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1.发明公开NOVEL DIHYDROPYRIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS AND NEUROKININ-3 RECEPTOR ANTAGONISTS 有权新型二氢吡啶-2（1H） - 酮化合物作为S-亚硝基谷胱甘肽还原酶，和神经激肽-3受体拮抗剂
公开(公告)号：EP2592934A4
公开(公告)日：2014-01-22
申请号：EP11807317
申请日：2011-07-08
发明人： SUN XICHENG , QIU JIAN
IPC分类号： A61K31/715 , C07D211/88 , C07D213/22 , C07D401/04 , C07D409/04 , C07D409/14
CPC分类号： A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , C07D211/86 , C07D211/88 , C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14
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公开(公告)号：EP2533637B1
公开(公告)日：2014-03-26
申请号：EP10845917.3
申请日：2010-02-12
发明人： SUN, Xicheng , QIU, Jian , WASLEY, Jan
IPC分类号： C07D311/36 , A61K31/352 , A61P11/00 , A61P11/06 , A61P9/00 , A61P9/12
CPC分类号： A61K31/352 , A61K31/381 , C07D311/34 , C07D311/36 , C07D409/04
摘要： The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
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3.发明公开NOVEL DIHYDROPYRIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS AND NEUROKININ-3 RECEPTOR ANTAGONISTS 有权新型二氢吡啶-2（1H） - 酮化合物作为S-亚硝基谷胱甘肽还原酶，和神经激肽-3受体拮抗剂
公开(公告)号：EP2592934A1
公开(公告)日：2013-05-22
申请号：EP11807317.0
申请日：2011-07-08
发明人： SUN, Xicheng , QIU, Jian
IPC分类号： A01N57/00 , A61K31/715 , C07D213/22
CPC分类号： A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , C07D211/86 , C07D211/88 , C07D401/04 , C07D401/14 , C07D409/04 , C07D409/14
摘要： The present invention is directed to novel dihydropyridin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors and/or Neurokinin-3 (NK3) receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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4.发明授权NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS 有权新型PYRROLHEMMER的S-亚硝基还原酶作为治疗剂
公开(公告)号：EP2318007B1
公开(公告)日：2013-01-23
申请号：EP09807379.4
申请日：2009-08-14
发明人： WASLEY, Jan , ROSENTHAL, Gary, J. , SUN, Xicheng , STRONG, Sarah , QIU, Jian
IPC分类号： C07D403/06 , C07D403/14 , C07D409/14 , A61K31/535 , A61P35/00
CPC分类号： C07D409/14 , C07D403/06 , C07D403/14
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5.发明公开NOVEL SUBSTITUTED QUINOLINE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 有权新的取代喹啉化合物S-亚硝基还原酶
公开(公告)号：EP2624695A4
公开(公告)日：2014-07-30
申请号：EP11831651
申请日：2011-10-07
发明人： SUN XICHENG , QIU JIAN , STOUT ADAM
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4706 , A61K31/4709 , C07D215/00 , C07D215/42 , C07D215/46 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10
摘要： The present application is directed towards methods of preparing novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors.
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6.发明公开NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开新的取代双环芳族化合物，S-亚硝基还原酶
公开(公告)号：EP2651223A1
公开(公告)日：2013-10-23
申请号：EP11849278.4
申请日：2011-12-16
发明人： SUN, Xicheng , QIU, Jian , STOUT, Adam
IPC分类号： A01N43/42
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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公开(公告)号：EP2512247A4
公开(公告)日：2013-05-22
申请号：EP10838203
申请日：2010-12-14
发明人： SUN XICHENG
IPC分类号： C07D333/24 , A61K31/381 , A61P29/00 , C07D409/10 , C07D409/14
CPC分类号： C07D333/24 , C07D409/10 , C07D409/14
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公开(公告)号：EP2533638A1
公开(公告)日：2012-12-19
申请号：EP11742796.3
申请日：2011-02-10
发明人： SUN, Xicheng , QIU, Jian
IPC分类号： A01N43/16
CPC分类号： A61K31/433 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/41 , A61K31/4245 , C07D311/22 , C07D311/36 , C07D311/58 , C07D335/06 , C07D405/10 , C07D407/08 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
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9.发明公开NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开新型取代的双环芳香化合物作为S-硝基葡萄糖糖醛酸还原酶抑制剂
公开(公告)号：EP2651871A1
公开(公告)日：2013-10-23
申请号：EP11849550.6
申请日：2011-12-16
发明人： SUN, Xicheng , QIU, Jian , STOUT, Adam
IPC分类号： C07C63/36
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
摘要翻译： 本发明涉及可用作S-亚硝基谷胱甘肽还原酶（GSNOR）抑制剂的新的取代的双环芳族化合物，包含此类化合物的药物组合物，以及制备和使用它们的方法。
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10.发明公开NOVEL SUBSTITUTED QUINOLINE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 有权新的取代喹啉化合物S-亚硝基还原酶
公开(公告)号：EP2624695A1
公开(公告)日：2013-08-14
申请号：EP11831651.2
申请日：2011-10-07
发明人： SUN, Xicheng , QIU, Jian , STOUT, Adam
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4706 , A61K31/4709 , C07D215/00 , C07D215/42 , C07D215/46 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10
摘要： The present application is directed towards methods of preparing novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors.
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