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    ANTI-MUSCARINIC AGENT AND ESTROGEN-AGONIST FOR TREATING UNSTABLE OR OVERACTIVE BLADDER
    2.
    发明公开
    ANTI-MUSCARINIC AGENT AND ESTROGEN-AGONIST FOR TREATING UNSTABLE OR OVERACTIVE BLADDER 审中-公开
    ANTI-MUSCARINISCHES剂雌激素活性的不稳定或泡泡的治疗

    公开(公告)号：EP1441707A1

    公开(公告)日：2004-08-04

    申请号：EP02783937.2

    申请日：2002-11-07

    申请人： Pharmacia AB

    发明人： VERSI, Ebrahim

    IPC分类号： A61K31/135 ,  A61K31/565 ,  A61P13/10

    CPC分类号： A61K31/135 ,  A61K9/0034 ,  A61K31/137 ,  A61K31/565 ,  A61K31/568 ,  A61K2300/00

    摘要： The invention relates to a method of treating unstable or overactive urinary bladder, wherein the method comprises administering to a patient in need of such treatment an antimuscarinic agent in a pharmaceutically effective amount thereof and ostrogen agonist in a pharmaceutically effective amount thereof. The antimuscarinic agent is preferebly tolterodine or a tolterodine-related compound. The invention also relates to a pharmaceutical formation containing an antimuscarinic agent, estrogen agonist and pharmaceutically excipients and the use of the combination for the manufacture of a therapeutical formulation for treating unstable or overactive urinary bladder.

    GENE ENCODING PROTEIN CLUSTER I AND THE ENCODED PROTEIN
    3.
    发明公开
    GENE ENCODING PROTEIN CLUSTER I AND THE ENCODED PROTEIN 审中-公开
    GEN，对蛋白质CLUSTER 1编码和编码蛋白

    公开(公告)号：EP1335934A1

    公开(公告)日：2003-08-20

    申请号：EP01997502.8

    申请日：2001-11-22

    申请人： Pharmacia AB

    发明人： ATTERSAND, Anneli

    IPC分类号： C07K14/00

    CPC分类号： C07K14/47

    摘要： The present invention relates to the identifcation of a human gene family expressed in metabolically relevant tissues. The genes encode a group polypeptides referred to as 'Protein Cluster I' which are predicted to be useful in the diagnosis of metabolic diseases, such as obesity and diabetes, as well as in the identification of agents useful in the treatment of the said diseases.

    PROCESS OF PREPARING TOLTERODINE AND ANALOGUES THERE OF AS WELL AS INTERMEDIATES PREPARED IN THE PROCESS
    5.
    发明公开
    PROCESS OF PREPARING TOLTERODINE AND ANALOGUES THERE OF AS WELL AS INTERMEDIATES PREPARED IN THE PROCESS 有权
    用于托特罗定生产及其类似物和在生产的产品之间的过程

    公开(公告)号：EP1242361A1

    公开(公告)日：2002-09-25

    申请号：EP00990151.3

    申请日：2000-12-22

    申请人： Pharmacia AB

    发明人： ANDERSSON, Pehr, G. ,  HEDBERG, Christian

    IPC分类号： C07C213/02 ,  C07C215/54 ,  C07C217/62 ,  C07C49/683 ,  C07C49/67 ,  C07C49/223 ,  C07C35/32 ,  C07D311/20

    CPC分类号： C07D311/20 ,  C07B2200/07 ,  C07C29/143 ,  C07C35/32 ,  C07C45/512 ,  C07C45/65 ,  C07C45/74 ,  C07C49/835 ,  C07C213/00 ,  C07C213/02 ,  C07C215/54 ,  C07C2602/08 ,  C07C49/67 ,  C07C49/813

    摘要： The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprising the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II), wherein R1, R2, and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb); b) subjecting the compound of formula (IIIa) or (IIIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb); c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of formula (Va) or (Vb); d) converting the compound of formula (Va) or (Vb) to form the corresponding enantiomerically enriched compound of tolterodine or analogue thereof; and e) optionally converting a compound obtained in base form to a salt thereof, or converting a salt form to the free base. Formulas (IIIa), (IIIb), (IVa), (IVb), (Va) and (Vb) are specified in the application. The invention also relates to novel starting materials and intermediates used in the process.

