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    Curcumin derivatives with improved physicochemical properties and nanoliposomes surface-decorated with the derivatives with very high affinity for amyloid-beta1-42 peptide
    2.
    发明公开
    Curcumin derivatives with improved physicochemical properties and nanoliposomes surface-decorated with the derivatives with very high affinity for amyloid-beta1-42 peptide 审中-公开
    具有改进的物理化学性质，并与衍生物姜黄素衍生物表面装饰的纳米脂质体具有非常高的淀粉样肽亲和力beta1-42

    公开(公告)号：EP2436673A1

    公开(公告)日：2012-04-04

    申请号：EP11007990.2

    申请日：2011-09-30

    申请人： Niaraki, Anna ,  University Of Patras ,  Università degli Studi di Milano - Bicocca ,  Antimisiari Sofia ,  Mourtas, Spiridon

    发明人： Antimisiari, Sophia ,  Mourtas, Spiridon ,  Niaraki, Anna ,  Zona, Cristiano ,  Masserini, Massimo ,  Nicotra, Francesco ,  La Ferla, Barbara

    IPC分类号： C07D231/12 ,  C07D403/12 ,  A61K9/127 ,  A61K31/415 ,  A61K31/4192 ,  A61P25/00

    CPC分类号： C07D231/12 ,  A61K9/127 ,  A61K47/55 ,  A61K47/6911 ,  C07D403/12

    摘要： Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD). It has been previously shown that curcumin targets Aβ plaques and interferes with their formation, suggesting a potential role for prevention or treatment of AD. In the present invention, curcumin-derivatives with improved physicochemical properties were synthesized and a "click chemistry" as well as a conventional liposome preparation method, were used to generate nanoliposomes decorated with the curcumin derivatives. These derivatives were designed to maintain the planar structure required for interaction with Aβ, as directly confirmed by Surface Plasmon Resonance experiments. Surface Plasmon Resonance experiments, measuring the binding of flowing liposomes to immobilized Aβ1-42, indicated that the liposomes exposing curcumin derivatives have extremely high affinity for Aβ1-42 fibrils (1-5 nM), likely because of the occurrence of multivalent interactions. The present invention describes the synthesis of the curcumin derivatives and the preparation and characterization of new nanoliposomes with a very high affinity for Aβ1-42 fibrils, to be exploited as vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD.

    摘要翻译： 淀粉样蛋白²（安培）聚集体被认为是阿耳茨海默氏病（AD）的治疗和/或诊断可能的目标。 它先前已表明没有姜黄素目标A²斑块和干扰了它们的形成，这对预防或治疗AD的潜在作用。 在本发明中，姜黄素衍生物具有改善的物理化学性质的合成和一个“点击化学”，以及作为以往的脂质体的制备方法，被用来产生纳米脂质体装饰的姜黄素衍生物。 这些衍生物被设计为保持用于与A²相互作用所需要的平面结构，如直接通过表面等离子体共振实验所证实。 表面等离子体共振实验，测量流至固定化脂质体A²1-42的结合，并指示的脂质体暴露姜黄素衍生物具有用于A²1-42原纤维（1-5纳米），很可能是因为多价相互作用的发生的非常高的亲和力。 本发明描述了姜黄素衍生物的合成和制备和新的纳米脂质体表征具有非常高的亲和力A²1-42原纤，被利用作为用于新的诊断和治疗性分子为AD靶向递送载体。

    STRONGLY FAIL-SAFE INTERFACE BASED ON CONCURRENT CHECKING
    4.
    发明公开
    STRONGLY FAIL-SAFE INTERFACE BASED ON CONCURRENT CHECKING 失效
    ON同步测试为主的FAIL-SAFE INTERFACE

    公开(公告)号：EP0695442A1

    公开(公告)日：1996-02-07

    申请号：EP94924968.0

    申请日：1994-09-02

    申请人： SOFIA KOLONI LTD.

    发明人： NICOLAIDIS, Michael

    IPC分类号： G06F11 ,  H03K19

    CPC分类号： G06F11/0796 ,  G06F11/085 ,  H03K19/0075

    摘要： PCT No. PCT/GR94/00021 Sec. 371 Date May 1, 1995 Sec. 102(e) Date May 1, 1995 PCT Filed Sep. 2, 1994 PCT Pub. No. WO95/06908 PCT Pub. Date Mar. 9, 1995The present invention relates to a fail-safe control interface including branches for providing signals having a safe state or a non-safe state. Each branch comprises inputs for receiving at least two binary control signals (Si, Si*); a source of a non-safe state (Fe) connectable through a basic chain of elements (14, 15) to an output (Oi) when the control signals realize a predetermined combination; a concurrent checker (17) providing an error detection signal (g1, g2) if the inputs of a pair of its inputs are at predetermined states; and means (14*) for providing a first input of said pair of inputs with a signal corresponding to the state of said output and the second input of said pair of inputs with a signal corresponding to the output of a duplicate chain of the basic chain, this duplicate chain reacting like the basic chain in response to the control signals.

