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公开(公告)号：EP3117367B1
公开(公告)日：2018-10-31
申请号：EP15703792.0
申请日：2015-02-12
发明人： PAARUP KYLLING, Anton , BERNTSEN, Jørgen , RAMSING, Niels , PORSGAARD, Søren , QVISTGAARD KAJHØJ, Tine , BERGHOLD KUHLMANN, Reidun
CPC分类号： G06T7/0016 , C12M21/06 , C12M41/46 , G06F3/00 , G06K9/4671 , G06K9/6215 , G06K9/66 , G06T7/246 , G06T11/60 , G06T2207/10016 , G06T2207/30044
摘要： Apparatus and methods for helping a user establish values (e.g. timings) for a plurality of parameters of interest (e.g. cell divisions) relating to the development of an embryo from a series of images of the embryo are described. For each parameter of interest an image is selected for display to a user seeking to establish a value for the parameter of interest. For example, the selected image may be an image predicted to be an image reflecting the value for the parameter of interest. For example, the selected image may be based on a calculated timing for a particular developmental event. The timing may be calculated from a numerical analysis of the images or maybe predetermined. If the user is unable to determine a value for the parameter of interest from the selected image, the user may scroll through neighbouring images until the user can determine a value for the parameter of interest. A value for the proud of interest may then be established in response to user input, for example a user providing an indication that a timing associated with a currently displayed image from the series of images should be taken to be the value of the parameter of interest. The different parameters of interest may be established in an iterative manner in which an initial image for display to a user is selected for each parameter of interest based on the parameter of interest.
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公开(公告)号：EP3140389A1
公开(公告)日：2017-03-15
申请号：EP15711774.8
申请日：2015-03-24
发明人： MADSEN, Kim Bøndergaard , HANSEN, Jonas Lerche , PORSGAARD, Søren , RAMSING, Niels , BERNTSEN, Jørgen
摘要： A culture dish for holding one or more object to be cultured is described. The culture dish has a main body comprising at least one well for receiving an object to be cultured and a quantity of culturing media for the object, such as a water-based growth media, and a reservoir for receiving a quantity of cover media, such as mineral oil. The at least one well is provided in a floor of the reservoir so that when in normal use cover media in the reservoir overlays culturing media in the at least one well. The reservoir is defined by the reservoir floor and a reservoir wall extending away from the reservoir floor. At least a section of the reservoir wall is angled away from the vertical so as to be inclined with respect to a horizontal plane defined by a surface of cover media in the reservoir when the culture dish is in normal use. The angled section of the reservoir wall can help reduce the appearance of a meniscus in the cover media overlaying the wells, and can furthermore be positioned so as to provide a ready indication of when the reservoir contains an appropriate level of cover media for culturing.
摘要翻译： 描述了用于保持一个或多个待培养物体的培养皿。 培养皿具有主体，该主体包括用于接收待培养物体的至少一个孔和用于该目标的培养基的量，诸如水基生长培养基，以及用于接收一定量的覆盖培养基的储存器，诸如 作为矿物油。 所述至少一个井设置在所述储存器的地板中，以便当正常使用时，所述储存器中的覆盖介质覆盖所述至少一个井中的培养介质。 储存器由储存器底板和远离储存器底板延伸的储存器壁限定。 当培养皿处于正常使用状态时，储存器壁的至少一部分与竖直方向成角度地倾斜，以相对于由储存器中的盖子介质的表面限定的水平面倾斜。 储存器壁的倾斜部分可以帮助减少覆盖在井上的覆盖介质中的弯液面的外观，并且可以进一步定位以提供储存器何时包含用于培养的适当水平的覆盖介质的准备指示。
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公开(公告)号：EP2315823A2
公开(公告)日：2011-05-04
申请号：EP09776231.4
申请日：2009-07-03
IPC分类号： C12M1/18
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.
摘要翻译： 本发明涉及一种用于辅助细胞的安全处理的系统，以便最小化处理导致细胞样品混合的错误的风险。 该系统允许在整个培养期间对细胞进行一对一鉴定。 这是通过为培养系统提供装载/出口控制装置获得的，其确保每次只能够装载/移除一个装置。
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公开(公告)号：EP3102667A1
公开(公告)日：2016-12-14
申请号：EP15700232.0
申请日：2015-01-13
发明人： RAMSING, Niels , LERCHE HANSEN, Jonas , BØNDERGAARD MADSEN, Kim , KOFOED MEJER, Troels , BERNTSEN, Jørgen
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/50 , C12M25/00 , C12M41/14 , C12M41/36 , C12M41/46 , C12M41/48
摘要： Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a sample platform comprising a plurality of receptacles for holding embryos within the incubation chamber for incubation. The sample platform may comprise a slide carrier on which embryo slides containing the receptacles may be placed incubation. The sample platform is rotatable about a rotation axis relative to the incubation chamber housing so as to allow receptacles to be selectively rotated to a monitoring position that is aligned with a viewing port provided in the incubation chamber housing, for example an opening or window. An imaging device is located outside the incubation chamber and arranged to image embryos within the incubation chamber at the monitoring position through the viewing port.
