公开(公告)号：EP3453402A1

公开(公告)日：2019-03-13

申请号：EP18183272.6

申请日：2013-01-12

申请人： Bioverativ Therapeutics Inc. ,  Puget Sound Blood Center

发明人： JIANG, Haiyan ,  LIU, Tongyao ,  KRISHNAMOORTHY, Sriram ,  JOSEPHSON, Neil ,  GLENN, Pierce

IPC分类号： A61K38/21 ,  A61K38/37 ,  A61K39/00 ,  A61K47/68 ,  C12Q1/68 ,  C07K14/755 ,  C12Q1/6883

摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.

公开(公告)号：EP2802668A1

公开(公告)日：2014-11-19

申请号：EP13735995.6

申请日：2013-01-12

申请人： Biogen Idec MA Inc. ,  Puget Sound Blood Center

发明人： JIANG, Haiyan ,  LIU, Tongyao ,  KRISHNAMOORTHY, Sriram ,  JOSEPHSON, Neil ,  GLENN, Pierce

IPC分类号： C12P21/04

CPC分类号： A61K47/48415 ,  A61K38/21 ,  A61K38/37 ,  A61K39/0008 ,  A61K47/6811 ,  A61K47/6815 ,  A61K2039/6031 ,  A61K2039/6056 ,  C07K14/755 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  A61K2300/00

摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.

公开(公告)号：EP3970737A1

公开(公告)日：2022-03-23

申请号：EP21184612.6

申请日：2013-01-12

申请人： Bioverativ Therapeutics Inc. ,  Puget Sound Blood Center

发明人： JIANG, Haiyan ,  LIU, Tongyao ,  KRISHNAMOORTHY, Sriram ,  JOSEPHSON, Neil ,  GLENN, Pierce

IPC分类号： A61K38/21 ,  A61K38/37 ,  A61K39/00 ,  A61K47/68 ,  C12Q1/68 ,  C07K14/755 ,  C12Q1/6883 ,  A61P1/00 ,  A61P1/02 ,  A61P7/00 ,  A61P7/04 ,  A61P11/00 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P37/06

摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e . g ., a full or partial deletion of the B domain.

公开(公告)号：EP0229830B1

公开(公告)日：1994-11-09

申请号：EP86904617.7

申请日：1986-07-02

申请人： Puget Sound Blood Center and Program ,  Fred Hutchinson Cancer Research Center

发明人： SLICHTER, Sherill J. ,  DEEG, H. Joachim

IPC分类号： A61K41/00 ,  A61M1/36

CPC分类号： A61K41/0023 ,  A61K41/0019

摘要： The immunogenicity of transfused or transplanted allogenic tissue is reduced by either directly exposing the tissue to ultraviolet (UV) irradiation prior to administering the tissue to the recipient or by inducing a state of tolerance in the recipient to non-UV or UV-irradiated allogeneic tissue by prior exposure to UV-irradiated allogenic tissue.

公开(公告)号：EP2742949A1

公开(公告)日：2014-06-18

申请号：EP13191686.8

申请日：2010-11-15

申请人： Puget Sound Blood Center ,  James, Eddie Arthur

发明人： Pratt, Kathleen ,  Ettinger, Ruth

IPC分类号： A61K38/37

CPC分类号： C07K14/755 ,  A61K38/00

摘要： Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.

摘要翻译： 本文提供了用于在患有血友病A的患者中预防或降低对因子VIII的初始免疫应答的方法和组合物，并且用于降低具有针对因子VIII的预先形成的抑制剂抗体的患者中免疫应答的强度。

公开(公告)号：EP2734841A2

公开(公告)日：2014-05-28

申请号：EP12814998.6

申请日：2012-07-20

申请人： University of Washington Through Its Center for Comercialization ,  Puget Sound Blood Center ,  Jiang, Shaoyl

发明人： BRAULT, Norman, D. ,  JIANG, Shaoyi ,  RATNER, Daniel, M. ,  JOHNSEN, Jill, M. ,  KIRK, James, T. ,  LOPEZ, Jose, A.

IPC分类号： G01N33/52 ,  G01N33/53 ,  G01N33/80

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

摘要翻译： 提供了用于检测生物溶液（例如全血）中的分析物的光子器件，系统和方法。 代表性的光子器件是具有纳米尺度特征和微米尺寸直径的光环谐振器。 由于这些器件的紧凑尺寸，许多谐振器可以被布置在单个衬底上，并且当样品通过器件时同时测试。 典型的分析物包括血细胞，抗体和病原体，以及指示血细胞或病原体存在的化合物（例如血清学）。 在某些实施方案中，血液类型可以通过使用血细胞直接检测和血清学的组合的光子感测来确定。 通过组合多个装置的检测信号，可以确定血液的类型。

公开(公告)号：EP2498803A2

公开(公告)日：2012-09-19

申请号：EP10830866.9

申请日：2010-11-15

申请人： Puget Sound Blood Center

发明人： PRATT, Kathleen ,  ETTINGER, Ruth ,  JAMES, Eddie. Arthur.

IPC分类号： A61K38/37

CPC分类号： C07K14/755 ,  A61K38/00

摘要： Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.

公开(公告)号：EP2802668B1

公开(公告)日：2018-08-01

申请号：EP13735995.6

申请日：2013-01-12

申请人： Bioverativ Therapeutics Inc. ,  Puget Sound Blood Center

发明人： JIANG, Haiyan ,  LIU, Tongyao ,  KRISHNAMOORTHY, Sriram ,  JOSEPHSON, Neil ,  GLENN, Pierce

IPC分类号： A61K38/21 ,  A61K38/37 ,  A61K39/00 ,  C12Q1/68 ,  C07K14/755 ,  A61K47/50 ,  C12Q1/6883 ,  A61K47/68

CPC分类号： C12Q1/6883 ,  A61K38/21 ,  A61K38/37 ,  A61K39/0008 ,  A61K47/6811 ,  A61K47/6815 ,  A61K2039/6031 ,  A61K2039/6056 ,  C07K14/755 ,  C07K2319/30 ,  C12Q2600/156 ,  A61K2300/00

摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.

公开(公告)号：EP2734841B1

公开(公告)日：2017-07-05

申请号：EP12814998.6

申请日：2012-07-20

申请人： University of Washington through its Center for Commercialization ,  Puget Sound Blood Center

发明人： BRAULT, Norman D. ,  JIANG, Shaoyi ,  RATNER, Daniel M. ,  JOHNSEN, Jill M. ,  KIRK, James T. ,  LOPEZ, Jose A.

IPC分类号： G01N33/543 ,  G01N33/80

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

公开(公告)号：EP2890982A2

公开(公告)日：2015-07-08

申请号：EP13832087.4

申请日：2013-08-28

申请人： Puget Sound Blood Center

发明人： ZIMRING, James, Charles

IPC分类号： G01N33/53

CPC分类号： G01N33/80 ,  G01N33/5005 ,  G01N33/53 ,  G01N2800/7066

摘要： Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.