公开(公告)号：EP2734841B1

公开(公告)日：2017-07-05

申请号：EP12814998.6

申请日：2012-07-20

申请人： University of Washington through its Center for Commercialization ,  Puget Sound Blood Center

发明人： BRAULT, Norman D. ,  JIANG, Shaoyi ,  RATNER, Daniel M. ,  JOHNSEN, Jill M. ,  KIRK, James T. ,  LOPEZ, Jose A.

IPC分类号： G01N33/543 ,  G01N33/80

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

公开(公告)号：EP3068378A1

公开(公告)日：2016-09-21

申请号：EP14862645.0

申请日：2014-11-12

申请人： University of Washington through its Center for Commercialization

发明人： STAYTON, Patrick S. ,  CONVERTINE, Anthony ,  RATNER, Daniel M. ,  SRINIVASAN, Selvi ,  DAS, Debobrato ,  SU, Fang-Yi ,  CHEN, Jasmin ,  CHIU, David Yee-Shawn ,  LANE, Daniel Douglas

IPC分类号： A61K9/14 ,  A61P31/00

CPC分类号： A61K47/48176 ,  A61K9/1075 ,  A61K9/1271 ,  A61K31/337 ,  A61K31/407 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/7036 ,  A61K47/58 ,  A61K47/60 ,  A61K47/644 ,  A61K47/6907 ,  A61K47/6915

摘要： Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.