公开(公告)号：EP1532573A1

公开(公告)日：2005-05-25

申请号：EP03790586.6

申请日：2003-08-22

Applicant: Perceptronix Medical Inc. ,  British Columbia Cancer Agency

Inventor： MACAULAY, Calum, E. ,  GARNER, David, M. ,  US-KRASOVEC, Marija ,  FLEZAR, Margareta ,  ZGANEC, Mario ,  LAVRENCAK, Jaka ,  PALCIC, Branko, M. ,  FERGUSON, Gary W. , 

IPC: G06K9/00 ,  G06F19/00

CPC classification number: G06T5/40 ,  G06K9/00147 ,  G06T5/008 ,  G06T7/0012 ,  G06T2207/30024

Abstract: Computer programs, systems and the like related to processing, segmenting and feature normalizing digital images. The images are of cells and the methods are useful for the detection of malignancy-associated changes (MAC) in cells, which can be used for the detection of cancer. The programs and methods detect cancer in one tissue by detecting MAC in another tissue, such as associated tissues or non-associated tissues. Examples of associated tissues include nipple aspirates or ductal washings to detect breast cancer, and sputum or bronchial lavage to detect lung cancer. Examples of non-associated tissues include buccal mucosa to detect lung or breast cancer.

公开(公告)号：EP1845837A4

公开(公告)日：2011-03-02

申请号：EP06704094

申请日：2006-01-20

Applicant: PERCEPTRONIX MEDICAL INC ,  BC CANCER AGENCY

Inventor： ZENG HAISHAN ,  FAWZY YASSER SHERIF

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/1459 ,  G01N21/47 ,  G01N21/64

CPC classification number: G01N21/474 ,  A61B1/043 ,  A61B1/2676 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0261 ,  A61B5/14542 ,  A61B5/1459 ,  G01J3/02 ,  G01J3/0243 ,  G01J3/0291 ,  G01N21/359 ,  G01N21/4795 ,  G01N2021/4742

公开(公告)号：EP1845837A1

公开(公告)日：2007-10-24

申请号：EP06704094.9

申请日：2006-01-20

Applicant: Perceptronix Medical Inc. ,  BC Cancer Agency

Inventor： Zeng, Haishan ,  Fawzy, Yasser Sherif

IPC: A61B5/00

CPC classification number: G01N21/474 ,  A61B1/043 ,  A61B1/2676 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0261 ,  A61B5/14542 ,  A61B5/1459 ,  G01J3/02 ,  G01J3/0243 ,  G01J3/0291 ,  G01N21/359 ,  G01N21/4795 ,  G01N2021/4742

Abstract: The present invention provides a new method and device for disease detection, more particularly cancer detection, from the analysis of diffuse reflectance spectra measured in vivo during endoscopic imaging. The measured diffuse reflectance spectra are analyzed using a specially developed light-transport model and numerical method to derive quantitative parameters related to tissue physiology and morphology. The method also corrects the effects of the specular reflection and the varying distance between endoscope tip and tissue surface on the clinical reflectance measurements. The model allows us to obtain the absorption coefficient (μa) and further to derive the tissue micro-vascular blood volume fraction and the tissue blood oxygen saturation parameters. It also allows us to obtain the scattering coefficients (μs and g) and further to derive the tissue micro-particles volume fraction and size distribution parameters.

公开(公告)号：EP1626652A2

公开(公告)日：2006-02-22

申请号：EP04731561.9

申请日：2004-05-07

Applicant: Perceptronix Medical Inc. ,  British Columbia Cancer Agency

Inventor： ZENG, Haishan ,  PETEK, Mirjan ,  PALCIC, Branko ,  FERGUSON, Gary, W.

IPC: A61B5/00

CPC classification number: A61B1/0676 ,  A61B1/043 ,  A61B1/0646 ,  A61B1/0684 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/4406 ,  G01J2003/1213

Abstract: The present invention comprises an optical apparatus, methods and uses for real-time (video-rate) multimodal imaging, for example, contemporaneous measurement of white light reflectance, native tissue autofluorescence and near infrared images with an endoscope. These principles may be applied to various optical apparati such as microscopes, endoscopes, telescopes, cameras etc. to view or analyze the interaction of light with objects such as planets, plants, rocks, animals, cells, tissue, proteins, DNA, semiconductors, etc. Multi-band spectral images may provide morphological data such as surface structure of lung tissue whereas chemical make-up, sub-structure and other object characteristics may be deduced from spectral signals related to reflectance or light radiated (emitted) from the object such as luminescence or fluorescence, indicating endogenous chemicals or exogenous substances such as dyes employed to enhance visualization, drugs, therapeutics or other agents. Accordingly, one embodiment of the present invention discusses simultaneous white light reflectance and fluorescence imaging. Another embodiment describes the addition of another reflectance imaging modality (in the near-IR spectrum). Input (illumination) spectrum, optical modulation, optical processing, object interaction, output spectrum, detector configurations, synchronization, image processing and display are discussed for various applications.

公开(公告)号：EP1535038A1

公开(公告)日：2005-06-01

申请号：EP03792067.5

申请日：2003-08-22

Applicant: Perceptronix Medical Inc.

