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公开(公告)号：EP3149704B1
公开(公告)日：2018-08-01
申请号：EP15727058
申请日：2015-05-29
IPC分类号： G06T7/00
CPC分类号： G06T7/0044 , G06T7/74 , G06T2207/10004 , G06T2207/10021 , G06T2207/10048 , G06T2207/20081 , G06T2207/30244 , G06T2207/30252
摘要： A method of localising a transportable apparatus (102) within an environment around the apparatus is disclosed. The method comprises obtaining a sequence of images (200) of the environment and generating one or more sequences of transformed images (204) from the sequence of images wherein an image from the sequence of images has undergone a transformation to provide a transformed image within the sequence of transformed images. Processing circuitry (112) is then used to compare one or more images from the sequence of transformed images (204) and one or more images from at least one of the sequence of images (200) and a further sequence of transformed images against a representation of the environment. The comparison determines corresponding features within the images (200) and/or transformed images (204) and the representation. The transportable apparatus (102) is then localised according to a position of the one or more corresponding features.
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公开(公告)号：EP3182124A1
公开(公告)日：2017-06-21
申请号：EP17153845
申请日：2011-12-21
发明人： VYAS PARESH , GOARDON NICOLAS , FREEMAN SYLVIE
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/5011 , G01N33/57426 , G01N2333/70589 , G01N2333/70596
摘要： The present invention relates to a method for diagnosis of acute myeloid leukaemia comprising: i. contacting an isolated sample containing a blood cell population with a screen that detects at least the following cell surface polypeptide markers: CD34 + ; CD45RA + ; CD123 + ; and CD38 - ; wherein (+) indicates the presence and (-) indicates the absence of said cell surface polypeptide markers; and ii. confirming the presence of a blood cell that has a cell surface phenotype comprising: a. CD34 + ; b. CD45RA + ; c. CD123 + ; and d. CD38 - . Also encompassed are related methods for prognosis, identifying a therapeutic candidate, and monitoring efficacy of a therapeutic molecule.
摘要翻译： 本发明涉及一种诊断急性骨髓性白血病的方法，其包括：i。 使含有血细胞群的分离的样品与检测至少下列细胞表面多肽标记物的筛选物接触：CD34 +; CD45RA +; CD123 +; 和CD38 - ; 其中（+）表示存在并且（ - ）表示不存在所述细胞表面多肽标记; 和ii。 证实具有细胞表面表型的血细胞的存在，所述血细胞包含：a。 CD34 +; 湾 CD45RA +; C。 CD123 +; 和d。 CD38 - 。 还包括用于预后，鉴定治疗候选物和监测治疗分子的功效的相关方法。
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公开(公告)号：EP2965321B1
公开(公告)日：2017-05-03
申请号：EP14713565
申请日：2014-03-06
发明人： VENTIKOS YIANNIS , HAWKER NICHOLAS
IPC分类号： G21B3/00
摘要： A method of producing a localised concentration of energy includes: creating a shockwave propagating through a non-gaseous medium so as to be incident upon a boundary between the non-gaseous medium and a gaseous medium formed by at least one hole in a barrier separating the non-gaseous medium from a gaseous medium. This forms a transverse jet on the other side of the hole which is incident upon a target surface comprising a depression which is spaced from the barrier in the gaseous medium. An apparatus for producing a localised concentration of energy is also described.
摘要翻译： 产生能量的局部集中的方法包括：产生通过非气体介质传播的冲击波，以便入射在非气体介质与由隔离物中的至少一个孔形成的气体介质之间的边界上， 来自气态介质的非气态介质。 这在孔的另一侧上形成横向射流，该射流入射到目标表面上，该目标表面包括与气体介质中的隔离件隔开的凹陷。 还描述了用于产生局部能量集中的装置。
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公开(公告)号：EP3286691A1
公开(公告)日：2018-02-28
申请号：EP16718869
申请日：2016-04-21
发明人： POSNER INGMAR , WANG ZENG
CPC分类号： G06K9/00214 , G06K9/6203
摘要： Objects within a three-dimensional (3D) environment are detected by obtaining a point-cloud environment representation (e.g. from LIDAR) comprising a set of point locations, and converting the point-cloud to a 3D feature grid by dividing the 3D space into cells according to a grid size, determining whether the cells contain point-cloud points, and mapping any that do to a feature vector, and mapping any that do not to a zero feature vector. A detection window is also generated containing an integral number of the cells and having a set of positions which can be occupied. A detection score for each position is calculated by: voting for each cell within the window which includes at least one point, each vote being calculated using the cell feature vector (e.g. fixed-dimensional feature vector) and a weighting vector (e.g. obtained from a linear classifier), and summing the votes. The score provides a basis for determining whether each position contains an object of interest, each position with a score above a threshold being classified as containing an object of interest. The vote may comprise a scalar product of the cells feature vector and the weighting vector. A system performing the method may be provided on a vehicle.
