摘要:
This invention relates to a method and apparatus for forming soft capsules and provides novel processing flexibility. The apparatus includes extrusion die (130) as an alternative to spreader boxes, the use of melt-on-demand technology to enhance the long term stability of the film-forming materials and a casting drum (9). Preferred embodiments provide a positive displacement pump to transport the molten film-forming material from the melt-on-demand device to the extrusion device (130) and preferably a reservoir means disposed between said extrusion device (130) and the means to melt said film-forming material. The encapsulation apparatus may also include a valved injection wedge.
摘要:
The present invention relates to a method and an apparatus for forming soft capsules and provides novel processing flexibility. The apparatus comprises a three-way valve injector wedge (110). The three-way valve injector wedge allows for set-up of the encapsulation machine with a placebo fill and quick change over to active fill. This conserves use of the active ingredient.
摘要:
A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.
摘要:
Disclosed herein are compositions comprising a modified starch and a carrageenan, especially iota-carrageenan, where the compositions are suitable for use in manufacturing soft capsules.
摘要:
Improved formulations containing substituted imidazole derivatives of the general formula 1, formula (I) wherein Y is -CH 2 - or -CO-, R 1 is H, halo or hydroxy, R 2 is H or halo, and R 3 is H or lower alkyl (e.g. C 1 to C 4 alkyl, preferably C 1 or C 2 alkyl), or a pharmaceutically acceptable salt, such as an acid addition salt, e.g. the hydrochloride, of a compound of the general formula (I), are in solid fast-dispersing dosage form suitable for pre-gastric absorption.