公开(公告)号：EP4455264A1

公开(公告)日：2024-10-30

申请号：EP22911317.0

申请日：2022-12-21

申请人： Kyowa Hakko Bio Co., Ltd. ,  KIRIN HOLDINGS KABUSHIKI KAISHA

发明人： SUGITA, Tomotoshi ,  SANPEI, Sotaro

IPC分类号： C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  C12N15/31 ,  C12P19/00

摘要： The present invention relates to a microorganism having a reduced or inactivated activity of a protein according to any one of the following [1] to [3] and improved productivity of lacto-N-triose II or an oligosaccharide having a lacto-N-triose II (LNTII) skeleton as compared with a parent strain: [1] a protein consisting of the amino acid sequence represented by SEQ ID NO: 2 or 4, [2] a mutant protein having an oligosaccharide transporting activity and consisting of an amino acid sequence in which 1 to 20 amino acids are deleted, substituted, inserted, or added in the amino acid sequence represented by SEQ ID NO: 2 or 4, and [3] a homologous protein having an oligosaccharide transporting activity and consisting of an amino acid sequence having an identity of 90% or more with the amino acid sequence represented by SEQ ID NO: 2 or 4.

公开(公告)号：EP4424177A1

公开(公告)日：2024-09-04

申请号：EP22887145.5

申请日：2022-10-27

申请人： Japan as Represented by Director-General of National Institute of Infectious Diseases ,  KIRIN HOLDINGS KABUSHIKI KAISHA

发明人： ISHII, Hiroshi ,  MATANO, Tetsuro ,  JONAI, Kenta ,  OHSHIO, Konomi ,  FUJIWARA, Daisuke

IPC分类号： A23L33/135 ,  A61K35/744 ,  A61P31/14

CPC分类号： A61K35/744 ,  A61P31/14 ,  A23L33/135

摘要： An object of the present invention is to provide a novel agent for inhibiting proliferation of SARS-CoV-2 and a novel agent for preventing onset of COVID-19. According to the present invention, there is provided an agent for inhibiting proliferation of SARS-CoV-2 comprising a lactic acid bacterium as an active ingredient. Also, according to the present invention, there is provided an agent for preventing onset of COVID-19 comprising a lactic acid bacterium as an active ingredient. The lactic acid bacterium which is the active ingredient of the present invention is preferably Lactococcus lactis subsp. lactis. The agent of the present invention is preferably in the form of a food composition.

公开(公告)号：EP3763798A1

公开(公告)日：2021-01-13

申请号：EP19763400.9

申请日：2019-03-01

申请人： KIRIN HOLDINGS KABUSHIKI KAISHA

发明人： SUGIHARA, Yoshihiko ,  EGUCHI, Takahiro ,  MURAKAMI, Hiroyuki

IPC分类号： C09K3/00 ,  B01F3/04 ,  C01B32/50

摘要： An object of the present invention is to provide an ultrafine bubble generating agent capable of easily generating ultrafine bubbles in a liquid without requiring an ultrafine-bubble generator, a method for producing an ultrafine bubble-containing liquid, an ultrafine bubble-containing liquid produced by the same production method, and the like. The method for producing an ultrafine bubble-containing liquid of the present invention comprises melting ice having a CO 2 -content rate of 3 wt% or more (preferably a CO 2 hydrate).

公开(公告)号：EP2829607B1

公开(公告)日：2019-08-28

申请号：EP13764240.1

申请日：2013-03-22

申请人： Kirin Holdings Kabushiki Kaisha

发明人： UMEMOTO Naoyuki ,  OTSUKA Masako

IPC分类号： C12N15/82 ,  C12N15/53 ,  C12N15/113 ,  A01H1/00

公开(公告)号：EP3251684A1

公开(公告)日：2017-12-06

申请号：EP17183259.5

申请日：2011-12-15

申请人： Kirin Holdings Kabushiki Kaisha

发明人： Manabe, Fumitoshi ,  Taniguchi, Yoshimasa ,  Kobayashi, Yumie ,  Katayama, Mikio

IPC分类号： A61K36/60 ,  A23L33/105 ,  A61P3/04 ,  A61P3/06 ,  A61K36/185

CPC分类号： A61K36/185 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/332 ,  A23V2250/21

摘要： The present invention relates to a food product and food additive comprising a hop oxidation-reaction product or an extract thereof as well as a fat accumulation suppressing agent and a weight gain suppressing agent having it as an active ingredient.

摘要翻译： 本发明涉及包含啤酒花氧化反应产物或其提取物以及脂肪蓄积抑制剂和以其为有效成分的增重抑制剂的食品和食品添加剂。

公开(公告)号：EP2433502B1

公开(公告)日：2016-05-04

申请号：EP10777800.3

申请日：2010-05-20

申请人： Kirin Holdings Kabushiki Kaisha

发明人： MANABE, Fumitoshi ,  KATAYAMA, Mikio ,  IMASATO Youji

IPC分类号： A23L27/00 ,  A23L2/56 ,  A23L2/70 ,  A61K47/46

CPC分类号： A23F5/465 ,  A23L2/56 ,  A23L2/70 ,  A23L2/74 ,  A23L19/09 ,  A23L21/15 ,  A23L27/12 ,  A23L27/86 ,  A61K47/46

公开(公告)号：EP2653041A1

公开(公告)日：2013-10-23

申请号：EP11849749.4

申请日：2011-12-15

申请人： Kirin Holdings Kabushiki Kaisha

发明人： TANIGUCHI Yoshimasa ,  KOBAYASHI Yumie ,  MANABE Fumitoshi ,  KATAYAMA Mikio

IPC分类号： A23L1/30 ,  A61K9/14 ,  A61K36/00 ,  A61K36/18 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36 ,  A61P3/04 ,  A61P3/06

CPC分类号： C12C3/06 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/122 ,  A61K36/185 ,  A61K2236/10

摘要： The present invention relates to a hop extract having a reduced bitter taste which shows a fat absorption suppressing effect. More specifically the present invention relates to a hop extract oxidation-reaction product obtained by an oxidation-reaction of a hop extract.

