醇的氧化脱氧多羟基化合物，以产生相应脱氧酮糖，然后收集所述脱氧酮糖。 脱氧多羟基化合物是1-脱氧-D-蒜糖醇，而相应的脱氧酮糖是1-脱氧-L-阿洛酮糖。 否则，脱氧多羟基化合物是L-rhamnitol，而相应的脱氧酮糖是1-脱氧-L-果糖。

公开(公告)号：EP2103625A1

公开(公告)日：2009-09-23

申请号：EP07739605.9

申请日：2007-03-26

申请人： National University Corporation Kagawa University ,  Rare Sugar Production Technical Research Laboratories, LLC ,  Fushimi Pharmaceutical Company, Limited ,  Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo ,  Matsutani Chemical Industry Co., Ltd.

发明人： IZUMORI, Ken ,  MORIMOTO, Kenji ,  TAKATA, Goro ,  TOKUDA, Masaaki ,  TSUJISAKA, Yoshio ,  TAKESHITA, Kei ,  TSUSAKI, Keiji ,  OKUMA, Kazuhiro

IPC分类号： C07K14/195 ,  C12N1/20 ,  C12N9/90 ,  C12P19/24

CPC分类号： C12N9/90 ,  C12P19/24 ,  C12R1/01

摘要： Object: To provide a thermostable L-ribose isomerase.
Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45°C, optimal pH of pH 9. 0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45°C during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.

摘要翻译： 目的：提供热稳定的L-核糖异构酶。 解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH为9.0（甘氨酸 - NaOH缓冲液）的最佳pH，以及稳定的物理化学性质，例如在pH 9.0的热处理期间高达45℃的温度稳定性为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。 醛糖和酮糖之间的转化方法，其包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸龙胆菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇，使醛糖异构化，产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-糖精，D-托洛糖，D-甘露糖，L-阿洛糖和L-古洛糖。

公开(公告)号：EP1875928A1

公开(公告)日：2008-01-09

申请号：EP06731999.6

申请日：2006-04-17

申请人： Shinshu University ,  National University Corporation Kagawa University ,  Fushimi Pharmaceutical Company, Limited

发明人： KOYAMA, Shozo,Shinshu Uni. School of Medicin ,  TOKUDA, Masaaki,Faculty of Medicine ,  HORI, Yoshiyuki,Fushimi Pharmaceutical Co., Ltd. ,  OHSAKA, Kazumasa,Fushimi Pharmaceutical Co., Ltd.

IPC分类号： A61K49/00

CPC分类号： A61K49/221 ,  A61K31/22

摘要： A drug in the form of a solid preparation soluble or suspendable in water or an aqueous solution characterized by containing at least one biocompatible, gastric motility suppressing component such as triacetin, which is capable of transmitting ultrasonic wave to a target organ via the solution pooled in the body in a noninvasive examination (for example, an ultrasonic examination of an abdominal organ), identifying the area in which the solution exists, or clarifying the boundary of the solution and an organ in contact therewith, is employed as an auxiliary agent in the examination. In addition, triacetin can be extensively used as a gastric motility suppressor.

摘要翻译： 在固体制剂的水溶性或水可悬浮的或由含有至少一种生物相容的，胃动力抑制成分为特征的wässrige溶液形式的药物：如三醋精，所有这一切都能够经由在合并的溶液中发射超声波到目标器官的 在非侵入性检查的身体（例如，在腹部器官的超声检查）标识所述溶液存在的区域，或澄清溶液的边界和在接触那里与器官，被用作在助剂 检查。 此外，三醋精可以被广泛用作胃能动性抑制剂。

公开(公告)号：EP1388530A4

公开(公告)日：2006-01-18

申请号：EP02724761

申请日：2002-05-10

申请人： FUSHIMI PHARMACEUTICAL COMPANY

发明人： YOSHINO A ,  IZUMORI KEN ,  TAKAHASHI T

IPC分类号： C07C29/145 ,  C07C29/78 ,  C07C31/26

CPC分类号： C07C29/145 ,  C07C31/26

摘要： A method for producing a sugar alcohol having six carbon atoms, characterized in that a ketohexose such as psicose, tagatose, sorbose, or the like is hydrogenized in the presence of a catalyst containing a metal selected from the elements belonging to Group 8 of the Periodic Table such as nickel, ruthenium, platinum, palladium or the like. The method allows the production of a large amount of a sugar alcohol having six carbon atoms with good efficiency with easy separation and recovery of a catalyst, and can be used also for producing a mixture of two or more types of sugar alcohol having a desired ratio with good efficiency.

