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公开(公告)号：EP1161702A1
公开(公告)日：2001-12-12
申请号：EP00907306.5
申请日：2000-02-17
申请人： LUCID, INC.
IPC分类号： G02B21/34
CPC分类号： G01N21/0303 , B01L3/508 , B01L2300/043 , B01L2300/0609 , B01L2300/0654 , B01L2300/0672 , B01L2300/0822 , B01L2400/0683 , G01N1/36 , G01N2021/0339 , G01N2021/0342 , G01N2021/0364 , G02B21/0028 , G02B21/34
摘要： A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. An objective lens of the confocal imaging system receives and supports the plate, preferably by a magnetic coupling ring around the plate which is magnetically attached to the barrel of the objective lens. The lens may be fixed and a mechanism for positioning the tray with respect to the lens in a direction along the optical axis of the lens and in orthogonal directions perpendicular to that axis shares a common support with the lens. Wavefront distortion which may result from an effectively corrugated surface of the specimen is minimized by selecting an immersion liquid which equals the refractive index of the near surface tissues. The tissue determines the index of the immersion fluid. The thicknesses and refractive indices of the window and plate are then determined to correct the residual aberration of the optical system. Different trays having different window and plate thicknesses and indices may be provided for different specimen species such as kidney, liver, cervix, et cetera. Thus, a generic confocal imaging system with a generic objective lens is corrected for image aberration and wavefront distortion due to the surface corrugations of the tissue. The correction is simplified since the bag is compliant and compresses so that the optical thickness along the axis between the objective lens and the focal plane in or at the specimen is substantially invariant whether the beam is focused at the interface between the specimen and the window or within the specimen over a focusing range which can extend over several millimeters.
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公开(公告)号：EP1066488A1
公开(公告)日：2001-01-10
申请号：EP99908424.7
申请日：1999-02-24
申请人： LUCID, INC.
发明人： ZAVISLAN, James, M.
IPC分类号： F25B19/00
CPC分类号： G02B21/0056 , A61B18/02 , A61B90/20 , A61B2018/00041 , G01N1/42 , G02B21/0028 , G02B21/34
摘要： A confocal microscope (10) is provided including a confocal imaging system (12) having an objective lens (13), and a device (20) which can be an attachment to the confocal imaging system. The device (20) has a housing (22) with an interior cavity (24), two opposite ends where one end of the housing receives the objective lens (13), and a chamber (26) at the other end of the housing (22). The chamber (26) has first, and second plates with opposing sides. The first plate (30) lies adjacent the tissue (21) to be treated, and the second plate (28) is attached to the housing (22). To freeze the tissue, the chamber (26) receives a cryogenic fluid, thereby there is cryosurgical treatment of the tissue below the chamber. The chamber has an input port (34) to receive the cryogenic fluid, and an output port (35) to vent the cryogenic fluid. The confocal microscope (10) can provide images of the tissue (21) before, during, and after cryosurgical treatment.
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公开(公告)号：EP1011421A1
公开(公告)日：2000-06-28
申请号：EP98906513.1
申请日：1998-02-19
申请人： LUCID, INC.
发明人： ZAVISLAN, James, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , A61B5/0068 , G06F19/00 , G06F19/321 , G06F19/3418 , G16H10/40 , G16H80/00 , Y10S128/92 , Y10S128/922
摘要： In order to facilitate pathological examination of a lesion in in-vivo tissue, a system and method are provided having a computer system in which both a camera for producing a digital macroscopic picture of the lesion and an imager are coupled to the computer system. The imager is responsive to the computer system and has optics for scanning the lesion to generate images representing microscopic sections of the lesion which provide sufficient information for pathological examination of the lesion. The computer system generates location information, referencing the location in the macroscopic picture of the lesion where the lesion was scanned to the images, and stores data in an electronic file structure which contains at least a representation of the images, a representation of the macroscopic picture, and the location information. The file structure may then be sent to another computer system for viewing the images stored in the file structure to facilitate pathological examination of the lesion by persons trained to interpret such images, adding a diagnostic report about the lesion to the data of the file structure, and sending back the file structure to the computer system that originated it.
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公开(公告)号：EP1011421B1
公开(公告)日：2014-05-14
申请号：EP98906513.1
申请日：1998-02-19
申请人： LUCID, INC.
发明人： ZAVISLAN, James, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , A61B5/0068 , G06F19/00 , G06F19/321 , G06F19/3418 , G16H10/40 , G16H80/00 , Y10S128/92 , Y10S128/922
摘要： In order to facilitate pathological examination of a lesion in in-vivo tissue, a system and method are provided having a computer system in which both a camera for producing a digital macroscopic picture of the lesion and an imager are coupled to the computer system. The imager is responsive to the computer system and has optics for scanning the lesion to generate images representing microscopic sections of the lesion which provide sufficient information for pathological examination of the lesion. The computer system generates location information, referencing the location in the macroscopic picture of the lesion where the lesion was scanned to the images, and stores data in an electronic file structure which contains at least a representation of the images, a representation of the macroscopic picture, and the location information. The file structure may then be sent to another computer system for viewing the images stored in the file structure to facilitate pathological examination of the lesion by persons trained to interpret such images, adding a diagnostic report about the lesion to the data of the file structure, and sending back the file structure to the computer system that originated it.