摘要翻译： 本发明涉及具有降低的苦味的啤酒花提取物，其显示出脂肪吸收抑制效果。 更具体地，本发明涉及通过啤酒花提取物的氧化反应获得的啤酒花提取物氧化反应产物。

公开(公告)号：EP2471927A1

公开(公告)日：2012-07-04

申请号：EP10812057.7

申请日：2010-08-30

申请人： Kirin Holdings Kabushiki Kaisha

发明人： UMEMOTO Naoyuki ,  SASAKI Katsunori

IPC分类号： C12N15/29 ,  A01H5/00 ,  C07K14/415 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12Q1/68

CPC分类号： C12N15/8243 ,  C07K14/415 ,  C12N9/00 ,  C12N9/0071 ,  C12N15/8218 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Y114/00 ,  C12Y114/14001

摘要： An object of the present invention is to provide DNA of a glycoalkaloid biosynthetic enzyme of a solanaceous plant ( Solanaceae ) such as a potato. The present invention relates to a protein having glycoalkaloid biosynthetic enzyme activity of a solanaceous plant such as a potato and a method for producing/detecting a novel organism using a gene encoding the protein.

摘要翻译： 本发明的目的是提供诸如马铃薯的茄科植物（茄科）的糖生物碱生物合成酶的DNA。 本发明涉及具有马铃薯等茄科植物的糖生物碱生物合成酶活性的蛋白质，以及使用编码该蛋白质的基因来生产/检测新生物体的方法。

公开(公告)号：EP2143784A1

公开(公告)日：2010-01-13

申请号：EP08720640.5

申请日：2008-03-27

申请人： Kirin Holdings Kabushiki Kaisha

发明人： NISHIDA, Takeo ,  AWAYAMA, Hitoshi

IPC分类号： C12N1/20 ,  A61K35/74 ,  A61P37/08

CPC分类号： C12N1/005 ,  A61K35/747 ,  C12N1/20

摘要： It is to provide a lactic acid bacterium having a high antiallergic activity and stable antiallergic activity that can be used effectively in various product forms and in various use applications. By conducting a heat treatment at 60C or more and less than 100°C for 10 minutes or more and less than 60 minutes to Lactobacillus paracasei KW3110 strain or its mutant strain, the antiallergic activity of the lactic acid bacterium can be significantly increased to produce Lactobacillus paracasei KW3110 strain and its mutant strain having a stable antiallergic activity and high antiallergic activity. According to the present invention, an antiallergic composition comprising a lactic acid bacterial cell which antiallergic activity of the lactic acid bacterial cell has been significantly increased by the heat treatment of the present invention, or having a stable high antiallergic activity can be provided.

摘要翻译： 这是为了提供具有高抗过敏活性的和稳定的抗过敏活性的并可以以各种产品形态及各种用途的应用有效地使用的乳酸菌。 通过在60℃以上且小于100℃，10分钟或更长且小于60分钟，副干酪乳杆菌KW3110株或其变异株进行加热处理，该乳酸菌的抗过敏活性，可以显着增加，以产生乳杆菌 副干酪乳杆菌KW3110株及其突变株具有稳定的抗过敏活性和高抗过敏活性。 。根据本发明，在抗过敏组合物，其包含的乳酸菌菌体的抗过敏活性已经通过本发明的热处理是显着提高乳酸细菌细胞，或具有​​稳定的高抗过敏活性的可以提供。

公开(公告)号：EP1457564B1

公开(公告)日：2010-01-06

申请号：EP04006087.3

申请日：2004-03-15

申请人： Japan International Research Center for Agricultural Sciences ,  Kirin Holdings Kabushiki Kaisha

发明人： Shinozaki, Kazuko ,  Umemoto, Naoyuki, Kirin Holdings Kabushiki Kaisha ,  Mamiya, Kanji, Kirin Holdings Kabushiki Kaisha ,  Toguri, Toshihiro, Kirin Holdings Kabushiki Kaisha

IPC分类号： C12N15/82 ,  A01H5/00 ,  A01H5/02 ,  A01N3/00

CPC分类号： C12N15/8273 ,  C12N15/8261 ,  C12N15/8271 ,  Y02A40/146

摘要： Provided is a plant having improved efficiency in propagation by cutting resulting from the enhanced rooting efficiency, and improved vase life. A method of producing a transformed plant having improved rooting efficiency and/or prolonged vase life, comprising transforming a plant using a gene wherein a DNA encoding a protein that binds to a stress-responsive element contained in a stress-responsive promoter and regulates the transcription of a gene located downstream of the element is ligated downstream of the stress-responsive promoter.