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1.发明授权
公开(公告)号：EP1592789B1
公开(公告)日：2009-05-20
申请号：EP03800225.9
申请日：2003-12-24
申请人： TransGenRx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12N15/00 , C12N15/63 , C12P21/00 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A23L15/00 , A23V2002/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/62 , C07K16/00 , C07K16/02 , C07K16/1063 , C07K16/26 , C07K2317/23 , C07K2317/34 , C12N15/85 , C12N2800/90 , C12N2830/003 , C12N2830/008 , C12N2830/90 , C12N2840/20 , Y02A50/407 , Y02A50/469 , A23V2300/21
摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
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2.发明公开
公开(公告)号：EP1592789A2
公开(公告)日：2005-11-09
申请号：EP03800225.9
申请日：2003-12-24
申请人： Transgenrx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12N15/00 , C12N15/63 , C12P21/00 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A23L15/00 , A23V2002/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/62 , C07K16/00 , C07K16/02 , C07K16/1063 , C07K16/26 , C07K2317/23 , C07K2317/34 , C12N15/85 , C12N2800/90 , C12N2830/003 , C12N2830/008 , C12N2830/90 , C12N2840/20 , Y02A50/407 , Y02A50/469 , A23V2300/21
摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
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公开(公告)号：EP2342224A2
公开(公告)日：2011-07-13
申请号：EP09815462.8
申请日：2009-09-25
申请人： TransGenRx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C07K14/555 , C12N15/63 , C07H21/04 , C12P21/06
CPC分类号： C07K14/555 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C07K14/465 , C07K2319/43 , C07K2319/50 , C12N15/85 , C12N15/8509 , C12N2800/90 , C12N2830/15 , C12N2830/40 , C12N2830/46 , C12N2830/60 , C12N2830/90 , C12N2840/105
摘要： Novel compositions for the production of interferons such as interferon-α 2a, interferon-α 2b, or interferon-β 1a (IFN-α 2a, IFN-α 2b, or IFN-β 1a) are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes an interferon such as IFN-α 2a, IFN-α 2b, or IFN-β 1a, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of an interferon such as IFN-α 2a, IFN-α 2b, or IFN-β 1a.
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公开(公告)号：EP1597378A2
公开(公告)日：2005-11-23
申请号：EP03808563.5
申请日：2003-12-24
申请人： Transgenrx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12P21/00 , A01K67/027 , A01K67/033 , C07H21/04 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A23L15/00 , A23V2002/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/62 , C07K16/00 , C07K16/02 , C07K16/1063 , C07K16/26 , C07K2317/23 , C07K2317/34 , C12N15/85 , C12N2800/90 , C12N2830/003 , C12N2830/008 , C12N2830/90 , C12N2840/20 , Y02A50/407 , Y02A50/469 , A23V2300/21
摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
摘要翻译： 本发明提供了一种在个体中产生多聚体蛋白质的新的，有效的和有效的方法。 多聚体蛋白质包括相关的多聚体蛋白质（两种或更多种相关多肽）和多价多聚体蛋白质（由多于一种目的基因编码的单一多肽）。 个体中多聚蛋白的表达和/或形成是通过将含有编码部分多聚蛋白的感兴趣基因的多核苷酸盒给予个体来实现的。 多核苷酸盒可另外含有一个或多个pro序列，prepro序列，cecropin前原序列和/或切割位点序列。
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公开(公告)号：EP0804219B1
公开(公告)日：2002-07-17
申请号：EP95913576.5
申请日：1995-02-28
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K9/00 , C07K14/00 , C07K17/00 , A61K39/385 , C07K14/575
CPC分类号： C07K14/575 , A01K2217/05 , A61K39/0005 , A61K2039/6068 , C07K2319/00
摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.
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公开(公告)号：EP0804219A1
公开(公告)日：1997-11-05
申请号：EP95913576.0
申请日：1995-02-28
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12N15 , A61K35 , A61K38 , A61K39 , A61P15 , C07H21 , C07K9 , C07K14 , C07K17 , C07K19 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/575 , A01K2217/05 , A61K39/0005 , A61K2039/6068 , C07K2319/00
摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.
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公开(公告)号：EP0833658B1
公开(公告)日：2003-03-26
申请号：EP96918234.4
申请日：1996-06-06
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K2039/6068 , C07K14/575 , C07K2319/00
摘要： The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.
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公开(公告)号：EP0833658A1
公开(公告)日：1998-04-08
申请号：EP96918234.0
申请日：1996-06-06
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K2039/6068 , C07K14/575 , C07K2319/00
摘要： The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.
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