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    CONFOCAL MICROSCOPE FOR IMAGING OF SELECTED LOCATIONS OF THE BODY OF A PATIENT
    2.
    发明公开
    CONFOCAL MICROSCOPE FOR IMAGING OF SELECTED LOCATIONS OF THE BODY OF A PATIENT 有权
    共焦显微镜图的患者的身体的选定点

    公开(公告)号：EP1636625A4

    公开(公告)日：2007-08-15

    申请号：EP04753135

    申请日：2004-05-20

    申请人： LUCID INC

    发明人： FOX WILLIAM J ,  DISTASIO CHRISTOPHER C ,  GRODEVANT SCOTT R

    IPC分类号： G02B21/00 ,  G02B7/00 ,  G02B21/36

    CPC分类号： G02B21/0048 ,  A61B5/0064 ,  A61B5/0068 ,  A61B5/6835 ,  G02B21/0012 ,  G02B21/0028 ,  G02B21/008 ,  G02B21/362

    摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient while providing for patient comfort. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The station (10) also supports a personal computer (PC) (26) for processing signals providing the images on the display and controlling the microscope. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. Controls (50) for the fine positioning and focusing are on the head (28) for ease of use. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.

    LASER TREATMENT SYSTEM WITH ELECTRONIC VISUALIZATION
    3.
    发明授权
    LASER TREATMENT SYSTEM WITH ELECTRONIC VISUALIZATION 失效
    LASERBEHANDLUNGSVORRICHTUNG MIT ELEKTRONISCHER VISUALISIERUNG

    公开(公告)号：EP0710136B1

    公开(公告)日：2004-02-04

    申请号：EP94923982.6

    申请日：1994-07-20

    申请人： LUCID, INC.

    发明人： ZAVISLAN, James M. ,  EASTMAN, Jay M.

    IPC分类号： A61N5/06

    CPC分类号： A61B18/203 ,  A61B18/20 ,  A61B2017/00756 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00904 ,  A61B2018/20359 ,  A61B2090/373

    摘要： A hand held microsurgical instrument (10) for applying laser energy to selected locations in an area under the skin to provide localized thermolysis of the tissue. The area is visualized while the laser beam is steered, using a deflection system, in X and Y coordinates. A telecentric optical system, in which a mirror (54) of the deflection system is located, directs the laser light essentially perpendicular to the area to be treated as the beam is scanned over the area. The optical system also focuses illumination light reflected from the area to a sensor matrix of a CCD video camera (48). The reflected illumination light is imaged essentially parallel to the optical axis in the object space thereby providing a precise image corresponding to the area. The laser beam may be tracked as it is deflected over the area by visualization thereof on a display or monitor associated with the camera.

    摘要翻译： 描述了一种用于将激光能量施加到皮肤下面的区域（或其他暴露的半透明组织）中的选定位置（位置）以在这些位置处提供局部光热解下面的组织的手持显微外科器械。 激光能量集中在组织内的一个点上。 该斑点具有足够小的尺寸，使得能量密度足以在组织内提供手术或治疗效果而不损伤表面组织。 例如，在皮肤病学中，该技术可用于破坏希望去除的血管中的内皮细胞，皮肤中的这种蜘蛛静脉（痣），毛囊以防止毛发生长或其它显微外科手术。 在X和Y坐标下，使用偏转系统对激光束进行转向，可视化该区域。 偏转系统的反射镜位于其中的远心光学系统在激光束在该区域上被扫描时基本垂直于待处理的区域。 光学系统还将从该区域反射的照明光聚焦到CCD摄像机的传感器矩阵。 反射的照明光基本上平行于对象空间中的光轴成像，从而提供对应于该区域的精确的高分辨率图像。 激光束可以被跟踪，因为它通过在与摄像机相关联的显示器或监视器上的可视化而在区域上偏转到所选择的位置。 然后，这些位置对于治疗医师是显而易见的，其然后可以实现束功率的增加或者使光束转动，从而在所选位置处理组织。

    TISSUE SPECIMEN HOLDER
    4.
    发明公开
    TISSUE SPECIMEN HOLDER 有权
    持有人的组织样本

    公开(公告)号：EP1161702A1

    公开(公告)日：2001-12-12

    申请号：EP00907306.5

    申请日：2000-02-17

    申请人： LUCID, INC.

    发明人： GREENWALD, Roger, J. ,  ZAVISLAN, James, M.

    IPC分类号： G02B21/34

    CPC分类号： G01N21/0303 ,  B01L3/508 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0822 ,  B01L2400/0683 ,  G01N1/36 ,  G01N2021/0339 ,  G01N2021/0342 ,  G01N2021/0364 ,  G02B21/0028 ,  G02B21/34

    摘要： A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. An objective lens of the confocal imaging system receives and supports the plate, preferably by a magnetic coupling ring around the plate which is magnetically attached to the barrel of the objective lens. The lens may be fixed and a mechanism for positioning the tray with respect to the lens in a direction along the optical axis of the lens and in orthogonal directions perpendicular to that axis shares a common support with the lens. Wavefront distortion which may result from an effectively corrugated surface of the specimen is minimized by selecting an immersion liquid which equals the refractive index of the near surface tissues. The tissue determines the index of the immersion fluid. The thicknesses and refractive indices of the window and plate are then determined to correct the residual aberration of the optical system. Different trays having different window and plate thicknesses and indices may be provided for different specimen species such as kidney, liver, cervix, et cetera. Thus, a generic confocal imaging system with a generic objective lens is corrected for image aberration and wavefront distortion due to the surface corrugations of the tissue. The correction is simplified since the bag is compliant and compresses so that the optical thickness along the axis between the objective lens and the focal plane in or at the specimen is substantially invariant whether the beam is focused at the interface between the specimen and the window or within the specimen over a focusing range which can extend over several millimeters.

