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    MR IMAGING DIAGNOSTIC AGENT FOR INTRACTABLE NEUROLOGICAL DISEASE
    1.
    发明公开
    MR IMAGING DIAGNOSTIC AGENT FOR INTRACTABLE NEUROLOGICAL DISEASE 审中-公开
    MR-BILDGEBUNGS-DIAGNOSTIKUMFÜRSCHWER BEHANDELBARE神经病学ERKRANKUNGEN

    公开(公告)号：EP2944626A4

    公开(公告)日：2016-09-14

    申请号：EP14737825

    申请日：2014-01-06

    申请人： UNIV SHIGA MEDICAL SCIENCE

    发明人： TOOYAMA IKUO ,  TAGUCHI HIROYASU ,  YANAGISAWA DAIJIRO

    IPC分类号： A61K49/12 ,  A61P25/28 ,  C07C235/34 ,  C07D263/56

    CPC分类号： A61K49/126 ,  A61K49/085 ,  C07C235/34 ,  C07D235/14 ,  C07D263/56 ,  G01N33/6896 ,  G01N2333/4709

    摘要： Disclosed is a compound represented by formula (1) or a salt thereof, formula (1) : wherein X is a residue of a compound having activity of binding to at least one member selected from the group consisting of amyloid ² proteins, tau proteins, ±-synuclein, and TDP-43; m is an integer of 0 to 6; n is an integer of 1 to 5; and J is a group selected from the group consisting of wherein R 1 and R 2 are each independently a hydrogen atom, a fluorine atom, methyl, or trifluoromethyl; R 3 is trifluoromethyl or trifluoromethoxy; and p is an integer of 1 to 4, provided that m + n ‰¥ 5 when J is J-1, and m + n ‰¥ 7 when J is J-2 or J-3.

    摘要翻译： 公开了由式（1）表示的化合物或其盐，式（1）：其中X是具有与选自淀粉样蛋白2蛋白，tau蛋白， ± - 突触核蛋白和TDP-43; m为0〜6的整数; n为1〜5的整数， 并且J是选自其中R 1和R 2各自独立地为氢原子，氟原子，甲基或三氟甲基的基团; R 3是三氟甲基或三氟甲氧基; p为1〜4的整数，J为J-1时m + n‰¥5，J为J-2或J-3时为m + n‰。

    ANTI-ADHESION MATERIAL
    7.
    发明公开
    ANTI-ADHESION MATERIAL 有权
    ANTIADHÄSIONSMATERIAL

    公开(公告)号：EP2522374A4

    公开(公告)日：2014-07-09

    申请号：EP10841018

    申请日：2010-12-27

    申请人： KAWASUMI LAB INC ,  UNIV SHIGA MEDICAL SCIENCE

    发明人： TANI TORU ,  KAMITANI SUMIHIRO ,  MUKAI TOMOKAZU

    IPC分类号： A61L31/00 ,  A61L15/64

    CPC分类号： A61L31/10 ,  A61L31/148 ,  Y10T428/24942 ,  Y10T428/265 ,  Y10T428/31786

    摘要： An object of the present invention is to provide an anti-adhesion material having sufficient in vivo degradability and excellent anti-adhesion characteristics, and also superior to conventional ones in terms of handling properties under wet conditions. The anti-adhesion material (1) of the present invention has a sheet-like base layer (10) containing a water soluble polymer (e.g., pullulan), a first cover layer (20) placed on a surface on one side of the base layer (10) and containing an aliphatic ester, and a second cover layer (30) placed on a surface on the other side of the base layer (10) and containing an aliphatic ester. The optical thickness of each of the first cover layer (20) and the second cover layer (30) is set to be 27 nm or greater and smaller than 160 nm.