公开(公告)号：EP2944626A4

公开(公告)日：2016-09-14

申请号：EP14737825

申请日：2014-01-06

申请人： UNIV SHIGA MEDICAL SCIENCE

发明人： TOOYAMA IKUO ,  TAGUCHI HIROYASU ,  YANAGISAWA DAIJIRO

IPC分类号： A61K49/12 ,  A61P25/28 ,  C07C235/34 ,  C07D263/56

CPC分类号： A61K49/126 ,  A61K49/085 ,  C07C235/34 ,  C07D235/14 ,  C07D263/56 ,  G01N33/6896 ,  G01N2333/4709

摘要： Disclosed is a compound represented by formula (1) or a salt thereof, formula (1) : wherein X is a residue of a compound having activity of binding to at least one member selected from the group consisting of amyloid ² proteins, tau proteins, ±-synuclein, and TDP-43; m is an integer of 0 to 6; n is an integer of 1 to 5; and J is a group selected from the group consisting of wherein R 1 and R 2 are each independently a hydrogen atom, a fluorine atom, methyl, or trifluoromethyl; R 3 is trifluoromethyl or trifluoromethoxy; and p is an integer of 1 to 4, provided that m + n ‰¥ 5 when J is J-1, and m + n ‰¥ 7 when J is J-2 or J-3.

摘要翻译： 公开了由式（1）表示的化合物或其盐，式（1）：其中X是具有与选自淀粉样蛋白2蛋白，tau蛋白， ± - 突触核蛋白和TDP-43; m为0〜6的整数; n为1〜5的整数， 并且J是选自其中R 1和R 2各自独立地为氢原子，氟原子，甲基或三氟甲基的基团; R 3是三氟甲基或三氟甲氧基; p为1〜4的整数，J为J-1时m + n‰¥5，J为J-2或J-3时为m + n‰。