摘要翻译： 描述了用于监测培养箱中胚胎的装置和方法。 该装置包括由孵育室壳体和样品平台限定的孵育室，样品平台包括多个容纳器，用于将胚胎保持在孵育室内用于孵育。 样品平台可以包括载玻片载体，载玻片载体可以在其上放置容纳接收器的胚胎载玻片。 样品平台可相对于孵育室壳体围绕旋转轴线旋转，以便允许容器选择性地旋转到与设置在孵育室壳体（例如开口或窗口）中的观察口对准的监测位置。 成像装置位于孵育室外部并且被布置成通过观察口将监测位置处的孵育室内的胚胎成像。
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公开(公告)号：EP3102663A1
公开(公告)日：2016-12-14
申请号：EP15700656.0
申请日：2015-01-13
发明人： RAMSING, Niels , BØNDERGAARD MADSEN, Kim , LERCHE HANSEN, Jonas , KOFOED MEJER, Troels , BERNTSEN, Jørgen
摘要： Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a slide carrier comprising a plurality of compartment walls that define compartments for holding embryo slides within the incubation chamber for incubation. The slide carrier is moveable, for example by rotation, relative to the incubation chamber housing to allow a selected compartment to be moved to a loading position defined at least in part by a loading port wall associated with the incubation chamber housing. The loading port wall is arranged to cooperate with the wall of a compartment in the loading position to restrict the extent to which the environment of the compartment in the loading position is in fluid communication with the environments of other compartments in the incubation chamber.
摘要翻译： 描述了用于监测培养箱中胚胎的装置和方法。 该装置包括由孵育室壳体和包含多个隔室壁的载玻片载体限定的孵育室，该多个隔室壁限定用于保持孵育室内的胚胎载玻片用于孵育的隔室。 载玻片可相对于培育室壳体移动，例如通过旋转，以允许选定的室移动到至少部分由与培育室壳体相关的装载口壁限定的装载位置。 装载口壁布置成与装载位置中的隔室的壁配合以限制装载位置中的隔室的环境与培养室中的其他隔室的环境流体连通的程度。
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6.发明公开EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE DIVISION AND MOVEMENT 无效胚胎质量评估基于BLASTOMERENTEILUNG和运动
公开(公告)号：EP2035548A2
公开(公告)日：2009-03-18
申请号：EP07722668.6
申请日：2007-06-15
CPC分类号： C12Q1/02 , A61B17/435 , C12M21/06 , C12M41/46 , C12M41/48 , C12N5/0604 , G01N33/689 , G01N2800/385
摘要： The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.
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公开(公告)号：EP3102663B1
公开(公告)日：2020-04-22
申请号：EP15700656.0
申请日：2015-01-13
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公开(公告)号：EP2315823B1
公开(公告)日：2018-03-07
申请号：EP09776231.4
申请日：2009-07-03
IPC分类号： C12M1/18
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.
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9.发明公开METHODS AND APPARATUS FOR ANALYSING EMBRYO DEVELOPMENT 审中-公开VERFAHREN UND VORRICHTUNG ZUR ANALYZE DER ENTWICKLUNG EINES EMBRYOS
公开(公告)号：EP3117367A1
公开(公告)日：2017-01-18
申请号：EP15703792.0
申请日：2015-02-12
发明人： PAARUP KYLLING, Anton , BERNTSEN, Jørgen , RAMSING, Niels , PORSGAARD, Søren , QVISTGAARD KAJHØJ, Tine , BERGHOLD KUHLMANN, Reidun
CPC分类号： G06T7/0016 , C12M21/06 , C12M41/46 , G06F3/00 , G06K9/4671 , G06K9/6215 , G06K9/66 , G06T7/246 , G06T11/60 , G06T2207/10016 , G06T2207/30044
摘要： Apparatus and methods for helping a user establish values (e.g. timings) for a plurality of parameters of interest (e.g. cell divisions) relating to the development of an embryo from a series of images of the embryo are described. For each parameter of interest an image is selected for display to a user seeking to establish a value for the parameter of interest. For example, the selected image may be an image predicted to be an image reflecting the value for the parameter of interest. For example, the selected image may be based on a calculated timing for a particular developmental event. The timing may be calculated from a numerical analysis of the images or maybe predetermined. If the user is unable to determine a value for the parameter of interest from the selected image, the user may scroll through neighbouring images until the user can determine a value for the parameter of interest. A value for the proud of interest may then be established in response to user input, for example a user providing an indication that a timing associated with a currently displayed image from the series of images should be taken to be the value of the parameter of interest. The different parameters of interest may be established in an iterative manner in which an initial image for display to a user is selected for each parameter of interest based on the parameter of interest.
摘要翻译： 描述了用于帮助用户为与胚胎的一系列图像相关的胚胎发育相关的多个感兴趣参数（例如细胞分裂）建立值（例如定时）的装置和方法。 对于感兴趣的每个参数，选择图像以显示给寻求为感兴趣的参数建立值的用户。 例如，所选择的图像可以是预测为反映感兴趣参数的值的图像的图像。 例如，所选择的图像可以基于针对特定发展事件的计算的定时。 时间可以根据图像的数值分析或者可以预先确定。 如果用户不能从所选择的图像确定感兴趣的参数的值，则用户可以滚动遍历相邻图像，直到用户可以确定感兴趣的参数的值。 然后可以响应于用户输入建立感兴趣的值的值，例如用户提供指示与来自该系列图像的当前显示的图像相关联的定时应该被认为是感兴趣的参数的值的指示 。 感兴趣的不同参数可以以迭代方式建立，其中基于感兴趣的参数为用户显示的初始图像被选择用于感兴趣的每个参数。
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公开(公告)号：EP1949297B1
公开(公告)日：2015-07-29
申请号：EP06791469.7
申请日：2006-10-16
CPC分类号： C12M21/06 , C12M41/46 , C12M41/48 , G06K9/00127 , G06T7/0016 , G06T7/254 , G06T2200/24 , G06T2207/30004
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