Inventor： FERGUSON,, Gary, W. ,  US-KRASOVEC,, Marija ,  FLEZAR,, Margareta ,  ZGANEC,, Mario ,  LAVRENCAK,, Jaka ,  PALCIC,, Branko, M.

IPC: G01N1/28 ,  C12M1/12 ,  G01N15/02

CPC classification number: G01N1/18 ,  G01N1/2813 ,  G01N1/4077 ,  G01N15/0272 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The present invention provides a simple, inexpensive apparatus for and method of capturing biological or other material from sample suspensions on a collection surface and for depositing captured material on a receiving surface, such as a microscope slide, for observation and analysis. Accordingly, cytological material may be deposited in near mono-layers for the detection of disease. In one embodiement of the present invention, density gradients of material are captured and deposited, thus providing a desired range of concentrations for examination. In another embodiment multiple depositions or multiple slides may be made from the same sample suspension. The method and apparatus to exploit this new method are both presented for various applications. The dimensions of material captured and deposited may be controlled and used in conjunction with microscope slides that confine material to specific regions of interest.

公开(公告)号：EP1670348A4

公开(公告)日：2009-02-25

申请号：EP04786626

申请日：2004-09-15

Applicant: PERCEPTRONIX MEDICAL INC ,  BRITISH COLUMBIA CANCER AGENCY

Inventor： ZENG HAISHAN ,  PETEK MIRJAN ,  DAO JAMES ,  PALCIC BRANKO ,  FERGUSON GARY W

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  G01N21/64 ,  G06F19/00

CPC classification number: A61B1/00055 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

Abstract: The present invention is an automated endoscopic device and diagnostic method, which performs at least one other disease detection method simultaneously during a white light endoscopic procedure. In some embodiments fluorescence imaging or spectroscopy is performed during the white light examination. In other embodiments, multi-modal imaging and/or spectroscopy may be performed and combined in a variety of ways. Because diagnostic modes other than white light are performed transparently in the background, the procedure is not significantly more complex for the clinician than the familiar white light examination. In some embodiments the present invention automatically detects suspicious tissue and informs the clinician of its presence. In other embodiments the present invention helps determine if a biopsy is required, and may further assist the clinician, for example, by providing an outline or otherwise guide the clinician in identifying and/or taking a biopsy of a suspicious site. In yet other embodiments, the present invention includes refinements afforded by incorporating a priori information, for example, patient history, previous endoscopy data, the results of qualitative and/or quantitative sputum cytology etc.

公开(公告)号：EP1532573B1

公开(公告)日：2008-10-15

申请号：EP03790586.6

申请日：2003-08-22

Applicant: Perceptronix Medical Inc. ,  British Columbia Cancer Agency

Inventor： MACAULAY, Calum, E. ,  GARNER, David, M. ,  US-KRASOVEC, Marija ,  FLEZAR, Margareta ,  ZGANEC, Mario ,  LAVRENCAK, Jaka ,  PALCIC, Branko, M. ,  FERGUSON, Gary W. , 

IPC: G06K9/00 ,  G06F19/00

CPC classification number: G06T5/40 ,  G06K9/00147 ,  G06T5/008 ,  G06T7/0012 ,  G06T2207/30024

Abstract: Computer programs, systems and the like related to processing, segmenting and feature normalizing digital images. The images are of cells and the methods are useful for the detection of malignancy-associated changes (MAC) in cells, which can be used for the detection of cancer. The programs and methods detect cancer in one tissue by detecting MAC in another tissue, such as associated tissues or non-associated tissues. Examples of associated tissues include nipple aspirates or ductal washings to detect breast cancer, and sputum or bronchial lavage to detect lung cancer. Examples of non-associated tissues include buccal mucosa to detect lung or breast cancer.

公开(公告)号：EP1670348A1

公开(公告)日：2006-06-21

申请号：EP04786626.4

申请日：2004-09-15

Applicant: Perceptronix Medical Inc. ,  British Columbia Cancer Agency

Inventor： ZENG, Haishan ,  PETEK, Mirjan ,  DAO, James ,  PALCIC, Branko ,  FERGUSON, Gary, W.

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  G06F19/00 ,  G01N21/64

CPC classification number: A61B1/00055 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

Abstract: The present invention is an automated endoscopic device and diagnostic method, which performs at least one other disease detection method simultaneously during a white light endoscopic procedure. In some embodiments fluorescence imaging or spectroscopy is performed during the white light examination. In other embodiments, multi-modal imaging and/or spectroscopy may be performed and combined in a variety of ways. Because diagnostic modes other than white light are performed transparently in the background, the procedure is not significantly more complex for the clinician than the familiar white light examination. In some embodiments the present invention automatically detects suspicious tissue and informs the clinician of its presence. In other embodiments the present invention helps determine if a biopsy is required, and may further assist the clinician, for example, by providing an outline or otherwise guide the clinician in identifying and/or taking a biopsy of a suspicious site. In yet other embodiments, the present invention includes refinements afforded by incorporating a priori information, for example, patient history, previous endoscopy data, the results of qualitative and/or quantitative sputum cytology etc.