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1.发明公开Lipid Film Structure Containing a Polyoxyalkylene Chain-Containing Lipid Derivative. 有权脂质膜结构，其包括脂质衍生物Polyoxyalkylenkettenhaltiges
公开(公告)号：EP2382996A3
公开(公告)日：2012-03-28
申请号：EP11172230.2
申请日：2006-02-17
发明人： KIWADA, Hiroshi , ISHIDA, Tatsuhiro , ITO, Chika , KUBO, Kazuhiro , SAKANOUE, Kenji , KIKUCHI, Hiroshi
CPC分类号： C07K7/06 , A61K9/1271 , A61K47/60 , A61K47/62 , C07K5/0806 , C07K5/1008
摘要： A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1):
wherein L, Y, W, X 1 , X 2 , X 3 , OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.-
2.发明公开Lipid Film Structure Containing a Polyoxyalkylene Chain-Containing Lipid Derivative. 有权Lipidfilmstruktur enthaltend ein Polyoxenylenkettenhaltiges Lipidderivat
公开(公告)号：EP2382996A2
公开(公告)日：2011-11-02
申请号：EP11172230.2
申请日：2006-02-17
发明人： KIWADA, Hiroshi , ISHIDA, Tatsuhiro , ITO, Chika , KUBO, Kazuhiro , SAKANOUE, Kenji , KIKUCHI, Hiroshi
CPC分类号： C07K7/06 , A61K9/1271 , A61K47/60 , A61K47/62 , C07K5/0806 , C07K5/1008
摘要： A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1):
wherein L, Y, W, X 1 , X 2 , X 3 , OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.摘要翻译： 由下式（1）表示的含有聚氧化烯链的脂质衍生物：其中L，Y，W，X 1，X 2，X 3，OA，Z，m1，m2，m3，n1，n2和n3 如本说明书中所定义。
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3.发明授权Lipid film structure containing a polyoxyalkylene chain-containing lipid derivative. 有权脂质膜结构，其包括脂质衍生物Polyoxyalkylenkettenhaltiges
公开(公告)号：EP2382996B1
公开(公告)日：2015-01-14
申请号：EP11172230.2
申请日：2006-02-17
发明人： KIWADA, Hiroshi , ISHIDA, Tatsuhiro , ITO, Chika , KUBO, Kazuhiro , SAKANOUE, Kenji , KIKUCHI, Hiroshi
CPC分类号： C07K7/06 , A61K9/1271 , A61K47/60 , A61K47/62 , C07K5/0806 , C07K5/1008
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4.发明公开PEPTIDE IMPARTING ANTIBODY-BINDING ABILITY TO LIPOSOME AND LIPOSOME MODIFIED WITH THE SAME 审中-公开PEPTID，DAS LIPOSOMENANTIKÖRPERBINDUNGSVERMÖGENVERLEIHT，UND DAMIT MODIFIZIERTES LIPOSOM
公开(公告)号：EP2213735A1
公开(公告)日：2010-08-04
申请号：EP08846313.8
申请日：2008-10-20
IPC分类号： C12N15/09 , A61K9/127 , A61K39/395 , A61K47/42 , C07K14/005 , C07K14/31 , C07K19/00
CPC分类号： A61K39/44 , A61K9/1271 , A61K47/62 , A61K47/6911 , A61K47/6913 , C07K14/005 , C07K14/31 , C07K2317/00 , C07K2319/03 , C07K2319/10 , C07K2319/21 , C07K2319/705 , C12N2795/00022
摘要： The present invention provides a liposome having antibody-binding ability and a preparation method thereof, and an antibody-modified liposome and a preparation method thereof. The antibody-binding liposome of the invention is characterized by having a surface modified with a peptide having an amino acid sequence represented by SEQ ID NO: 1, or a peptide functionally equivalent thereto. Moreover, the antibody-modified liposome of the invention is characterized by being obtained by binding an antibody to the above antibody-binding liposome via the peptide having the amino acid sequence of SEQ ID NO: 1, or a peptide functionally equivalent thereto.