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公开(公告)号：EP1003429B1
公开(公告)日：2008-09-24
申请号：EP98911824.5
申请日：1998-03-19
申请人： LUCID, INC.
IPC分类号： A61B18/00
CPC分类号： G02B26/12 , A61B18/20 , A61B18/203 , A61B90/20 , A61B2018/00452 , A61B2018/00636 , A61B2562/0242 , G02B21/0012 , G02B21/0028
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6.发明公开
公开(公告)号：EP1247246A1
公开(公告)日：2002-10-09
申请号：EP00977080.1
申请日：2000-11-10
申请人： LUCID, INC.
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G02B21/367 , G06T3/4038 , G06T2207/10056 , G06T2207/20021 , G06T2207/30024
摘要： A map (MAP) is created from digital images, of an excised tissue specimen (20), obtained by confocal reflectance light microscopy (10) so that the orientation of the excised specimen and the location of tissue regions of interest, for example showing basal and squamous cell cancers for use in Moh's surgery can be indicated to the surgeon for use in the extirpation of the undesirable cells, such as malignancies. Images of slices (34) through the excised specimen can be obtained by confocal microscopy to obtain confocal maps which show the histopathology of the excision from a single excision, and without the need for slicing the excised specimen into sections for sectioning, dyeing, and coding of the regions of interest on an anatomic map, thereby reducing the time for detection of suspicious regions.
摘要翻译： 显示器（34）从切除的组织标本的数字图像提供组织和感兴趣区域（癌症）的取向和位置。 使用共聚焦显微镜（10）获得通过切除标本的切片的图像以获得共焦图，以提供各自对应于不同图元素的图像的马赛克。 提供显着地图元素的宏观图像和选定元素的高分辨率图像以定位和标记癌变区域，从而帮助外科医生切除这些区域。
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7.发明授权
公开(公告)号：EP1113749B1
公开(公告)日：2016-03-30
申请号：EP99946929.9
申请日：1999-09-13
申请人： LUCID, INC.
CPC分类号： A61B5/444 , A61B5/0066 , A61B5/0068 , G01N2001/282 , G02B21/34
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公开(公告)号：EP1121052A2
公开(公告)日：2001-08-08
申请号：EP99946898.6
申请日：1999-09-13
申请人： LUCID, INC.
CPC分类号： G02B21/0024 , A61B10/0096 , G01N1/36 , G02B21/34
摘要： In order to determine, rapidly and without the delay required by conventional tissue preparation techniques for pathological examination (freezing, sectioning, staining, etc.), whether, an excision, which may be a biopsy sample, is representative of the morphology of interest of whether an excisional biopsy in which the tissue taken completely removes the abnormality is, in either case, the tissue which is desired to be excisioned, the tissue specimen (18) in encapsulated, preferably as part of the biopsy procedure. The encapsulated tissue is contained in an optically transparent cassette (34). The cassette (34) or an endcap (38) enclosing the cassette is marked with a fiducial (40) indicating and corresponding to the location of the excision on the patient's body. An image, which is preferably a representation of a surface of the tissue specimen and the vertical section(s) area of the tissue internal of the specimen and adjacent to a surface thereof, is obtained by means of an electro-optical imaging system (10), preferably a confocal laser scanning microscope. The cassette is moved, preferably in a stage (22) which rotates the cassette while translating it, so that the head (12) of the confocal microscope (its objective lens) provides a linear scan in a direction perpendicular to the wall of the cassette (also perpendicular to the surface of the tissue encapsulated in the cassette). The display (28) from the microscope indicates the morphology at and in proximity to the surface of the specimen as well as the location thereof. The pathologist and the surgeon is thereby provided with information concerning the specimen and whether the entire abnormality desired to be removed has indeed been removed and/or whether the biopsy is representative of the body region of interest in the case of a biopsy sample.
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公开(公告)号：EP1121052B1
公开(公告)日：2018-07-25
申请号：EP99946898.6
申请日：1999-09-13
申请人： LUCID, INC.
CPC分类号： G02B21/0024 , A61B10/0096 , G01N1/36 , G02B21/34
摘要： Encapsulated tissue is contained in an optically transparent cassette (34). The cassette (34) or an endcap (38) enclosing the cassette is marked with a fiducial (40) indicating and corresponding to the location of the excision on the patient's body. An image, which is preferably a representation of a surface of the tissue specimen and the vertical section(s) area of the tissue internal of the specimen and adjacent to a surface thereof, is obtained by an imaging system (10). The cassette is moved, preferably in a stage (22) which rotates the cassette while translating it, so that the head (12) of the imaging system provides a linear scan in a direction perpendicular to the wall of the cassette (also perpendicular to the surface of the tissue encapsulated in the cassette). The imaging system's display (28) indicates the morphology at and in proximity to the surface of the specimen as well as the location thereof.
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10.发明授权
公开(公告)号：EP1002253B1
公开(公告)日：2008-02-20
申请号：EP97933239.2
申请日：1997-06-30
申请人： LUCID, INC.
IPC分类号： G02B21/00
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B2562/146
摘要： A handheld confocal imaging system for in vivo observation of dermal and subdermal tissue allows diagnosis of conditions substantially beneath the surface of the skin. A confocal head has optics which scan the tissue so as to provide images of vertical sections of the tissue. Both two and three dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
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