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    SYSTEM AND METHOD FOR NESTED NEUROSTIMULATION
    1.
    发明公开
    SYSTEM AND METHOD FOR NESTED NEUROSTIMULATION 审中-公开

    公开(公告)号：EP3191178A4

    公开(公告)日：2018-07-04

    申请号：EP15839727

    申请日：2015-09-11

    申请人： RIDDER DIRK DE

    发明人： RIDDER DIRK DE

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36171 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36178 ,  A61N1/36192 ,  A61N1/36196

    摘要： A method and system are provided to deliver nested stimulation to brain tissue of interest. The method and system set first parameters that define a carrier waveform. The method and system set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the brain tissue of interest. The method and system operates a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform. The nested stimulation waveform has a plurality of pulse bursts. The method and system deliver the nested stimulation waveform through one or more electrodes to the brain tissue of interest.

    NEUROSTIMULATION SYSTEM FOR ESTIMATING DESIRED STIMULATION AMPLITUDE FOR ELECTRODE CONFIGURATION
    4.
    发明公开
    NEUROSTIMULATION SYSTEM FOR ESTIMATING DESIRED STIMULATION AMPLITUDE FOR ELECTRODE CONFIGURATION 有权
    神经病学系统ZUR KURKULATION DERGEWÜNSCHTENSTIMULATIONSAMPLITUDEFÜRELEKTRODENKONFIGURATION

    公开(公告)号：EP2654879A1

    公开(公告)日：2013-10-30

    申请号：EP11808116.5

    申请日：2011-12-22

    申请人： Boston Scientific Neuromodulation Corporation

    发明人： ZHU, Changfang ,  LEE, Dongchul

    IPC分类号： A61N1/36 ,  A61N1/372 ,  A61B5/04

    CPC分类号： A61N1/36192 ,  A61B5/04001 ,  A61B5/407 ,  A61N1/36071 ,  A61N1/36128 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36185 ,  A61N1/37247 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/20

    摘要： A neurostimulation system comprises a user input device configured for receiving input from a user, and processing circuitry configured for (a) selecting a first electrode configuration in response to receiving the user input, (b) predicting a neural response induced by electrical energy theoretically conveyed by the first electrode configuration at a specified amplitude, (c) deriving a metric value from the predicted neural response, (d) comparing the metric value to a reference threshold value, (e) adjusting the specified amplitude of the electrical energy if the metric value is not in a specified range relative to the reference threshold value, (f) repeating steps (b)-(e) using the adjusted amplitude as the specified amplitude until the metric value is in the specific range relative to the reference threshold value, and (g) instructing a neurostimulation device to deliver the electrical energy at the adjusted amplitude via the first electrode configuration to stimulate the patient.

    摘要翻译： 一种神经刺激系统包括被配置用于从用户接收输入的用户输入装置和配置用于（a）响应于接收到用户输入选择第一电极配置的处理电路，（b）预测理论上传达的电能诱发的神经反应 通过所述第一电极配置以指定的幅度，（c）从所述预测的神经反应导出度量值，（d）将所述度量值与参考阈值进行比较，（e）如果所述度量值的度量 值不在相对于参考阈值的指定范围内;（f）使用所调整的幅度作为指定幅度重复步骤（b） - （e），直到度量值相对于参考阈值在特定范围内， 以及（g）指示神经刺激装置经由所述第一电极配置传递经调节的振幅的电能以刺激患者。

    METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN
    6.
    发明公开
    METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN 审中-公开
    用于疼痛的多模式电调制的方法和设备

    公开(公告)号：EP3291878A1

    公开(公告)日：2018-03-14

    申请号：EP16769480.1

    申请日：2016-03-21

    申请人： Vallejo, Ricardo ,  Cedeno, David Leonardo ,  Benyamin, Rasmin M.

    发明人： Vallejo, Ricardo ,  Cedeno, David Leonardo ,  Benyamin, Rasmin M.

    IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/378

    CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/36189 ,  A61N1/36192 ,  A61N1/36196 ,  A61N2/002 ,  A61N2/008

    摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.

    SYSTEM AND METHOD FOR NESTED NEUROSTIMULATION
    7.
    发明公开
    SYSTEM AND METHOD FOR NESTED NEUROSTIMULATION 审中-公开
    用于嵌套神经刺激的系统和方法

    公开(公告)号：EP3191178A2

    公开(公告)日：2017-07-19

    申请号：EP15839727.3

    申请日：2015-09-11

    申请人： Ridder, Dirk, De

    发明人： Ridder, Dirk, De

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36171 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36178 ,  A61N1/36192 ,  A61N1/36196

    摘要： A method and system are provided to deliver nested stimulation to brain tissue of interest. The method and system set first parameters that define a carrier waveform. The method and system set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the brain tissue of interest. The method and system operates a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform. The nested stimulation waveform has a plurality of pulse bursts. The method and system deliver the nested stimulation waveform through one or more electrodes to the brain tissue of interest.

    摘要翻译： 提供了一种方法和系统来向感兴趣的脑组织递送嵌套刺激。 该方法和系统设定定义载波波形的第一参数。 该方法和系统设定限定高频波形的第二参数，其中载波波形和高频波形中的至少一个被定义为对应于与感兴趣的脑组织相关联的生理神经振荡。 该方法和系统操作脉冲发生器以生成组合载波波形和高频波形的嵌套刺激波形。 嵌套刺激波形具有多个脉冲串。 该方法和系统通过一个或多个电极将嵌套的刺激波形传递到感兴趣的脑组织。

    CRANIAL ELECTROSTIMULATION DEVICE FOR TREATMENT OF POLYSUBSTANCE ADDICTION AND METHOD OF USE
    9.
    发明公开
    CRANIAL ELECTROSTIMULATION DEVICE FOR TREATMENT OF POLYSUBSTANCE ADDICTION AND METHOD OF USE 审中-公开
    SKULL电刺激设备，用于多个药物依赖性和使用方法的治疗

    公开(公告)号：EP2349465A2

    公开(公告)日：2011-08-03

    申请号：EP09822574.1

    申请日：2009-10-20

    申请人： Seaboard Assets Corp.

    发明人： MOYER, Eric P. ,  WINSTON, Joseph R.

    IPC分类号： A61N1/36 ,  A61N1/18

    CPC分类号： A61N1/36089 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36192

    摘要： The cranial electrostimulation devices described herein are suitable for use in detoxification from and amelioration of the symptoms of acute and chronic withdrawal from simultaneous multiple addictive substances by transcutaneous electric nerve stimulation. A plurality of time-division multiplexed analog waveforms is applied to the mastoid process of a person in need thereof, thereby treating symptoms of withdrawal from addictive substances. The invention also provides a protocol for encoding a plurality of different waveforms combined sequentially or simultaneously, as well as an improved cranial electrostimulation apparatus having a stable output waveform signal over the useful service life of the power supply, e.g., the battery.