摘要翻译： 本发明提供具有抗体结合能力的脂质体及其制备方法和抗体修饰的脂质体及其制备方法。 本发明的抗体结合脂质体的特征在于具有由具有SEQ ID NO：1所示的氨基酸序列的肽修饰的表面或与其功能等同的肽。 此外，本发明的抗体修饰的脂质体的特征在于通过经由具有SEQ ID NO：1的氨基酸序列的肽或与其功能等同的肽将抗体与上述抗体结合脂质体结合而得到。
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5.发明公开STABLE OXALIPLATIN-ENCAPSULATING LIPOSOME AQUEOUS DISPERSION AND METHOD FOR STABILIZING SAME 审中-公开STABILE OXALIPLATIN-VERKAPSELNDEWÄSSRIGELIPOSOMDISPERSION UND STABILISIERUNGSVERFAHRENDAFÜR
公开(公告)号：EP2883542A1
公开(公告)日：2015-06-17
申请号：EP13827386.7
申请日：2013-08-09
发明人： DOI, Yusuke , ISHIDA, Tatsuhiro
IPC分类号： A61K31/282 , A61K9/127 , A61K47/22 , A61K47/24
CPC分类号： A61K9/127 , A61K31/282 , A61K31/555 , A61K45/06 , A61K47/22 , A61K2300/00
摘要： An object of the present invention is to provide an oxaliplatin-encapsulating liposome aqueous dispersion that has excellent long-term storage stability. The present invention provides an aqueous dispersion of liposomes encapsulating oxaliplatin, the oxaliplatin-encapsulating liposome aqueous dispersion containing 2-morpholinoethanesulfonic acid in an external aqueous phase.
摘要翻译： 本发明的目的是提供具有优异的长期储存稳定性的含奥沙利铂包封的脂质体水分散体。 本发明提供了包封奥沙利铂的脂质体的含水分散体，含有2-吗啉代乙磺酸的奥沙利铂包封的脂质体水分散体在外部水相中。
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6.发明授权
公开(公告)号：EP2246056B1
公开(公告)日：2014-08-27
申请号：EP09706367.1
申请日：2009-01-29
发明人： ISHIDA, Tatsuhiro , KIWADA, Hiroshi
IPC分类号： A61K31/513 , A61K9/127 , A61K31/282 , A61K31/4412 , A61K31/53 , A61K47/24 , A61K47/34 , A61P35/00 , A61P43/00
CPC分类号： A61K31/282 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/555 , A61K2300/00
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7.发明公开
公开(公告)号：EP2246056A1
公开(公告)日：2010-11-03
申请号：EP09706367.1
申请日：2009-01-29
发明人： ISHIDA, Tatsuhiro , KIWADA, Hiroshi
IPC分类号： A61K31/513 , A61K9/127 , A61K31/282 , A61K31/4412 , A61K31/53 , A61K47/24 , A61K47/34 , A61P35/00 , A61P43/00
CPC分类号： A61K31/282 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/555 , A61K2300/00
摘要： An object of the present invention is to further enhance the antitumor effect when oxaliplatin is administered in combination with a combination drug containing tegafur, gimeracil and oteracil potassium. According to the present invention, by using oxaliplatin encapsulated in a liposome preparation, combination therapy of oxaliplatin plus a combination drug containing tegafur, gimeracil and oteracil potassium, is revealed to show remarkably enhanced antitumor effect without increasing side effects.
摘要翻译： 本发明的一个目的是当奥沙利铂联合给药与组合药物含有替加氟，吉莫斯特和氧嗪酸钾つweiterer增强抗肿瘤效果。 。根据本发明，通过使用奥沙利铂封装在脂质体制剂，奥沙利铂的组合治疗加组合药物含有替加氟，吉莫斯特和氧嗪酸钾，显露显示显着增强的抗肿瘤效果，而不增加副作用。
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8.发明授权
公开(公告)号：EP2883542B1
公开(公告)日：2019-05-01
申请号：EP13827386.7
申请日：2013-08-09
发明人： DOI, Yusuke , ISHIDA, Tatsuhiro
IPC分类号： A61K31/282 , A61K9/127 , A61K47/22 , A61K47/24 , A61K45/06 , A61K31/555
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