    摘要翻译： 本发明提供了通式（Ia）或化合物的对映选择性制备方法（Ib）中： worin R1，R2和R3的海誓山盟unabhängig是氢，甲基，甲氧基，羟基，羟甲基，氨基甲酰基， 海誓山盟的磺酰基或卤素，且R 4和R 5是unabhängigC 1-6烷基，或其盐，该方法包括以下工艺步骤：D）将式（Va）或（Vb）中的化合物： worin R1 ，R2和R3如上所定义，以形成式I的对映体富集相应的化合物（Ia）或（Ib）中; 和e）式（Ia）或（Ib）的化合物和任选转化成它们的盐。

    LIQUID DELIVERY CONTAINER
    6.
    发明公开
    LIQUID DELIVERY CONTAINER 审中-公开
    ISSUE容器液体

    公开(公告)号：EP1207925A1

    公开(公告)日：2002-05-29

    申请号：EP00948481.7

    申请日：2000-07-20

    申请人： Pharmacia AB

    发明人： BENNWIK, Percy ,  TÖRNSTEN, Jonas

    IPC分类号： A61M11/00 ,  A61F9/00 ,  B05B9/08 ,  B65D83/00

    CPC分类号： A61M15/0045 ,  A61F9/0008 ,  A61M11/06 ,  A61M15/0043 ,  A61M15/0048

    摘要： Pressurisable container for storing and ejecting liquid, the container comprising a) a front wall having or surrounding a cavity corresponding to the form of an open vessel, b) an opening in the front wall adapted for ejection of the liquid from the container, said opening defining a container axis, c) optionally a sealing over the opening adapted for temporary use, and d) a rear wall closing and sealing the open part of the front wall vessel to confine a space for the liquid in the container, the rear wall running at least partially perpendicular to the container axis and being displaceable or deformable for movement towards the opening to pressurize the container liquid. The front wall is substantially rigid in relation to the rear wall, the rear wall before pressurizing the container is substantially flat or substantially single-curved and the rear wall is deformable under stretching to substantially fill out the container cavity. The invention also relates to methods for container manufacture and devices and methods for ejecting liquid from the containers.

    DEVICE FOR DISPLACING A MEMBER IN A CONTAINER
    7.
    发明授权
    DEVICE FOR DISPLACING A MEMBER IN A CONTAINER 失效
    设备中，用于元素的容器中的调整

    公开(公告)号：EP0850078B1

    公开(公告)日：2002-04-24

    申请号：EP96929616.9

    申请日：1996-08-22

    申请人： Pharmacia AB

    发明人： LJUNGQUIST, Olle

    IPC分类号： A61M5/19 ,  A61M5/24

    CPC分类号： A61M5/315 ,  A61M5/284 ,  A61M5/31505 ,  A61M2005/3132

    摘要： A device for displacing a plunger (35), movably disposed in a container (23), e.g. a medical multi-chamber ampoule, which has at least one movable partition (29), sealingly isolating at least two substances to be mixed with each other, comprises a holder means (6) for releasable connection to the container (23), a screw actuator (4) engageable with the plunger (37) for displacing it in the container (23), the holder means (6) further having a female thread, engageable with the corresponding male thread of the screw actuator. The female thread is divided into at least two parts, which are movable between a first position, in which the parts of the female thread are not engageable with the screw actuator, and a second position, in which the parts of the female thread are engageable with the actuator. The holder means (8) has actuating means for moving the female thread parts between said first and second positions.

    METHOD FOR PURIFICATION OF PROTEINS
    8.
    发明公开
    METHOD FOR PURIFICATION OF PROTEINS 有权
    方法清洗蛋白

    公开(公告)号：EP1185551A1

    公开(公告)日：2002-03-13

    申请号：EP00944505.7

    申请日：2000-06-08

    申请人： Pharmacia AB

    发明人： WINGE, Stefan

    IPC分类号： C07K1/30 ,  C07K14/81 ,  A61K38/55

    CPC分类号： C07K14/8128 ,  A61K38/00

    摘要： The present invention relates to methods for purification of antithrombin-III (AT-III) by precipitation of impurities. The said methods comprise (a) adding, to a solution comprising antithrombin-III, a saccharide and citrate, in an amount sufficient for impurities to precipitate while antithrombin-III essentially remains in solution; (b) allowing impurities to precipitate; and (c) removing the precipitated impurities, thereby obtaining a solution comprising purified antithrombin-III. The invention also relates to pharmaceutical compositions, obtainable by the said methods, comprising purified antithrombin-III, as well as to reconstituted pharmaceutical compositions essentially free from visible particles.