公开(公告)号：EP4549591A1

公开(公告)日：2025-05-07

申请号：EP23831932.1

申请日：2023-06-29

Applicant: Seoul National University R&DB Foundation ,  Institute for Basic Science

Inventor： KIM, Vic Narry ,  SEO, Jenny ,  JUNG, Soo-Jin

IPC: C12Q1/70 ,  C12Q1/6806 ,  C12N15/10

Abstract: The present disclosure relates to a method of screening a regulatory element for enhancing mRNA translation, a novel regulatory element resulting from the method, and uses thereof. Through the screening method of the present disclosure, a novel regulatory element capable of enhancing mRNA translation may be obtained. Furthermore, the novel regulatory element may increase the expression of a target protein and as such, may be applied to various fields, depending on the intended use of the target protein.

公开(公告)号：EP4534671A1

公开(公告)日：2025-04-09

申请号：EP23816336.4

申请日：2023-05-30

Applicant: Institute for Basic Science ,  Korea Advanced Institute of Science and Technology

Inventor： LEE, C. Justin ,  SA, Moonsun ,  BHALLA, Mridula Neeraj Kumar ,  KIM, Jin Kuk ,  JUNG, Eunji ,  PARK, Minsung

IPC: C12N15/113 ,  A61K31/7088 ,  A61K48/00 ,  A61P25/28

Abstract: The present invention relates to antisense oligomers against monoamine oxidase B and uses thereof, and more particularly, to antisense oligomers that modulate the expression level of a gene encoding monoamine oxidase B, specifically the mRNA of the gene, or a protein encoded thereby, and uses thereof for preventing, alleviating or treating liver disease, obesity or neurological disease.

公开(公告)号：EP4524244A1

公开(公告)日：2025-03-19

申请号：EP23803902.8

申请日：2023-05-15

Applicant: Seoul National University R&DB Foundation ,  Institute for Basic Science

Inventor： KIM, V. Narry ,  LEE, Young-Yoon ,  KIM, Haedong

IPC: C12N9/22 ,  C12N15/113

Abstract: The present invention relates to a DICER cleavage site motif that is a sequence determinant of dsRNA processing by DICER. Using the DICER cleavage site motif according to the present invention can strongly promote the processing of dsRNA by DICER, and thereby promote RNA interference. In addition, the DICER cleavage site motif according to the present invention is an integrated and conserved determinant of substrate recognition by DICER, and can be applied to any technique capable of generating siRNA through DICER processing. Thus, the present invention can greatly contribute to future studies using DICER processing, for example, studies on the biological or therapeutic use of small RNAs.

公开(公告)号：EP4245749A1

公开(公告)日：2023-09-20

申请号：EP21892368.8

申请日：2021-11-12

Applicant: Institute for Basic Science ,  Korea Institute of Science and Technology

Inventor： LEE, Chang Jun ,  CHUN, Heejung ,  WON, Woojin ,  PARK, Ki Duk ,  PARK, Jong Hyun ,  PAE, Ae Nim ,  CHOI, Ji Won ,  LEE, Elijah ,  PARK, Sun Jun ,  KIM, Hyeon Jeong ,  KIM, Yoowon ,  KIM, Byung Eun ,  KIM, Siwon

IPC: C07C211/53 ,  A61K31/136 ,  A61P25/28 ,  A23L33/10 ,  A23L29/00

Abstract: The present invention provides a novel aminoaromatic compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition that is for preventing or treating neurodegenerative diseases and comprises same as an active ingredient, and a health functional food composition for preventing or ameliorating neurodegenerative diseases.

公开(公告)号：EP4221822A1

公开(公告)日：2023-08-09

申请号：EP21876524.6

申请日：2021-09-30

Applicant: The Board Of Trustees Of The Leland Stanford Junior University ,  Institute for Basic Science

Inventor： LEE, Jin Hyung ,  SHIN, Hee-Sup

IPC: A61N1/36 ,  A61N1/40

公开(公告)号：EP4194557A1

公开(公告)日：2023-06-14

申请号：EP22208378.4

申请日：2015-08-06

Applicant: Institute for Basic Science ,  Toolgen Incorporated

Inventor： KIM, Seok Joong ,  KIM, Eun Ji

IPC: C12N15/63 ,  C12N1/21 ,  C12N9/16 ,  C12N9/22 ,  C12N15/10

Abstract: The disclosure provided herewith relates to a Campylobacter jejuni CRISPR/CAS system-derived RGEN and a use thereof.

