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1.发明公开DEVICE AND METHOD TO TREAT OR PREVENT JOINT DEGENERATION 审中-公开VORRICHTUNG VERFAHREN ZUR BEHANDLUNG ODER PREVENTION VON GELENKVERSCHLEISS
公开(公告)号：EP3154552A1
公开(公告)日：2017-04-19
申请号：EP15807515.0
申请日：2015-06-10
IPC分类号： A61K31/726 , A61K31/728 , A61K31/7008 , A61P19/02 , A61N2/06
CPC分类号： A61K31/737 , A61F13/02 , A61K9/0014 , A61K9/009 , A61K9/7084 , A61K31/7008 , A61K31/726 , A61K31/728 , A61K47/20 , A61K47/36 , A61K2300/00
摘要： A method for the delivery of aggrecan precursors to the joint of a subject, comprising the steps of: a) applying a composition comprising one or more aggrecan precursors chosen from the list comprising hyaluronic acid, glucosamine sulfate and/or chondroitin sulfate to the skin of the subject on or near a joint, wherein the composition is applied between the skin and a flexible magnetic film.
摘要翻译： 一种将聚集蛋白聚糖前体递送至受试者的关节的方法，包括以下步骤：a）将包含一种或多种选自包含透明质酸，硫酸葡糖胺和/或硫酸软骨素的聚集蛋白聚糖前体的组合物施用于 所述受试者在关节上或附近，其中所述组合物施用于皮肤和柔性磁性膜之间。
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公开(公告)号：EP2753395A1
公开(公告)日：2014-07-16
申请号：EP12829533.4
申请日：2012-09-07
发明人： EDWARDS, Jeffrey D.
IPC分类号： A61M37/00
摘要： A device for delivering an active agent to a dermal or mucosal surface comprising: a) a first portion configured to define a delivery surface for presentation to a dermal or mucosal surface to deliver an active agent; and b) a second portion configured as a body to be held by a user further comprising a means for driving the passage of the active agent across the dermal or mucosal surface wherein the first portion and the second portion are adapted to be releasably interconnected and wherein the means for driving the passage of the active agent across the dermal or mucosal surface comprises an electromagnetophoresis dermaportation device located immediately adjacent the point of interconnection to the first portion.
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3.发明公开
公开(公告)号：EP1694408A1
公开(公告)日：2006-08-30
申请号：EP04797047.0
申请日：2004-11-18
发明人： EDWARDS, Jeffrey D
摘要： An apparatus (40) is disclosed for facilitating transdermal delivery of therapeutic substances. The apparatus (40) comprises means (44) for producing an electromagnetic field, control means (26, 34) arranged to control said field producing means to alternately produce active and substantially inactive electromagnetic field portions. Each active electromagnetic field portion includes an electromagnetic field packet having a plurality of successive electromagnetic field pulses, and each substantially inactive electromagnetic field portion includes no electromagnetic field pulses. During use, when the electromagnetic field is incident on a patient, dermal permeability is increased. A corresponding method is also disclosed.
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公开(公告)号：EP2806940A1
公开(公告)日：2014-12-03
申请号：EP13740749.0
申请日：2013-01-24
发明人： EDWARDS, Jeffrey D.
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61N2/002 , A61N2/06 , F04C2270/041
摘要： A device for delivery of a measured or predetermined dose of an active agent to a dermal or mucosal surface comprising: a) a deformabie chamber comprising at least one dome-shaped member defining a reservoir for an active agent; and b) a porated disc.
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公开(公告)号：EP3310449A1
公开(公告)日：2018-04-25
申请号：EP16810603.7
申请日：2016-06-17
CPC分类号： B01D17/041 , A61K8/675 , A61K8/678 , A61K2800/87 , A61Q19/00 , B01D17/042 , B01D17/047 , B01D19/0047
摘要： The present invention provides a method for the separation of a mixture having a first component and a second component, the method comprising the steps of: (a) applying at least two destabilizing energy forms to the mixture to destabilize the mixture, wherein the destabilizing energy forms are chosen from the list comprising: mechanical shear force, thermal energy, and/or surface energy; and (b) applying at least one enriching energy form to the mixture to form a first region that is enriched in a first component relative to the second component and a second region that is enriched in the second component relative to the first component, wherein the enriching energy form is surface energy.
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8.发明公开AN APPARATUS AND METHOD OF TREATMENT UTILIZING A VARYING ELECTROMAGNETIC ENERGISATION PROFILE 审中-公开设备和治疗与变化的电磁ENERGISIERUNGSPROFIL方法
公开(公告)号：EP2445584A1
公开(公告)日：2012-05-02
申请号：EP10791059.8
申请日：2010-06-22
发明人： EDWARDS, Jeffrey, D.
CPC分类号： A61N1/40 , A61N1/0412 , A61N1/0428 , A61N1/327 , A61N2/02
摘要： The present invention relates to an apparatus and method for improving the delivery of desirable substances across a membrane utilizing a varying electromagnetic energisation profile. More particularly, the invention provides methods for modifying the cellular environment of such membranes and the behaviour of substance molecules during transport across a membrane. In use, the profile will have application in, enhancing transmembrane delivery of substances (such as pharmaceuticals, nutraceuticals, biopharmaceuticals and cosmeceuticals), and/or enhancing or expanding a cellular cohort of membranes and surrounding tissues.
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公开(公告)号：EP2575950A1
公开(公告)日：2013-04-10
申请号：EP11785905.8
申请日：2011-05-24
发明人： EDWARDS, Jeffrey
IPC分类号： A61M37/00
CPC分类号： A61C19/063 , A46B15/0026 , A46B2200/1066 , A46D1/0207 , A61C19/066 , A61K8/19 , A61K2800/47 , A61M35/00 , A61N2/06 , A61Q11/00
摘要： A method for the delivery of an oral care active agent comprising the following step: applying an active agent(s) between a target oral biological barrier and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier.
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10.发明授权
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