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    FRUIT EXTRACTS
    2.
    发明公开
    FRUIT EXTRACTS 审中-公开
    水果提取物

    公开(公告)号：EP3173088A3

    公开(公告)日：2017-08-23

    申请号：EP16020502.7

    申请日：2009-11-02

    申请人： Provexis Natural Products Limited

    发明人： O'Kennedy, Niamh

    IPC分类号： A61K36/81

    摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.

    摘要翻译： 提供制备茄果科水果提取物的方法，其中加工水果以优化提取物的血小板聚集抑制活性。 这些方法涉及制备匀化水果的初始混合物; 从水果固体中分离水溶性部分; 过滤水溶性部分; 活性剂在过滤渗透液中的浓度本发明还提供了通过这种方法制备的水果提取物，以及含有糖基化酚酸或酚酯或其衍生物的水果提取物; 糖基化类黄酮; 和一个核苷。 本发明的提取物可用作治疗或预防以不适当的血小板聚集为特征的医学症状的药物。 特别地，药物可用于通过减少血小板聚集维持心脏健康; 有利于流通; 和/或正常化或以其他方式有益于血流。

    FRUIT EXTRACTS
    3.
    发明公开
    FRUIT EXTRACTS 审中-公开

    公开(公告)号：EP4218783A1

    公开(公告)日：2023-08-02

    申请号：EP23167298.1

    申请日：2009-11-02

    申请人： Provexis Natural Products Limited

    发明人： O'Kennedy, Niamh

    IPC分类号： A61K36/81 ,  A61K31/7048 ,  A61K31/7064 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

    摘要： The present invention concerns food, food supplement and food additive compositions that comprise: (i) a substantially lycopene-free extract of fruit of the Solanaceae family wherein the extract comprises (a) a glycosylated phenolic acid or a phenolic ester, (b) a glycosylated flavonoid, and (c) a nucleoside; and wherein the extract is a powder and contains 95% of the bioactive components (a), (b) and (c) that are contained in a start mix from which the extract is prepared; and (ii) a nutritionally acceptable excipient or food ingredient. The compositions are useful in the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation.

    COMPOSITIONS
    4.
    发明公开
    COMPOSITIONS 审中-公开
    组合物

    公开(公告)号：EP2934560A1

    公开(公告)日：2015-10-28

    申请号：EP13815828.2

    申请日：2013-12-24

    申请人： Provexis Natural Products Limited

    发明人： O'KENNEDY, Niamh

    IPC分类号： A61K36/81 ,  A23L1/00

    摘要： The present invention relates to the use of a fruit extract and optionally other specific nutrients for preventing, reducing or minimising exercise-induced systemic inflammation and/or for promoting recovery from intense exercise. The invention also relates to compositions comprising such fruit extracts.

    摘要翻译： 本发明涉及水果提取物和任选的其他特定营养素用于预防，减少或最小化运动诱发的全身性炎症和/或促进强烈运动恢复的用途。 本发明还涉及包含这种水果提取物的组合物。

    FRUIT EXTRACTS
    9.
    发明公开
    FRUIT EXTRACTS 审中-公开
    OBSTEXTRAKTE

    公开(公告)号：EP3173088A2

    公开(公告)日：2017-05-31

    申请号：EP16020502.7

    申请日：2009-11-02

    申请人： Provexis Natural Products Limited

    发明人： O'Kennedy, Niamh

    IPC分类号： A61K36/81

    摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.

    摘要翻译： 提供了制作茄科的果实提取物的方法，其中加工水果以优化提取物的血小板聚集抑制活性。 该方法包括制备均质水果的起始混合物; 从水果固体中分离水溶性部分; 过滤水溶性部分; 和过滤渗透物中活性剂的浓度本发明还提供了通过这些方法制备的水果提取物，还提供了含有糖基化的酚酸或酚酯或其衍生物的果实提取物; 糖基化黄酮; 和核苷。 本发明的提取物可用作治疗或预防以血小板聚集不良为特征的医学病症的药物。 特别地，药物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血流正常化或以其他方式受益。