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公开(公告)号：EP2675487B1
公开(公告)日：2018-10-17
申请号：EP12755058.0
申请日：2012-02-09
申请人： Bovin, Nicolai Vladimirovich , Henry, Stephen Micheal , Korchagina, Elena Yurievna , Rodionov, Igor Leonidovich , Tuzikov, Alexander Borisovich
发明人： Bovin, Nicolai Vladimirovich , Henry, Stephen Micheal , Korchagina, Elena Yurievna , Rodionov, Igor Leonidovich , Tuzikov, Alexander Borisovich
CPC分类号： C07K7/08 , A61K51/0408 , A61K51/08 , A61K51/088 , C07F9/10
摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
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2.发明公开IN VIVO METHODS OF MONITORING BIODISTRIBUTION 审中-公开INVIVO-VERFAHREN ZURÜBERWACHUNGEINER BIOVERTEILUNG
公开(公告)号：EP2675487A1
公开(公告)日：2013-12-25
申请号：EP12755058.0
申请日：2012-02-09
申请人： Bovin, Nicolai Vladimirovich , Henry, Stephen Micheal , Korchagina, Elena Yurievna , Rodionov, Igor Leonidovich , Tuzikov, Alexander Borisovich
发明人： Bovin, Nicolai Vladimirovich , Henry, Stephen Micheal , Korchagina, Elena Yurievna , Rodionov, Igor Leonidovich , Tuzikov, Alexander Borisovich
CPC分类号： C07K7/08 , A61K51/0408 , A61K51/08 , A61K51/088 , C07F9/10
摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
摘要翻译： 公开了结构F-S-L的功能 - 脂质构建体，其中F包含酪氨酸或组氨酸残基，S是共价连接F与L并且L是脂质的间隔基。 功能性残基可以被碘化并用于用1251放射性标记生物实体，碘化构建体用于监测生物体在体内分布的非侵入性方法。
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公开(公告)号：EP2350120A1
公开(公告)日：2011-08-03
申请号：EP08877373.4
申请日：2008-10-13
申请人： Bovin, Nikolai Vladimirovich , Chinarev, Alexandr Alexandrovich , Tuzikov, Alexander Borisovich
发明人： Bovin, Nikolai Vladimirovich , Chinarev, Alexandr Alexandrovich , Tuzikov, Alexander Borisovich
CPC分类号： C07K9/001 , A61K47/641 , C07H15/04 , C07H15/26 , C07K9/00
摘要： Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications.
摘要翻译： 多配体构建体和中间多价构建体用于其制备。 多配体结构在诊断和治疗应用中具有实用性。
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公开(公告)号：EP3221337A4
公开(公告)日：2018-05-02
申请号：EP15860430
申请日：2015-11-23
申请人： BOVIN NICOLAI VLADIMIROVICH , HENRY STEPHEN MICHEAL , KORCHAGINA ELENA YURIEVNA , RODIONOV IGOR LEONIDOVICH , TUZIKOV ALEXANDER BORISOVICH
发明人： BOVIN NICOLAI VLADIMIROVICH , HENRY STEPHEN MICHEAL , KORCHAGINA ELENA YURIEVNA , RODIONOV IGOR LEONIDOVICH , TUZIKOV ALEXANDER BORISOVICH
IPC分类号： C07K14/00 , A61K31/683 , A61K31/7004 , A61K31/702 , A61K38/16 , C07F9/10 , C07H15/04 , C07K7/06 , C07K7/08
CPC分类号： C07K9/00 , A61K31/685 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K38/00 , A61K47/555 , C07K7/06 , C07K7/08 , C07K14/001
摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
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公开(公告)号：EP3221337A1
公开(公告)日：2017-09-27
申请号：EP15860430.6
申请日：2015-11-23
申请人： Bovin, Nicolai Vladimirovich , Henry, Stephen Micheal , Korchagina, Elena Yurievna , Rodionov, Igor Leonidovich , Tuzikov, Alexander Borisovich
发明人： Bovin, Nicolai Vladimirovich , Henry, Stephen Micheal , Korchagina, Elena Yurievna , Rodionov, Igor Leonidovich , Tuzikov, Alexander Borisovich
IPC分类号： C07K14/00 , C07H15/04 , C07F9/10 , A61K38/16 , A61K31/683 , A61K31/7004 , A61K31/702
CPC分类号： C07K9/00 , A61K31/685 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K38/00 , A61K47/555 , C07K7/06 , C07K7/08 , C07K14/001
摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
摘要翻译： 公开了自发并稳定地结合到膜中的水分散性多价配体 - 脂质构建体。
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公开(公告)号：EP2675487A4
公开(公告)日：2016-05-18
申请号：EP12755058
申请日：2012-02-09
申请人： BOVIN NICOLAI VLADIMIROVICH , HENRY STEPHEN MICHEAL , KORCHAGINA ELENA YURIEVNA , RODIONOV IGOR LEONIDOVICH , TUZIKOV ALEXANDER BORISOVICH
发明人： BOVIN NICOLAI VLADIMIROVICH , HENRY STEPHEN MICHEAL , KORCHAGINA ELENA YURIEVNA , RODIONOV IGOR LEONIDOVICH , TUZIKOV ALEXANDER BORISOVICH
CPC分类号： A61K51/08 , A61K51/0408 , A61K51/088 , C07F9/10 , C07K7/08
摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
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