公开(公告)号：EP3151913A4

公开(公告)日：2017-11-15

申请号：EP15802894

申请日：2015-06-03

申请人： RIDDER DIRK DE

发明人： RIDDER DIRK DE

IPC分类号： A61N1/36

CPC分类号： A61N1/36025 ,  A61N1/36082

摘要： In embodiments of the present disclosure, methods of treating a neurological disorder comprise providing reconditioning electrical stimulation. The methods may comprise applying electrical stimulation that provides positive reinforcement by activation within the reward network of the brain of the patient when an appropriate external stimulus is provided to the patient. The external stimulus is selected in accordance with the specific neurological disorder being treated in the patient. The methods may comprise applying electrical stimulation that provides negative reinforcement by stimulation of aversion-related locations of the brain of the patient when a different external stimulus is provided to the patient.

公开(公告)号：EP3316959A1

公开(公告)日：2018-05-09

申请号：EP16817313.6

申请日：2016-06-30

申请人： Ridder, Dirk, De

发明人： Ridder, Dirk, De

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36135 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/128 ,  A61B5/4836 ,  A61B5/6868 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36167

摘要： Representative embodiments are directed to detecting neurological activity in a patient. The detection of neurological activity includes identifying cross-frequency coupling and determining whether the cross-frequency coupling is physiological or pathological. When pathological cross-frequency coupling is detected, neurostimulation of one or more sites is applied. In some embodiments, an implantable pulse generator is adapted to analyze neural activity for pathological cross-frequency coupling and to provide electrical stimulation in response to the detected pathological cross-frequency coupling.

公开(公告)号：EP3191178A2

公开(公告)日：2017-07-19

申请号：EP15839727.3

申请日：2015-09-11

申请人： Ridder, Dirk, De

发明人： Ridder, Dirk, De

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36178 ,  A61N1/36192 ,  A61N1/36196

摘要： A method and system are provided to deliver nested stimulation to brain tissue of interest. The method and system set first parameters that define a carrier waveform. The method and system set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the brain tissue of interest. The method and system operates a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform. The nested stimulation waveform has a plurality of pulse bursts. The method and system deliver the nested stimulation waveform through one or more electrodes to the brain tissue of interest.

摘要翻译： 提供了一种方法和系统来向感兴趣的脑组织递送嵌套刺激。 该方法和系统设定定义载波波形的第一参数。 该方法和系统设定限定高频波形的第二参数，其中载波波形和高频波形中的至少一个被定义为对应于与感兴趣的脑组织相关联的生理神经振荡。 该方法和系统操作脉冲发生器以生成组合载波波形和高频波形的嵌套刺激波形。 嵌套刺激波形具有多个脉冲串。 该方法和系统通过一个或多个电极将嵌套的刺激波形传递到感兴趣的脑组织。

公开(公告)号：EP3191178A4

公开(公告)日：2018-07-04

申请号：EP15839727

申请日：2015-09-11

申请人： RIDDER DIRK DE

发明人： RIDDER DIRK DE

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36178 ,  A61N1/36192 ,  A61N1/36196

摘要： A method and system are provided to deliver nested stimulation to brain tissue of interest. The method and system set first parameters that define a carrier waveform. The method and system set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the brain tissue of interest. The method and system operates a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform. The nested stimulation waveform has a plurality of pulse bursts. The method and system deliver the nested stimulation waveform through one or more electrodes to the brain tissue of interest.

公开(公告)号：EP3151913A1

公开(公告)日：2017-04-12

申请号：EP15802894.4

申请日：2015-06-03

申请人： Ridder, Dirk, De

发明人： Ridder, Dirk, De

IPC分类号： A61N1/36

CPC分类号： A61N1/36025 ,  A61N1/36082

摘要： In embodiments of the present disclosure, methods of treating a neurological disorder comprise providing reconditioning electrical stimulation. The methods may comprise applying electrical stimulation that provides positive reinforcement by activation within the reward network of the brain of the patient when an appropriate external stimulus is provided to the patient. The external stimulus is selected in accordance with the specific neurological disorder being treated in the patient. The methods may comprise applying electrical stimulation that provides negative reinforcement by stimulation of aversion-related locations of the brain of the patient when a different external stimulus is provided to the patient.

摘要翻译： 在本公开的实施方案中，治疗神经疾病的方法包括提供整修电刺激。 该方法可包括将电刺激做由患者的大脑的奖励网络内的激活提供积极的强化。当适当的外部刺激提供给患者。 外部刺激是在舞蹈雅选择为与特定的神经疾病中，患者正在接受治疗。 该方法可包括将电刺激通过做的患者的脑的厌恶相关位置刺激提供负筋当不同的外部刺激提供给患者。