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公开(公告)号：EP0797450A4
公开(公告)日：2000-02-02
申请号：EP95942479
申请日：1995-11-27
发明人： SCADDEN DAVID T , FREEDMAN ANDREW
IPC分类号： G01N33/49 , A61K35/12 , A61K35/14 , A61K35/28 , A61K38/20 , C12N5/0783 , G01N33/543 , A61K45/05 , A01N63/00 , C12N5/00
CPC分类号： C12N5/0636 , A61K35/17 , C12N2501/23 , C12N2501/26 , C12N2502/11 , C12N2503/00 , G01N33/505
摘要： The present invention provides an in vitro T-lymphopoiesis system in which a population of T-cells is produced from precursor cells expressing CD34. The T-lymphopoiesis system of the present invention produces a population of T-cells of which approximately 17-74% express CD2, approximately 1.5-34% express CD3, and approximately 16-61% express CD4, and approximately 0-15% express CD8. A method of producing such a population of T-cells in vitro, as well as various compositions including T-cells of the present invention, are also provided.
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公开(公告)号：EP0751959B1
公开(公告)日：2000-01-05
申请号：EP95912917.2
申请日：1995-03-15
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , A61K38/00 , Y10S514/814
摘要： Modified polypeptides with increased biological activity exhibited as either increased potency or prolonged circulating half-life are disclosed with methods of preparing the modified polypeptides and methods of use.
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3.发明公开ANTI-INFLAMMATORY AND INFECTION PROTECTIVE EFFECTS OF SESAMIN-BASED LIGNANS 失效ANTIFLAMMATORISCHE之前感染保护作用的木酚素SESAMINBASIS
公开(公告)号：EP0873116A1
公开(公告)日：1998-10-28
申请号：EP95911881.0
申请日：1995-02-22
CPC分类号： A61K36/185 , A61K36/30 , A61K36/31 , Y10S514/885 , A61K2300/00
摘要： The uses of lignans of the sesamin family to treat infection and inflammation is disclosed. These lignans may be delivered enterally or parenterally and either in the form of sesame oil or in purified form. A total parenteral nutrition solution or dietary supplement are the preferred forms of administration.
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公开(公告)号：EP0714435A4
公开(公告)日：1997-08-20
申请号：EP94922037
申请日：1994-06-28
发明人： LIU JIAN-NING , GUREWICH VICTOR
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P7/02 , C07K14/745 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/72 , C12N15/57 , C12R1/91 , C12N9/48 , A61K38/48 , C12N15/58
CPC分类号： C12Y304/21073 , A61K38/00 , C12N9/6459 , C12N9/6462 , C12Y304/21069
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公开(公告)号：EP0600860A1
公开(公告)日：1994-06-15
申请号：EP91904209.0
申请日：1991-02-08
发明人： STUART, Regina, K. , LOWELL, Jeffrey, A. , BAXTER, John, K., III , BISTRIAN, Bruce, R. , SHIKORA, Scott
IPC分类号： A61M25
CPC分类号： A61M25/01 , A61M25/0014 , A61M25/0169 , A61M25/09 , A61M2025/0008
摘要： Appareil et procédés de cathétérisme veineux central initial ou de remplacement, utilisant un fil de guidage souple (12) sur lequel se trouvent des marques (16), ainsi qu'un cathéter non thrombogène sensiblement translucide (10). Lors de l'utilisation, on insère le fil de guidage le long d'un cathéter (40) positionné dans une veine (42). Ensuite, on utilise les marques se trouvant sur le fil de guidage afin d'établir et de maintenir constante la position du fil de guidage. On retire le cathéter se trouvant déjà dans la veine en le faisant glisser sur le fil de guidage, puis on fait glisser un nouveau cathéter (50) sur le fil de guidage jusqu'en position. Une fois le nouveau cathéter positionné on retire le fil de guidage.
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公开(公告)号：EP0587777A1
公开(公告)日：1994-03-23
申请号：EP92913689.0
申请日：1992-05-22
CPC分类号： C07K16/30 , A61K38/00 , C07K14/47 , C07K14/705
摘要： L'invention concerne des protéines, ou des fragments de celles-ci, liant spécifiquement un antigène carcinoembryonnaire (CEA) en présence d'un cation divalent in vitro. L'invention concerne également des procédés d'isolation de ces protéines ou d'autres protéines liant le CEA. Ce procédé consiste à obtenir un échantillon biologique contenant un CEA et une protéine de liaison de CEA (CBP), et à le mettre en contact avec un cation divalent, à une concentration donnée et pendant une durée suffisante pour permettre la liaison dudit CBP au CEA, formant ainsi un conjugué CBP-CEA. On met ensuite en contact l'échantillon avec un adsorbant liant le CEA, pendant une durée suffisante pour permettre l'adsorption du conjugué dans l'adsorbant. Les éventuelles parties de l'échantillon non adsorbé par l'adsorbant sont éliminées. Le CBP est dissocié du conjugué lié à l'adsorbant, et il est collecté.
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公开(公告)号：EP0512076A4
公开(公告)日：1993-03-03
申请号：EP91904991
申请日：1991-01-23
发明人： BISTRIAN, BRUCE, R.
CPC分类号： A61K31/23
摘要： Disclosed is a method of treating cancer using nutritional support therapy by administration of a structured lipid containing both φ3 fatty acids and medium-chain fatty acids. The therapy may be used as total parental nutrition or as a nutritional supplement. The addition of tumor necrosis factor may also be beneficial.
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公开(公告)号：EP0412115A4
公开(公告)日：1991-11-13
申请号：EP89905845
申请日：1989-04-25
CPC分类号： C07K14/745 , A61K38/00
摘要： A new class of hybrid peptides having domains which are analogues of receptor interaction sites on an adhesive protein have been developed. These hybrid peptides are useful in methods of inhibiting aggregation of platelets and adhesion of platelet and fibrin thrombi to vessel walls. Methods of producing synthetic substitutes for fibrinogen, von Willebrand factor and other adhesive proteins are also disclosed.
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公开(公告)号：EP0428569A1
公开(公告)日：1991-05-29
申请号：EP89908789.0
申请日：1989-08-02
发明人： ITO, Ralph, K. , LOGERFO, Frank, W.
CPC分类号： A61L33/0047 , A61F2/06 , A61L33/0029
摘要： Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and the thrombogenesis inhibitor thrombomodulin immobilized on the base coat layer via a component capable of binding the inhibitor without affecting its thrombogenesis-inhibiting activity.
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