公开(公告)号：EP1875928A4

公开(公告)日：2012-03-21

申请号：EP06731999

申请日：2006-04-17

申请人： UNIV SHINSHU ,  UNIV KAGAWA NAT UNIV CORP ,  FUSHIMI PHARMACEUTICAL COMPANY LTD

发明人： KOYAMA SHOZO ,  TOKUDA MASAAKI ,  HORI YOSHIYUKI ,  OHSAKA KAZUMASA

IPC分类号： A61K49/22 ,  A61K31/22

CPC分类号： A61K49/221 ,  A61K31/22

公开(公告)号：EP1538200A1

公开(公告)日：2005-06-08

申请号：EP03752940.1

申请日：2003-05-22

申请人： Fushimi Pharmaceutical Company, Limited ,  Teikoku Seiyaku Co., Ltd. ,  Kagawa University ,  Shikoku Research Institute Incorporated ,  KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad, Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： C12N5/08 ,  A23L1/30 ,  A61K7/00 ,  A61K31/7004

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

摘要翻译： 利用一种罕见糖的生理活性的方法，worin生理活性敏感细胞与罕见糖处理，以改变细胞的功能。 被引入生理活性敏感的细胞，并且对修饰细胞功能的影响包含组合物，如在，稀有糖类活性成分全部。 该细胞是人类细胞。 该组合物是一种功能性食品，药物或化妆品。 稀有糖类是属于醛糖和/或酮糖罕见的糖。 醛糖是D-阿洛糖，并将细胞选自癌细胞增殖抑制活性敏感的细胞和活性氧产生抑制活性敏感的细胞的选择。 所述酮糖是D-阿洛酮糖，并且所述细胞选自趋化因子分泌的抑制活性敏感的细胞，小神经胶质细胞迁移抑制活性敏感的细胞，和低血糖活性敏感的细胞的选择。

公开(公告)号：EP2364710A1

公开(公告)日：2011-09-14

申请号：EP11169415.4

申请日：2003-05-22

申请人： Fushimi Pharmaceutical Company, Limited ,  TEIKOKU SEIYAKU CO., LTD. ,  National University Corporation Kagawa University

发明人： Izumori, Ken ,  Tokuda, Masaaki ,  Itano, Toshifumi ,  Miyamoto, Osamu ,  Ishida, Toshihiko ,  Murao, Koji ,  Tasaka, Taizo ,  Muneuchi, Gan ,  Yamaguchi, Fuminori ,  Tanaka, Terukazu ,  Hossain, Mohammed, Akram ,  Ueki, Masaaki ,  Hirooka, Kazuyuki ,  Taminato, Asahiko ,  Tsusaki, Keiji ,  Takahashi, Takeo ,  Nagata, Mitsuhiro ,  Ishida, Yutaka

IPC分类号： A61K31/7004 ,  A61P35/00 ,  A61P39/06 ,  A61P25/00 ,  A61P9/10 ,  A61P27/02

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells.

摘要翻译： 利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。 作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。 细胞是人类细胞。 组合物是功能性食品，药物或化妆品。 稀有的糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。

公开(公告)号：EP1538200A4

公开(公告)日：2007-06-06

申请号：EP03752940

申请日：2003-05-22

申请人： FUSHIMI PHARMACEUTICAL COMPANY ,  TEIKOKU SEIYAKU KK ,  UNIV KAGAWA ,  SHIKOKU RESEARCH INST INC ,  HAYASHIBARA BIOCHEM LAB

发明人： IZUMORI KEN ,  TOKUDA MASAAKI ,  ITANO TOSHIFUMI ,  MIYAMOTO OSAMU ,  ISHIDA TOSHIHIKO ,  MURAO KOJI ,  TASAKA TAIZO ,  MUNEUCHI GAN ,  YAMAGUCHI FUMINORI ,  TANAKA TERUKAZU ,  HOSSAIN MOHAMMAD AKRAM ,  UEKI MASAAKI ,  HIROOKA KAZUYUKI ,  TAMINATO TOMOHIKO ,  TSUSAKI KEIJI ,  TAKAHASHI TAKEO ,  NAGATA MITSUHIRO ,  ISHIDA YUTAKA

IPC分类号： A23L1/09 ,  A23L1/30 ,  A61K8/60 ,  A61K31/7004 ,  A61Q19/00 ,  C12N5/08 ,  A61K7/00

CPC分类号： A61Q19/00 ,  A23L29/30 ,  A23L33/10 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

公开(公告)号：EP1388530A1

公开(公告)日：2004-02-11

申请号：EP02724761.8

申请日：2002-05-10

申请人： Fushimi Pharmaceutical Company, Limited

发明人： YOSHINO, A. Fushimi Pharmaceutical Company, Ltd. ,  IZUMORI, Ken ,  TAKAHASHI, T. Fushimi Pharmaceutical Company, Ltd.

IPC分类号： C07C29/145 ,  C07C29/78 ,  C07C31/26

CPC分类号： C07C29/145 ,  C07C31/26

摘要： A process for producing sugar alcohols having six carbon atoms, which comprises hydrogenating ketohexose, such as psicose, tagatose, sorbose and the like, in the presence of a catalyst containing a metal selected from the elements belonging to the eighth family in the periodic table, such as nickel, ruthenium, platinum, palladium and the like, is provided. According to this process, sugar alcohols having six carbon atoms can be produced efficiently at a large amount, the separation and recovering of the catalyst after completing the reaction are facilitated, and sugar alcohols having a desired production ratio can be produced efficiently.

摘要翻译： 一种制备具有6个碳原子的糖醇的方法，该方法包括在含有选自元素周期表第八族元素的金属的催化剂存在下氢化酮己糖，如木糖，塔格糖，山梨糖等， 例如镍，钌，铂，钯等。 根据该方法，可以高效率地制造具有6个碳原子的糖醇，从而促进了反应完成后的催化剂的分离和回收，能够有效地制造具有所需生产率的糖醇。