公开(公告)号：EP4147806A1

公开(公告)日：2023-03-15

申请号：EP21799843.4

申请日：2021-05-07

Applicant: Seoul National University R & DB Foundation ,  Institute for Basic Science

Inventor： HYEON, Taeghwan ,  SUNG, Yung-Eun ,  YOO, Tae Yong ,  YOO, Ji Mun

IPC: B22F1/00 ,  B22F1/02 ,  B01J37/08 ,  B01J37/02 ,  B01J23/89 ,  B01J21/18 ,  B01J35/02 ,  B01J35/00 ,  H01M4/92

Abstract: Alloy nanoparticles, and a method for forming the alloy nanoparticles, a alloy nanocatalyst comprising the alloy nanoparticles are provided. The alloy nanoparticles are formed by a method comprising mixing a first metal complex including a first metal and a second metal complex including a second metal to form a multimetal compound and heat-treating the multimetal compound to form a alloy compound. The first metal and the second metal comprise transition metal, the first metal complex comprises a pyridine-based ligand, and a carbon shell containing N is formed on the surface of the alloy compound by the heat treatment.

公开(公告)号：EP3984558A1

公开(公告)日：2022-04-20

申请号：EP20813525.1

申请日：2020-06-01

Applicant: Seoul National University R & DB Foundation ,  Institute for Basic Science

Inventor： KIM, V. Narry ,  YEO, Jinah ,  KIM, Dongwan ,  LEE, Young-Suk ,  JUNG, Soo-Jin

IPC: A61K48/00 ,  A61K31/713 ,  A61K31/7105 ,  A61P31/20 ,  A61P31/22 ,  C12Q1/70 ,  C12N15/113

Abstract: The present invention relates to a technology for preventing or treating virus infection and infectious disease by inducing a mixed tailing regarding an RNA virus

公开(公告)号：EP3561059A1

公开(公告)日：2019-10-30

申请号：EP17885347.9

申请日：2017-12-22

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  KIM, Kyoung Mi ,  RYU, Seuk Min

IPC: C12N15/10 ,  C12N15/85 ,  C12N15/877 ,  C12N9/16 ,  C12N9/78 ,  C12N9/02 ,  C07K14/47

Abstract: Provided are a base editing composition comprising deaminase and target-specific nuclease, a base editing method using the base editing composition, and a method for producing a genetically modified animal. The base editing composition has a base editing activity in mammalian embryos.

公开(公告)号：EP3308706A1

公开(公告)日：2018-04-18

申请号：EP16807744.4

申请日：2016-06-03

Applicant: Seoul National University R&DB Foundation ,  Institute for Basic Science

Inventor： KIM, Daehyeong ,  HYEON, Taeghwan ,  CHOI, Seunghong ,  LEE, Hyunjae ,  CHOI, Taekyu

IPC: A61B5/145 ,  A61B5/00 ,  G01N27/327 ,  G01N27/48 ,  G01N33/53 ,  G01N33/66 ,  H01L51/00 ,  G01N27/30

CPC classification number: A61M5/1723 ,  A61B5/00 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/4266 ,  A61B2562/0261 ,  A61B2562/12 ,  A61M5/00 ,  A61M37/0015 ,  A61M2205/3368 ,  A61M2205/3569 ,  A61M2205/36 ,  A61M2230/201 ,  A61M2230/208 ,  C12Q1/006 ,  G01N27/3271 ,  G01N27/3278 ,  G01N33/66 ,  G01N33/84

Abstract: Provided are a biosensor and a method for forming the same, a glucose control system, a method for forming the glucose control system, and a method for controlling glucose using the glucose control system. The biosensor comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit, and an electrode unit connected to the bridge unit, wherein the sensing unit comprises a graphene layer. The method for forming the biosensor that comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit and an electrode unit connected to the bridge unit, comprises forming a lower insulation layer, forming a conductive electrode layer on the lower insulation layer, forming a graphene layer on the conductive electrode layer and forming a reaction layer on the graphene layer.
The glucose control system comprises a sensor unit comprising a glucose sensor, a glucose regulation unit regulating glucose concentration in a body of a user and a control unit controlling the sensor unit and the glucose regulation unit. The method for forming a glucose control system comprises forming a sensor unit comprising a glucose sensor, forming a glucose regulation unit and packaging the sensor unit and the glucose regulation unit.

Abstract translation: 本发明提供生物传感器及其形成方法，葡萄糖控制系统，葡萄糖控制系统的形成方法以及使用葡萄糖控制系统的葡萄糖控制方法。 生物传感器包括至少一个传感器，其包括感测单元，连接到感测单元的桥单元以及连接到桥单元的电极单元，其中感测单元包括石墨烯层。 用于形成包括至少一个传感器的生物传感器的方法包括感测单元，连接到感测单元的桥单元和连接到桥单元的电极单元，包括形成下绝缘层，在下部形成导电电极层 绝缘层，在导电电极层上形成石墨烯层，并在石墨烯层上形成反应层。 葡萄糖控制系统包括传感器单元，控制单元控制传感器单元和葡萄糖调节单元，所述传感器单元包括葡萄糖传感器，葡萄糖调节单元，用于调节用户体内的葡萄糖浓度。 形成葡萄糖控制系统的方法包括形成包括葡萄糖传感器的传感器单元，形成葡萄糖调节单元并封装传感器单元和葡萄糖调节单元。