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公开(公告)号：EP2965322B1
公开(公告)日：2017-05-03
申请号：EP14714769
申请日：2014-03-06
IPC分类号： G21B3/00
摘要： A method of producing a localised concentration of energy includes: creating at least one shockwave propagating through a non-gaseous medium so as first to be incident upon a focusing pocket of fluid within the medium. The focusing pocket of fluid is positioned relative to a differently sized target pocket of gas within the medium, and is arranged to shield the target pocket of gas from the initial shockwave, such that the incidence of the shockwave on the focusing pocket of fluid concentrates the intensity of a shockwave subsequently incident upon the target pocket of gas. An apparatus for producing a localised concentration of energy is also described.
摘要翻译： 产生局部能量集中的方法包括：产生至少一个冲击波，该冲击波通过非气体介质传播，以便首先入射到介质内的流体的聚焦袋上。 流体的聚焦袋相对于介质内的不同尺寸的气体目标袋被定位，并且被布置成屏蔽来自初始冲击波的气体的目标袋，使得冲击波在流体的聚焦袋上的入射集中 随后入射在气体目标袋上的冲击波强度。 还描述了用于产生局部能量集中的装置。
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公开(公告)号：EP3294331A1
公开(公告)日：2018-03-21
申请号：EP16723813
申请日：2016-05-11
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/51 , A61K2039/5258 , A61K2039/545 , C12N2710/10023 , C12N2770/24134
摘要： The invention relates to a protein comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across all four dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4, and wherein the conserved sequences comprise at least part of a sequence of one or more non-structural proteins of the dengue virus serotypes. The invention further relates to associated peptides, compositions,nucleic acids, viral vectors, virus- like particles, use,prime boost vaccination kits, agents and methods.
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公开(公告)号：EP3286594A2
公开(公告)日：2018-02-28
申请号：EP16718898
申请日：2016-04-25
发明人： KAPANIDIS ACHILLEFS , JING BO
CPC分类号： G02B21/24 , G02B21/16 , G02B21/361 , G02B21/362
摘要： A compact microscope comprising an enclosure,a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, a sample stage supported on the primary optical support element to support a sample, a return optical system to receive returned light from a sample and transmit returned light to a detection apparatus, wherein the return optical system is mounted on the primary optical support element, and wherein the compact microscope comprises at least one of the following elements; a) an objective lens system, the objective lens system being supported on the primary optical support element, an illumination section and an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a mirror disposed above the sample stage, the illumination optical system being arranged to direct light through the objective lens system to the mirror; b) a temperature-control system, the temperature control system comprising a temperature control circuit comprising a plurality of fluid-carrying channels within at least one of the enclosure and the primary optical support element; and c) the return optical system being operable to separate returned light into at least a first wavelength band and a second wavelength band, and the detection apparatus comprising an imaging apparatus, the return optical system having a first tube lens to focus returned light in a first wavelength band to a first area of the imaging apparatus and a second tube lens to focus returned light in a second wavelength band to a second area of the imaging apparatus.
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公开(公告)号：EP3285651A1
公开(公告)日：2018-02-28
申请号：EP16721494
申请日：2016-04-25
发明人： HAMILTON THOMAS , MURRAY DAVID , MELLON STEPHEN , PANDIT HEMANT
IPC分类号： A61B6/04
CPC分类号： A61B6/50 , A61B5/4528 , A61B6/0421 , A61B6/0485 , A61G13/1245
摘要： A patient positioning apparatus for use with a medical imaging device, the patient positioning apparatus comprising a first element and a second element, the first element having a base part and an upper part to engage a knee joint of the patient, the second element comprising a lower leg engagement part to receive a lower leg of the patient to maintain the lower leg in a desired position.
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9.发明授权MAPPING AND CHARACTERIZATION OF CAVITATION ACTIVITY 有权KARTIERUNG UND CHARAKTERISIERUNG VONKAVITITATIONSAKTIVITÄT
公开(公告)号：EP2349483B1
公开(公告)日：2017-05-03
申请号：EP09774917
申请日：2009-11-04
CPC分类号： A61B8/08 , A61B2017/00106 , A61B2017/22008 , A61B2090/378 , A61N7/00 , A61N7/02 , A61N2007/0052
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10.发明公开MOSAIC CONSERVED REGION HIV IMMUNOGENIC POLYPEPTIDES 审中-公开HIV-IMMUNOGEN-POLYPEPTID MIT KONSERVIERTEN MOSAIKREGIONEN
公开(公告)号：EP3052517A4
公开(公告)日：2017-07-26
申请号：EP14846993
申请日：2014-09-30
发明人： KORBER BETTE T M , HANKE TOMAS , MCMICHAEL ANDREW
CPC分类号： A61K39/21 , A61K39/12 , C07K14/005 , C12N2740/16034
摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
摘要翻译： 本文公开了马赛克保守区HIV多肽和免疫原性多肽，包括一个或多个马赛克保守区多肽。 在一些实施方案中，免疫原性多肽包含在免疫原性组合物中，例如多价免疫原性组合物。 本文还公开了用于治疗或抑制受试者中的HIV的方法，其包括将一种或多种所公开的免疫原性多肽或组合物给予患有HIV感染或具有感染HIV风险的受试者。 在一些实施方案中，所述方法包括在受试者中诱导免疫应答，包括向受试者施用至少一种所公开的免疫原性多肽或编码至少一种免疫原性多肽的核酸。
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