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公开(公告)号：EP3463071A1
公开(公告)日：2019-04-10
申请号：EP17809491.8
申请日：2017-06-05
申请人： Endra, Inc. , Thornton, Michael M.
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公开(公告)号：EP1356032A2
公开(公告)日：2003-10-29
申请号：EP01955908.7
申请日：2001-07-20
发明人： YUE, Henry , KHAN, Farrah, A. , GURURAJAN, Rajagopal , HAFALIA, April, J., A. , CHAWLA, Narinder K. , ARVIZU, Chandra S. , RAMKUMAR, Jayalaxmi , GANDHI, Ameena, R. , POLICKY, Jennifer, L. , BAUGHN, Mariah, R. , TRIBOULEY, Catherine, M. , BANDMAN, Olga , NGUYEN, Danniel, B. , LU, Yan , BURFORD, Neil , LAL, Preeti , DING, Li , YAO, Monique, G. , ELLIOTT, Vicki, S. , RECIPON, Shirley, A. , KEARNEY, Liam , LU, Dyung, Aina, M. , GREENWALD, Sara, R. , TANG, Y., Tom , XU, Yuming , WALSH, Roderick, T. , GIETZEN, Kimberly, J. , YANG, Junming , JACKSON, Jennifer, L. , THORNTON, Michael
CPC分类号： C12N9/1205
摘要： The invention provides human human kinases (PKIN) and polynucleotides which identify and encode PKIN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associatedd withd abberant expression of PKIN.
摘要翻译： 本发明提供了鉴定和编码PKIN的人类人类激酶（PKIN）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与PKIN异常表达相关的疾病的方法。
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公开(公告)号：EP3328285A1
公开(公告)日：2018-06-06
申请号：EP16832013.3
申请日：2016-07-29
申请人： Endra, Inc. , Thornton, Michael M.
摘要： A method for correcting fat-induced aberrations in ultrasound imaging comprises segmenting a thermoacoustic absorption image of a region of interest into at least one fat region and at least one non-fat region, creating a speed of sound map by assigning a speed of sound to each region based on tissue type of the region, correcting aberrations in the segmented thermoacoustic absorption image using the assigned speeds of sound thereby generating a corrected thermoacoustic image, and correcting an ultrasound image of the region of interest using the corrected thermoacoustic image and the speed of sound map.
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公开(公告)号：EP3294142A1
公开(公告)日：2018-03-21
申请号：EP16791873
申请日：2016-05-13
申请人： ENDRA INC , THORNTON MICHAEL M
发明人： THORNTON MICHAEL M , PICOT PAUL A
CPC分类号： A61B5/0095 , A61B8/14 , A61B8/4416 , A61B8/4494
摘要： Combined transducer arrays for imaging features of tissue include a transducer array configured for transmit-receive ultrasound imaging, and a transducer array configured for receive-only thermoacoustic imaging. The transmit-receive transducer array includes a plurality of transmit-receive array elements, and the receive-only transducer array includes a plurality of receive-only array elements. The receive-only array elements are registered with and surround the transmit-receive array elements. The receive-only transducer array and transmit-receive transducer array may be housed in an ultrasound probe. The combined transducer arrays may be used in composite imaging of tissue, based on the registration of the transmit-receive array elements and the receive-only array elements. Registration of the transmit-receive array and the receive-only array may involve physical alignment or proximity of these transducer arrays, and may use data representative of known geometry and positions of elements of the two arrays in reconstructing respective images (ultrasound and thermoacoustic) in composite imaging.
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公开(公告)号：EP3328285B1
公开(公告)日：2020-07-22
申请号：EP16832013.3
申请日：2016-07-29
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公开(公告)号：EP3294142B1
公开(公告)日：2020-10-21
申请号：EP16791873.9
申请日：2016-05-13
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公开(公告)号：EP3294143A1
公开(公告)日：2018-03-21
申请号：EP16791874
申请日：2016-05-13
申请人： ENDRA INC , THORNTON MICHAEL M
发明人： THORNTON MICHAEL M , PICOT PAUL A
CPC分类号： A61B5/0093 , A61B5/0035 , A61B5/0095 , A61B8/14 , A61B8/145 , A61B8/42 , A61B8/4416 , A61B8/4477 , A61B8/4483 , A61B8/4494 , A61B8/5261
摘要： A thermoacoustic imaging system is provided for use in combination with an ultrasound imaging system for imaging features of tissue, the ultrasound imaging system including an ultrasound imaging probe including a transmit-receive transducer array with a plurality of transmit-receive array elements. The thermoacoustic imaging system includes a receive-only transducer array with a plurality of receive-only array elements, registered with the plurality of transmit-receive array elements. The transmit-receive transducer array is housed in an ultrasound imaging probe, and the receive-only transducer array is housed in a thermoacoustic imaging probe. The thermoacoustic imaging probe is mechanically joined to the ultrasound imaging probe, e.g., as a sleeve fitted to the ultrasound imaging probe. A combined ultrasound transducer system including the ultrasound imaging probe and an thermoacoustic imaging probe may be used in composite imaging of tissue based upon the registration of the receive-only array elements with the transmit-receive array elements.
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