    CONFOCAL MICROSCOPE FOR FACILITATING CRYOSURGERY OF TISSUE
    5.
    发明公开
    CONFOCAL MICROSCOPE FOR FACILITATING CRYOSURGERY OF TISSUE 审中-公开
    共聚焦显微镜，以方便组织冷冻

    公开(公告)号：EP1066488A1

    公开(公告)日：2001-01-10

    申请号：EP99908424.7

    申请日：1999-02-24

    申请人： LUCID, INC.

    发明人： ZAVISLAN, James, M.

    IPC分类号： F25B19/00

    CPC分类号： G02B21/0056 ,  A61B18/02 ,  A61B90/20 ,  A61B2018/00041 ,  G01N1/42 ,  G02B21/0028 ,  G02B21/34

    摘要： A confocal microscope (10) is provided including a confocal imaging system (12) having an objective lens (13), and a device (20) which can be an attachment to the confocal imaging system. The device (20) has a housing (22) with an interior cavity (24), two opposite ends where one end of the housing receives the objective lens (13), and a chamber (26) at the other end of the housing (22). The chamber (26) has first, and second plates with opposing sides. The first plate (30) lies adjacent the tissue (21) to be treated, and the second plate (28) is attached to the housing (22). To freeze the tissue, the chamber (26) receives a cryogenic fluid, thereby there is cryosurgical treatment of the tissue below the chamber. The chamber has an input port (34) to receive the cryogenic fluid, and an output port (35) to vent the cryogenic fluid. The confocal microscope (10) can provide images of the tissue (21) before, during, and after cryosurgical treatment.

    SYSTEM FOR FACILITATING PATHOLOGICAL EXAMINATION OF A LESION IN TISSUE
    6.
    发明公开
    SYSTEM FOR FACILITATING PATHOLOGICAL EXAMINATION OF A LESION IN TISSUE 失效
    安排网络变化的病理检查

    公开(公告)号：EP1011421A1

    公开(公告)日：2000-06-28

    申请号：EP98906513.1

    申请日：1998-02-19

    申请人： LUCID, INC.

    发明人： ZAVISLAN, James, M.

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0066 ,  A61B5/0068 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3418 ,  G16H10/40 ,  G16H80/00 ,  Y10S128/92 ,  Y10S128/922

    摘要： In order to facilitate pathological examination of a lesion in in-vivo tissue, a system and method are provided having a computer system in which both a camera for producing a digital macroscopic picture of the lesion and an imager are coupled to the computer system. The imager is responsive to the computer system and has optics for scanning the lesion to generate images representing microscopic sections of the lesion which provide sufficient information for pathological examination of the lesion. The computer system generates location information, referencing the location in the macroscopic picture of the lesion where the lesion was scanned to the images, and stores data in an electronic file structure which contains at least a representation of the images, a representation of the macroscopic picture, and the location information. The file structure may then be sent to another computer system for viewing the images stored in the file structure to facilitate pathological examination of the lesion by persons trained to interpret such images, adding a diagnostic report about the lesion to the data of the file structure, and sending back the file structure to the computer system that originated it.

    SYSTEM FOR IMAGING MECHANICALLY STABILIZED TISSUE
    7.
    发明公开
    SYSTEM FOR IMAGING MECHANICALLY STABILIZED TISSUE 有权
    装置于成像机械稳定的组织

    公开(公告)号：EP1005288A1

    公开(公告)日：2000-06-07

    申请号：EP98940922.2

    申请日：1998-08-17

    申请人： LUCID, INC. ,  THE GENERAL HOSPITAL CORPORATION

    发明人： GREENWALD, Roger, J. ,  RAJADHYASKSHA, Milind

    IPC分类号： A61B5/00 ,  A61B5/05

    CPC分类号： G02B21/0012 ,  A61B10/0233 ,  G02B21/34

    摘要： A system (8) is provided having a clamping apparatus (10) with a first member (12) and a second member (14), which are spaced apart from each other. An attachment mechanism (20) is connected to the first member (12) for attaching the apparatus (10) to a confocal imaging system (22). This attachment mechanism (20) has a surface with a window facing the tissue to be examined. Opposing this surface is a third member (40) connected to the second member (14). A clamping mechanism includes the first member (12) and the second member (14) for clamping the tissue between the surface of the attachment mechanism (20) and the surface of the third member (40), thereby stabilizing the tissue to the confocal imaging system (22). The window (32) of the attachment mechanism (20) presents the clamped tissue to the confocal imaging system (22).