-
1.发明公开NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开硬脂酰辅酶AΔ9去饱和酶的新螺环化合物作为抑制剂
公开(公告)号：EP2459568A4
公开(公告)日：2013-02-27
申请号：EP10803769
申请日：2010-07-21
IPC分类号： C07D491/107 , A61K31/438 , A61P3/00
CPC分类号： C07D491/107
-
公开(公告)号：EP2344497A4
公开(公告)日：2012-05-30
申请号：EP09813946
申请日：2009-09-17
IPC分类号： C07D471/14 , A61K31/4375
CPC分类号： C07D471/14
-
公开(公告)号：EP2346865A1
公开(公告)日：2011-07-27
申请号：EP09813945.4
申请日：2009-09-17
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.
-
公开(公告)号：EP2307334A1
公开(公告)日：2011-04-13
申请号：EP09770842.4
申请日：2009-06-22
摘要： The instant invention involves the enantioselective hydrogenation of isomeric N-H imines (N-unsubstituted) using a transition metal based catalyst modified with a chiral phosphine derivative to produce enantiomerically enriched chiral amines.
-
5.发明公开BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开双环杂芳族化合物作为抑制剂硬脂酰辅酶A DELTA-9脱氢酶
公开(公告)号：EP2152719A4
公开(公告)日：2011-01-19
申请号：EP08748339
申请日：2008-05-22
发明人： LEGER SERGE , DESCHENES DENIS , FORTIN REJEAN , ISABEL ELISE , POWELL DAVID
IPC分类号： C07D513/04 , A61K31/519 , A61K31/522 , A61P3/00 , C07D473/30 , C07D498/04
CPC分类号： C07D513/04
-
6.发明公开HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开杂芳族化合物AS硬脂酰 - 辅酶A-Δ9去饱和酶的抑制剂
公开(公告)号：EP1966183A4
公开(公告)日：2010-12-29
申请号：EP06840480
申请日：2006-12-18
IPC分类号： C07D401/04 , A61K31/501 , A61P3/00 , A61P9/10 , A61P35/00 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/14 , C07D471/04
-
公开(公告)号：EP2013169A4
公开(公告)日：2010-12-01
申请号：EP07719615
申请日：2007-04-23
发明人： BOYD MICHAEL , COLUCCI JOHN , WANG ZHAOYIN
IPC分类号： C07D209/08 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/4192 , C07D209/12 , C07D209/30 , C07D231/56 , C07D235/06 , C07D249/18
CPC分类号： C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D231/56 , C07D235/06 , C07D249/18
-
公开(公告)号：EP1841730A4
公开(公告)日：2010-10-27
申请号：EP06701742
申请日：2006-01-17
IPC分类号： C07C255/29 , A61K31/00 , A61K31/165 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/4965 , A61K45/06 , A61P9/00 , A61P9/10 , C07D211/34 , C07D241/12
CPC分类号： A61K31/00 , A61K31/165 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/4965 , A61K45/06 , C07C255/29 , A61K2300/00
-
9.发明公开2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO(9,10-D)IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H-菲并（9,10-D）咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1954683A4
公开(公告)日：2010-10-06
申请号：EP06817652
申请日：2006-11-21
发明人： CHAU ANH , COTE BERNARD , DUCHARME YVES , FRENETTE RICHARD , FRIESEN RICHARD , GAGNON MARC , GIROUX ANDRE , MARTINS EVELYN , YU HONGPING , WU TOM
IPC分类号： C07D235/02 , A61K31/4184 , C07D401/04 , C07D401/06 , C07D405/06 , C07D413/06
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
-
公开(公告)号：EP2225196A1
公开(公告)日：2010-09-08
申请号：EP08853988.7
申请日：2008-11-26
IPC分类号： C07C31/32 , A61K31/277 , A61P33/00 , C07C255/60 , C07C323/29 , C07D207/335 , C07D213/38 , C07D213/57 , C07D213/89 , C07D271/06 , C07D295/135 , C07D295/185
CPC分类号： C07C255/60 , A61K31/277 , A61K31/4418 , A61K31/5375 , A61K45/06 , C07C255/44 , C07C255/46 , C07C311/37 , C07C317/32 , C07C323/32 , C07C2601/02 , C07D207/335 , C07D213/36 , C07D213/38 , C07D213/57 , C07D213/89 , C07D271/06 , C07D295/135 , C07D295/185 , C07D295/192 , Y02A50/486
摘要： Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, strongyloidiasis, trichostrongyliasis, trichomoniasis or cestodiasis. Compounds of formula I of the invention are capable of treating and/or preventing the above-identified diseases:
-
-
-
-
-
-
-
-
-
搜索结果
172 条记录 (耗时 0.019 秒)
