公开(公告)号：EP2310005A2

公开(公告)日：2011-04-20

申请号：EP09772776.2

申请日：2009-06-25

申请人： Provexis Natural Products Limited ,  Plant Bioscience Limited

发明人： O'KENNEDY, Niamh ,  MITHEN, Richard

IPC分类号： A61K31/26 ,  A61K45/06 ,  A61K36/31 ,  A61P1/00 ,  A61P19/02 ,  A61P29/00

CPC分类号： A61K31/26 ,  A23L2/02 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0095 ,  A61K36/31 ,  A61K36/87 ,  A61K45/06 ,  A23V2250/21 ,  A23V2250/21166 ,  A23V2200/324

摘要： The present invention concerns compositions that may be used in the prevention or treatment of medical conditions characterised by having an inflammatory component. The compositions comprise a therapeutically effective amount of an isothiocyanate (ITC). The composition may comprise further anti-inflammatory agents (e.g. plant- derived polyphenols).

公开(公告)号：EP2035027A1

公开(公告)日：2009-03-18

申请号：EP07733050.4

申请日：2007-06-01

申请人： Provexis Natural Products Limited

发明人： O'KENNEDY, Niamh ,  SONG, Hyun-Ju

IPC分类号： A61K36/81 ,  A61P7/02

CPC分类号： A61K36/81

摘要： The present invention relates to tomato extracts or an active fraction thereof for use in preventing or inhibiting the initiation of venous thrombosis and fibrin clot formation in a vein.

公开(公告)号：EP2934560A1

公开(公告)日：2015-10-28

申请号：EP13815828.2

申请日：2013-12-24

申请人： Provexis Natural Products Limited

发明人： O'KENNEDY, Niamh

IPC分类号： A61K36/81 ,  A23L1/00

摘要： The present invention relates to the use of a fruit extract and optionally other specific nutrients for preventing, reducing or minimising exercise-induced systemic inflammation and/or for promoting recovery from intense exercise. The invention also relates to compositions comprising such fruit extracts.

摘要翻译： 本发明涉及水果提取物和任选的其他特定营养素用于预防，减少或最小化运动诱发的全身性炎症和/或促进强烈运动恢复的用途。 本发明还涉及包含这种水果提取物的组合物。

公开(公告)号：EP2934560B1

公开(公告)日：2020-09-23

申请号：EP13815828.2

申请日：2013-12-24

申请人： Provexis Natural Products Limited

发明人： O'KENNEDY, Niamh

IPC分类号： A61K36/81 ,  A61K31/525 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A61K31/519

公开(公告)号：EP2355811A2

公开(公告)日：2011-08-17

申请号：EP09759760.3

申请日：2009-11-02

申请人： Provexis Natural Products Limited

发明人： O'KENNEDY, Niamh

IPC分类号： A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61K31/7034 ,  A61K45/06 ,  A61P7/02 ,  A61P9/00

CPC分类号： A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61K31/353 ,  A61K31/7034 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/48092 ,  A61K47/549

摘要： The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C
1 or C
2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH; for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow

公开(公告)号：EP2349303B1

公开(公告)日：2017-01-11

申请号：EP09756337.3

申请日：2009-11-02

申请人： Provexis Natural Products Limited

发明人： O'KENNEDY, Niamh

IPC分类号： A61K36/81

CPC分类号： A61K36/81 ,  A61K31/7048 ,  A61K31/7064

公开(公告)号：EP2349303A2

公开(公告)日：2011-08-03

申请号：EP09756337.3

申请日：2009-11-02

申请人： Provexis Natural Products Limited

发明人： O'KENNEDY, Niamh

IPC分类号： A61K36/81 ,  A61K31/00

CPC分类号： A61K36/81 ,  A61K31/7048 ,  A61K31/7064

摘要： Provided are methods of making an extract of fruit of the
Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.

公开(公告)号：EP1848451A2

公开(公告)日：2007-10-31

申请号：EP06709758.4

申请日：2006-02-14

申请人： Provexis Natural Products Limited

发明人： CROSBIE, Lynn ,  O'KENNEDY, Niamh

IPC分类号： A61K36/81

CPC分类号： A61K36/81

摘要： The invention provides the use of a water soluble tomato extract or an active fraction thereof for the manufacture of a medicament for lowering plasma triglyceride levels, the water soluble tomato extract or active fraction thereof being substantially free of lycopene and being substantially free from water-insoluble particulate material. Also provided by the invention is a method of lowering triglyceride levels in the blood of a patient through the administration of the water soluble tomato extracts.