    TRANSPARENT TESTING OF INTEGRATED CIRCUITS
    5.
    发明公开
    TRANSPARENT TESTING OF INTEGRATED CIRCUITS 失效
    透明测试集成电路。

    公开(公告)号：EP0585435A1

    公开(公告)日：1994-03-09

    申请号：EP93905586.0

    申请日：1993-03-05

    申请人： SOFIA KOLONI LTD.

    发明人： NICOLAIDIS, Michael

    IPC分类号： G01R31 ,  G06F11 ,  G11C29

    CPC分类号： G01R31/318527 ,  G01R31/318533 ,  G01R31/318536 ,  G06F11/221 ,  G06F11/2273 ,  G06F11/27 ,  G06F11/2733 ,  G06F2201/83 ,  G11C29/32 ,  G11C29/40

    摘要： Technique de contrôle transparent de circuits intégrés. Elle permet de contrôler les circuits intégrés sans perdre le contexte d'exécution des applications, et s'applique à deux types de blocs, à savoir d'une part les blocs combinatoires et séquentiels, et d'autre part les mémoires vives et les fichiers de registres. Pour le premier type de bloc, on a mis au point une technique de stockage, de contrôle et de restitution. Elle met en oeuvre une trajectoire circulaire de balayage et consiste à transférer, par l'intermédiaire de la trajectoire de balayage, le contenu de divers registres aux entrées de données d'une mémoire vive, à stocker le contenu des registres dans la mémoire vive, à effectuer le contrôle, à transférer les données stockées à la trajectoire de balayage, et à les transférer aux registres correspondants. Pour le second type de bloc, on a mis au point une technique de contrôle transparent permettant de contrôler les mémoires vives sans en détruire le contenu initial. A cette fin, on a mis au point une technique permettant de dériver des processus de contrôle transparent de mémoire vive. La mise en oeuvre de ces processus de contrôle peut s'effectuer selon des techniques d'autocontrôle ou des techniques à trajectoire de balayage. Les processus de contrôle transparent se composent d'un processus de prédiction ou d'initialisation de signatures ou d'un processus de contrôle transparent de base. Le processus de contrôle par prédiction de signature est obtenu par l'élimination de toutes les opérations d'écriture du processus de contrôle transparent de base. On peut également éliminer les opérations de lecture de sorte que les données de lecture ne soient pas introduites dans la méthode de compression de sortie. Cette technique évite tout masquage d'erreurs dû aux erreurs produites à la fois lors du processus de contrôle par prédiction de signature, et lors du processus de contrôle transparent de base. Ce dernier est obtenu selon plusieurs étapes de transformation à partir d'un processus de contrôle normal

    DRUG DISPENSING DEVICE
    7.
    发明公开
    DRUG DISPENSING DEVICE 审中-公开

    公开(公告)号：EP3449892A1

    公开(公告)日：2019-03-06

    申请号：EP17731270.9

    申请日：2017-04-27

    申请人： Machado Pires, Catarina Sofia

    发明人： Machado Pires, Catarina Sofia

    IPC分类号： A61J1/06 ,  A44C5/00

    摘要： The present application describes a drug dispensing device.
    The device is comprised of an armband, a rigid housing, made of polymeric or composite material, with any geometric shape, which separates in two along the longitudinal axis, incorporating therein a capsule containing a concentrated fluid whose geometric shape allows its storage within said housing. The centre of the top of one of the capsule faces contains a valve which, upon being actuated by at least one flexible tab, by pressing the mouth of the user, is expelled from the inside of the capsule, allowing him to suck the concentrated fluid contained therein.
    In this way, the device allows the user to correct the reference values quickly and effectively and thus regain the sense of physical safety while practicing sports in extreme situations or while practicing activities in water environments.

    PAN FOR BAKING BREAD
    9.
    发明公开
    PAN FOR BAKING BREAD 有权
    BACKFORMFÜRBROT

    公开(公告)号：EP2916658A1

    公开(公告)日：2015-09-16

    申请号：EP13821165.1

    申请日：2013-10-29

    申请人： Magar Invest S.L. ,  Ferreira Santos, Raquel Sofia

    发明人： MARIN MORO, Tomás

    IPC分类号： A21B3/13

    CPC分类号： A21B3/135 ,  A21B3/134

    摘要： It comprises a plurality of baking moulds (2), a plate (3) acting as a cover of said pan (1), and means to prevent the raising of said plate as the bread is baked inside said moulds, and is characterized in that said means to prevent the raising of said plate comprise a fastening device (12) associated to a structure (9, 22) of said pan (1), said fastening device (12) including at least one hook (11) which is hingedly joined to a shaft (23) of said structure (9, 22), said hook (11) being susceptible of catching a portion (3a, 3b) of said plate (3) when it tilts on said shaft (23).

    摘要翻译： 它包括多个烘烤模具（2），用作所述锅（1）的盖子的板（3），以及当在所述模具内烤面包时防止所述板升起的装置，其特征在于： 所述防止所述板升高的装置包括与所述盘（1）的结构（9,22）相关联的紧固装置（12），所述紧固装置（12）包括至少一个钩（11），所述钩（11）铰接 到所述结构（9,22）的轴（23）时，所述钩（11）在所述轴（23）上倾斜时易于卡住所述板（3）的一部分（3a，3b）。